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Abstract

Since the first review on cholesterol and its relation to atherosclerosis was written for this series a decade ago by Lin and Chen [1], great strides have been made in the field. Although the role of lipids and cholesterol in atherosclerosis has not been fully clarified to the satisfaction of the clinician, medicinal chemistry has been quite successful during this interval in showing that a diverse group of compounds is capable of reducing blood lipid levels in many animal species and in man. It is of special interest to scan through the galenical compositions as outlined by Lin and Chen, and to compare these with the well-characterized synthetic hypolipidemic agents which have emerged since that time.

Keywords

Nicotinic Acid Serum Cholesterol Level Cholesterol Biosynthesis Mevalonic Acid Hypolipidemic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1]
    Tsung-Min Lin and K. K. Chen, Progress in Drug Research, vol. 1, p. 127 (Ed. E. Jucker; Birkhäuser, Basel 1959).Google Scholar
  2. [2]
    R. Hess, Advances in Lipid Research, vol. 2, p. 296 (Eds. R. Paoletti and D. Kritchevsky; Academic Press, New York 1964).Google Scholar
  3. [3]
    F. Marchand, Verhandl. 21 Kongr. Inn. Med. 23 (1904).Google Scholar
  4. [4]
    G. Pickering, Am. J. Med. 34, 7 (1963).Google Scholar
  5. [5]
    T. R. Dawber and W. B. Kannel, Am. J. Public Health 53, 433 (1963).Google Scholar
  6. [6]
    B. Biörck, J. Atherosclerosis Res. 5, 261 (1965).Google Scholar
  7. [7]
    J. J. Ghidoni and R. M. O’Neal, Exptl. Mol. Pathol. 7, 378 (1967)Google Scholar
  8. [8]
    R. Hess and W. Stäubli, Atherosclerosis, p. 49–71 (Eds. G. Schettler and G. S. Boyd; Elsevier, Amsterdam 1969).Google Scholar
  9. [9]
    C. J. F. Böttcher, Proc. Roy. Soc. Med. 57, 792 (1964).Google Scholar
  10. [10]
    R. W. Wissler, J. Atherosclerosis Res. 8, 201 (1968).Google Scholar
  11. [11]
    W. Insull, Jr. and G. E. Bartsch, J. Clin. Invest. 45, 513 (1966).Google Scholar
  12. [12]
    R. F. Scott, R. A. Florentin, A. S. Daoud, E. S. Morrison, R. M. Jones, and M. S. R. Hutt, Exptl. Mol. Pathol. 5, 12 (1966).Google Scholar
  13. [13]
    A. V. Chobanian and W. J. Hollander, J. Clin. Invest.41, 1732(1962).Google Scholar
  14. [14]
    C. J. F. Böttcher and C. M. van Gent, J. Atherosclerosis Res. 1, 36 (1961).Google Scholar
  15. [15]
    V. C. Y. Kao and R. W. Wissler, Exptl. Mol. Pathol. 4, 465 (1965).Google Scholar
  16. [16]
    W. Hollander, Exptl. Mol. Pathol. 7, 248 (1967).Google Scholar
  17. [17]
    From the Prescription Industry Fact Book, Table 32 (Published by the Pharmaceutical Manufacturers Association, Washington, D. C., 1968).Google Scholar
  18. [18]
    Medical Research. A Midcentury Review, vol. 2, p. 193 (Ed. E. E. Lape; Little, Brown and Co., Boston, Mass., 1955).Google Scholar
  19. [19]
