Abstract
Drug allergies which result in urticaria, angioedema, circulatory insufficiency, or shock are characterized by the fact that some individuals exhibit abnormal reactions without warning, often after the drug has been in widespread clinical use. The reaction can be mediated through an antigen-antibody reaction or through an anaphylactoid reaction probably without involving antibodies in some cases. Certain histamine liberators also produce erythema, pruritus and oedema, symptoms which closely resemble the allergic forms of urticaria and angioedema. Other drugs form complexes with proteins and these then may act as antigens stimulating the host to produce antibodies. However, the reactivity of the host may also be related to its genetical background. For example, the ability of mice to form antibodies to certain polypeptides is controlled by a dominant factor as not all mice are able to respond to these compounds, yet all the mice make antibodies to polypeptides of slightly higher molecular weight [1]. Furthermore, guinea-pigs can be bred selectively to show differences in susceptibility of their skin to dinitrochloro-benzene and to hapten-polylysine conjugates [2].
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© 1970 Birkhäuser Verlag Basel
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West, G.B., Starr, M.S. (1970). A new Approach to the Medical Interpretation of Shock. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques, vol 14. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7075-7_4
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DOI: https://doi.org/10.1007/978-3-0348-7075-7_4
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