    S. Oldham, Mfg. Chemists, 39, 30 (1968).Google Scholar
  20. [20]
    W. B. Kannel, T. R. Dawber, G. D. Friedman, W. E. Glennon, and P. M. McNamara, Ann. Internal Med. 61, 888 (1964).Google Scholar
  21. [21]
    W. B. Kannel, T. R. Dawber, and P. M. McNamara, J. Iowa Med. Soc. 56, 26 (1966).Google Scholar
  22. [22]
    T. R. Dawber and W. B. Kannel, Circulation 34, 553 (1966).Google Scholar
  23. [23]
    L. K. Widmer and G. Hartman, Soziosomatik der Kreislaufkrankheiten, p. 126 (Eds. R. Thauer and C. Albers; Steinhopff, Darmstadt 1966).Google Scholar
  24. [24]
    A. Kagan, T. R. Dawber, W. B. Kannel, and N. Revotskie, Federation Proc. 21, Suppl. No. 11, 52(1962).Google Scholar
  25. [25]
    M. J. Albrink, Arch. Internal Med. 109, 345 (1962).Google Scholar
  26. [26]
    L. A. Carlson, Acta Med. Scand. 167, 399 (1960).Google Scholar
  27. [27]
    B. Hood, S. Björk, R. Sannerstedt, and G. Angervall, Acta Med. Scand. 174, 393 (1963).Google Scholar
  28. [28]
    P. D. White, Rheumatic and Coronary Heart Disease, p. 139 (Eds. C. P. Bailey, S. Gollub, and G. A. Shapiro; J. B. Lippincott Co., Philadelphia 1967).Google Scholar
  29. [29]
    Final Report of the National Diet-Heart-Study Group, Circulation 37, No. 3, Suppl. 1 (1968).Google Scholar
  30. [30]
    P. Leren, Acta Med. Scand. Suppl. 466 (1966).Google Scholar
  31. [31]
    J. W. Gofman, W. Young, and R. Tandy, Circulation 34, 679 (1966).Google Scholar
  32. [32]
    M. F. Oliver and C. H. Stuart-Harris, Brit. Med. J. II. 1203 (1965).Google Scholar
  33. [33]
    G. Christakis, S. H. Rinzler, M. Archer, G. Winslow, S. Jampel, J. Stephenson, G. Friedman, H. Fein, A. Kraus, and G. James, Am. J. Public Health 56, 299 (1966).Google Scholar
  34. [34]
    M. F. Oliver, Modern Trends in Pharmacology and Therapeutics, p. 221 (Ed. W. F. M. Fulton; Butterworths, London 1967).Google Scholar
  35. [35]
    G. Hartmann, unpublished results, ‘Basel Study’ (1968).Google Scholar
  36. [36]
    D. S. Fredrickson, R. I. Levy, and R. S. Lees, New Engl. J. Med. 276, 34, 94, 148, 215, 273 (1968).Google Scholar
  37. [37]
    P. T. Kuo and D. R. Bassett, J. Am. Med. Assoc. 201, 87 (1967).Google Scholar
  38. [38]
    M. J. Albrink, J. W. Meigs, and E. B. Man, Am. J. Med. 31, 4 (1961).Google Scholar
  39. [39]
    I. McDonald and I. Obeyesekere, J. Atherosclerosis Res. 7, 530 (1967).Google Scholar
  40. [40]
    R. Hellstroem, Acta Med. Scand. 182, 727 (1967).Google Scholar
  41. [41]
    M. F. Oliver, V. A. Kurien, and T. W. Greenwood, Lancet I. 710 (1968).Google Scholar
  42. [42]
    Editorial, J. Am. Med. Assoc. 200, No. 12, 37 (1967).Google Scholar
  43. [43]
    J. Stamler, Progress in Biochemical Pharmacology, vol. 4, p. 626 (Eds. C. J. Miras, A. N. Howard, and R. Paoletti; S. Karger, Basel 1968).Google Scholar
  44. [44]
    R. Altschul, A. Hoffer, and J. D. Stephen, Arch, Biochem. Biophys. 54, 558 (1955).Google Scholar
  45. [45]
    W. B. Parsons, Jr., R. W. P. Archor, K. G. Berge, B. F. McKenzie, and N. W. Barker, Proc. Staff Meetings Mayo Clinic 31, 377 (1956).Google Scholar
  46. [46]
    L. A. Carlson and L. Oroe, Acta Med. Scand. 172, 641 (1962).Google Scholar
  47. [47]
    N. A. Christensen, R. W. P. Achor, K. Berge, and H. L. Mason, Diseases Chest 46, 411 (1964).Google Scholar
  48. [48]
    M. Mahl and K. Lange, Am. J. Med. Sci. 246, 673 (1963).Google Scholar
  49. [49]
    W. B. Parsons, Jr., Arch. Internal Med. 107, 653 (1961).Google Scholar
  50. [50]
    T. A. Miettinen, Clin. Chim. Acta 20, 43 (1968).Google Scholar
  51. [51]
    M. Verstraete, H. Maes, and J. Vermylen, Med. Pharmacol. Exptl. 13, 401 (1965).Google Scholar
  52. [52]
    N. Padolecchia, A. Panaro, V. Fasano, and L. Armenio, Giorn. Clin. Med. 44, 1015 (1963);Google Scholar
  53. [52a]
    N. Padolecchia, A. Panaro, V. Fasano, and L. Armenio, Chem. Abs. 63, 3522d (1965).Google Scholar
  54. [53]
    L. A. Carlson, C. Hebdom, E. Helgstrand, B. Sjoeberg, and N. E. Stjernstroem, Abstracts of 3rd International Symposium on Drugs Affecting Lipid Metabolism, p. 35 (Milan 1968).Google Scholar
  55. [54]
    G. Ratti and E. deFina, Lancet II, 917 (1959).Google Scholar
  56. [55]
    L. Bizzi and E. Grossi, Arzneimittel-Forschg. 11, 265 (1961).Google Scholar
  57. [56]
    P. Preziosi, B. Loscalzo, E. Marmo, and E. Miele, Arch. Ital. Sci. Farmacol. 11, 386 (1961);Google Scholar
  58. [56a]
    P. Preziosi, B. Loscalzo, E. Marmo, and E. Miele, Chem. Abs. 61, 7536b (1964).Google Scholar
  59. [57]
    A. Kappert, Curr. Ref. Med. Lit. (Winthrop), No. 1142, 6 (Nov. 6) (1961).Google Scholar
  60. [58]
    S. H. Lumish, C. Blyn, and J. H. Nodine, Current Therap. Res. Clin. Exptl. 4, 243 (1962).Google Scholar
  61. [59]
    S. O. Brattgard, R. Brattsand, and J. G. Harthorn, Arzneimittel-Forschg. 16, 145 (1966).Google Scholar
  62. [60]
    G. Dell’Omodarme and F. Brunori, Boll. Chim. Farm. 100, 732 (1961).Google Scholar
  63. [61]
    G. R. Locatelli, Gazz. Med. Ital. 125, 37 (1966);Google Scholar
  64. [61a]
    G. R. Locatelli, Chem. Abs. 65 4507d (1966).Google Scholar
  65. [62]
    C. P. Krimmel, U. S. Pat. 3,321,484 (1967);Google Scholar
  66. [62a]
    C. P. Krimmel, Chem. Abs. 68, 21,840t (1968).Google Scholar
  67. [63]
    Jap. Pat. 17,023(65′); Chem. Abs. 63, 18038d (1965).Google Scholar
  68. [64]
    J. Nordmann and H. Swierkot, U.S. Pat. 3,367,939 (1968);Google Scholar
  69. [64a]
    J. Nordmann and H. Swierkot, Chem. Abs. 65, 13,667a (1966).Google Scholar
  70. [65]
    H. Schoen, W. Zeller, and N. Henning, Klin. Wochschr. 41, 1108 (1963).Google Scholar
  71. [66]
    S. Heyden-Stucky, Schweiz. Med. Wochschr. 97, 451 (1967).Google Scholar
  72. [67]
    N. Zoellner and M. Gudenzi, Med. Klin. (Munich) 61, 1996, 2036 (1966).Google Scholar
  73. [68]
    K. F. Gey, Progress in Biochemical Pharmacology, vol. 4, p. 626 (Eds. C. J. Miras, A. N. Howard, and R. Paoletti; S. Karger, Basel 1968).Google Scholar
  74. [69]
    W. A. Bolhofer, U. S. Pat. 3,369,025 (1968);Google Scholar
  75. [69]
    W. A. Bolhofer, Chem. Abs. 68, 39, 487t (1968).Google Scholar
  76. [70]
    G. F. Holland and J. N. Pereira, J. Med. Chem. 10, 149 (1967).Google Scholar
  77. [71]
    J. M. McManus and R. M. Herbst, J. Org. Chem. 24, 1464 (1959).Google Scholar
  78. [72]
    J. M. Thorp, J. Atherosclerosis Res. 3, 351 (1963).Google Scholar
  79. [73]
    S. K. Figdor and M. Schach von Wittenau, J. Med. Chem. 10, 1158 (1967).Google Scholar
  80. [74]
    J. N. Pereira, Abstracts of the 3rd International Symposium on Drugs Affecting Lipid Metabolism, p. 61 (Milan 1968).Google Scholar
  81. [75]
    A. Bizzi, A. Jori, E. Veneroni, and S. Garattini, Life. Sci. 3, 1371 (1964).Google Scholar
  82. [76]
    W. E. Dulin, G. H. Lund, and G. Gerritsen, Proc. Soc. Exptl. Biol. Med. 118, 499 (1965).Google Scholar
  83. [77]
    D. L. Smith, A. A. Forist, and W. E. Dulin, J. Med. Chem. 8, 350 (1965).Google Scholar
  84. [78]
    G. Tamasi, J. Borsy, and A. Patthy, Med. Pharmacol. Exptl. 16, 573 (1967).Google Scholar
  85. [79]
    E. R. Froesch, M. Waldvogel, U. A. Meyer, A. Jakob, and A. Labhart, Mol. Pharmacol. 3, 429, 442 (1967).Google Scholar
  86. [80]
    W. E. Dulin and G. Gerritsen, Proc. Soc. Exptl. Biol. Med. 121, 777 (1966).Google Scholar
  87. [81]
    J. N. Pereira and G. F. Holland, J. Pharmacol. Exptl. Therap. 157, 381 (1967).Google Scholar
  88. [82]
    A. Bizzi, A. M. Codegoni, and S. Garattini, Farmaco (Pavia) Ed. Sci. 22, 709 (1967).Google Scholar
  89. [83]
    L. A. Carlson, Ann. N. Y. Acad. Sci. 131, 119 (1965).Google Scholar
  90. [84]
    S. Bergstroem, L. Krabisch, and J. Sjoevall, Acta Chem. Scand. 14, 1706 (1960).Google Scholar
  91. [85]
    P. W. Ramwell, J. E. Shaw, G. B. Clarke, M. F. Grostic, D. G. Kaiser, and J. E. Pike, Progress in the Chemistry of Fats and Other Lipids, vol. 9, p. 73 (Ed. R. Holman; Pergamon Press, Oxford 1967).Google Scholar
  92. [86]
    S. H. Ferreira and J. R. Van, Nature 216, 873 (1967).Google Scholar
  93. [87]
    S. Bergstroem, L. A. Carlson, and L. Oroe, Acta Physiol. Scand. 67, 185 (1966).Google Scholar
  94. [88]
    S. Bergstroem, L. A. Carlson, and J. R. Weeks, Pharmacol. Rev. 20, 1 (1968).Google Scholar
  95. [89]
    A. Bizzi, A. M. Codegoni, and S. Garattini, Nature 204, 1205 (1964).Google Scholar
  96. [90]
    T. Brody, Pharmacol. Rev. 18, 253 (1966).Google Scholar
  97. [91]
    M. Friedman and S. O. Byers, Am. J. Physiol. 213, 829 (1967).Google Scholar
  98. [92]
    S. Garattini and A. Bizzi, Pharmacol. Rev. 18, 243 (1966).Google Scholar
  99. [93]
    R. H. Furman, P. Alaupovic, R. H. Bradford, and R. P. Howard, Progress in Biochemical Pharmacology, vol. 4, p. 334 (Eds. C. J. Miras, A. N. Howard, and R. Paoletti; S. Karger, Basel 1968).Google Scholar
  100. [94]
    R. H. Furman, P. Alaupovic, and R. P. Howard, Progress in Biochemical Pharmacology, vol. 2, p. 215 (Eds. D. Kritchevsky, R. Paoletti, and D. Steinberg; S. Karger, Basel 1967).Google Scholar
  101. [95]
    J. Stamler, L. N. Katz, R. Pick, L. A. Lewis, I. H. Page, A. Pick, B. M. Kaplan, D. M. Berkson, and D. Century, Proceedings of the Symposium on Drugs Affecting Lipid Metabolism, p. 432 (Eds. S. Garattini and R. Paoletti; Elsevier Publishing Co., Amsterdam 1961).Google Scholar
  102. [96]
    J. Marmorston, F. J. Moore, C. E. Hopkins, O. T. Kuzma, and J. Weiner, Proc. Soc. Exptl. Biol. 110, 400 (1962).Google Scholar
  103. [97]
    H. S. Kroman, S. R. Bender, A. N. Brest, and M. L. Moskovitz, J. Atherosclerosis Res. 6, 247 (1966).Google Scholar
  104. [98]
    J. J. Fisher, Obstet. Gynecol. Survey 9, 479 (1954).Google Scholar
  105. [99]
    I. Lorenzen0 and V. Headings, Acta Endocrinol. 53, 619 (1966).Google Scholar
  106. [100]
    A. H. Goldkamp, W. M. Hoehn, R. A. Mikulec, E. F. Nutting, and D. L. Cook, J. Med. Chem. 8, 409 (1965).Google Scholar
  107. [101]
    L. J. Chinn, J. Med. Chem. 9, 602 (1966).Google Scholar
  108. [102]
    Z. Cekan, K. Syhora, J. Jelinek, and M. Seda, J. Eur. Steroides 1, 135 (1966).Google Scholar
  109. [103]
    G. C. Buzby, Jr., D. Hartley, G. A. Hughes, H. Smith, B. W. Gadsby, and A. B. A. Jansen, J. Med. Chem. 10, 199 (1967).Google Scholar
  110. [104]
    M. R. Malinow, A. L. Gimeno, A. A. Pellegrino-Iraldi, M. A. Fernandez-Gimeno, G. E. Bur, J. L. Lacuara, and J. A. Moguilevsky, J. Endocrinol. 21, 1 (1960).Google Scholar
  111. [105]
    D. D. Evans, D. E. Evans, G. S. Lewis, P. J. Palmer, and D. J. Weyell, J. Pharm. Pharmacol. 16, 717 (1964).Google Scholar
  112. [106]
    G. M. K. Hughes, P. F. Moore, and R. B. Stebbins, J. Med. Chem. 7, 511 (1964).Google Scholar
  113. [107]
    French Pat. M. 1594 (1963); Chem. Abs. 59, 718b (1963).Google Scholar
  114. [108]
    D. F. Morrow and R. M. Hofer, J. Med. Chem. 9, 249 (1966).Google Scholar
  115. [109]
    E. W. Cantrall, S. Bernstein, and W. Cekleniak, Belg. Pat. 634,712 (1965);Google Scholar
  116. [109a]
    E. W. Cantrall, S. Bernstein, and W. Cekleniak, Chem. Abs. 62, 1522c (1965).Google Scholar
  117. [110]
    S. Kraychy, J. Am. Chem. Soc. 81, 1702 (1959).Google Scholar
  118. [111]
    J. Fishman, M. Tomasz, and R. Lehman, J. Org. Chem. 25, 585 (1960).Google Scholar
  119. [112]
    B. Pelc, Collection Czech. Chem. Commun. 32, 3953 (1967).Google Scholar
  120. [113]
    A. Arnold, G. O. Potts, J. P. McAuliff, R. G. Christiansen, and T. C. Miller, Proc. Soc. Exptl. Biol. Med. 121, 122 (1966).Google Scholar
  121. [114]
    A. Arnold, J. P. McAuliff, and A. J. Merola, J. Atherosclerosis Res. 7, 111 (1967).Google Scholar
  122. [115]
    G. C. Buzby, Jr., E. Capaldi, G. H. Douglas, D. Hartley, D. Herbst, G. A. Hughes, K. Ledig, J. McMenamin, T. Pattison, H. Smith, C. R. Walks, G. R. Wendt, J. Sidall, B. Gadsby, and A. B. A. Jansen, J. Med. Chem. 9, 338 (1966).Google Scholar
  123. [116]
    J. F. Poletto, G. R. Allen, Jr., and M. J. Weiss, J. Med. Chem. 10, 106 (1967).Google Scholar
  124. [117]
    A. U. Rivin, Metab. Clin. Exptl 8, 704 (1959).Google Scholar
  125. [118]
    C. H. Robinson, N. F. Bruce, E. P. Oliveto, S. Tolksdorf, M. Steinberg, and P. L. Perlman, J. Am. Chem. Soc. 82, 5256 (1960).Google Scholar
  126. [119]
    J. S. Baran, J. Med. Chem. 10, 1039 (1967).Google Scholar
  127. [120]
    G. C. Buzby, Jr., R. A. Edgren, J. A. Fisher, G. A. Hughes, R. C. Jones, K. Ledig, T. W. Pattison, R. Rees, H. Smith, L. L. Smith, D. M. Teller, and G. R. Wendt, J. Med. Chem. 7, 755 (1964).Google Scholar
  128. [121]
    P. de Ruggieri, C. Gandolfi, and D. Chiaramonti, Gazz. Chim. Ital. 93, 269 (1963).Google Scholar
  129. [122]
    C. H. Robinson, N. F. Bruce, and E. P. Oliveto, J. Med. Chem. 6, 793 (1963).Google Scholar
  130. [123]
    R. E. Schaub, J. H. van der Hende, and M. J. Weiss, J. Org. Chem. 30, 2234 (1965).Google Scholar
  131. [124]
    H. Smith, G. H. Douglas, and C. R. Walk, Experientia 20, 418 (1964).Google Scholar
  132. [125]
    P. Loustalot, W. Schuler, and W. Albrecht, Proceedings of the Symposium on Drugs Affecting Lipid Metabolism, p. 271 (Eds. S. Garattini and R. Paoletti; Elsevier Publishing Company, Amsterdam 1961).Google Scholar
  133. [126]
    J. L. Lowe, D. A. Peak, and T. I. Watkins, J. Chem. Soc. 3286 (1951).Google Scholar
  134. [127]
    P. Balatre and J. F. Merlen, Therapie 15, 83 (1960);Google Scholar
  135. [127]
    P. Balatre and J. F. Merlen, Chem. Abs. 57, 7868c (1962).Google Scholar
  136. [128]
    E. A. Brown and L. J. Chinn, U. S. Pat. 3,139,430 (1964);Google Scholar
  137. [128a]
    E. A. Brown and L. J. Chinn, Chem Abs. 63, 8287a (1965).Google Scholar
  138. [129]
    W. A. Bolhofer and J. M. Sprague, U. S. Pat. 3,139,430 (1964);Google Scholar
  139. [129a]
    W. A. Bolhofer and J. M. Sprague, Chem. Abs. 61, 11948a (1964).Google Scholar
  140. [130]
    G. W. Moersch, D. F. Morrow, and W. A. Neukxis, J. Med. Chem. 10, 154 (1967).Google Scholar
  141. [131]
    T. R. Blohm, L. J. Lerner, T. Kariya, and M. E. Winje, Circulation Res. 6, 260 (1958);Google Scholar
  142. [131a]
    T. R. Blohm, L. J. Lerner, T. Kariya, and M. E. Winje, Chem. Abs. 52, 13037i (1958).Google Scholar
  143. [132]
    R. Harris, Am. J. Cardiol. 4, 274 (1959).Google Scholar
  144. [133]
    F. P. Paopoli, R. E. Allen, E. L. Schumann, W. C. Day, and M. G. van Campen, p. 12–0 (134th Meeting Am. Chem. Soc. 1958).Google Scholar
  145. [134]
    F. P. Palopoli, Progr. Cardiovascular Diseases 2, 489 (1960).Google Scholar
  146. [135]
    J. Avigan, D. Steinberg, H. E. Vroman, M. J. Thompson, and E. Mosettig, J. Biol. Chem. 235, 3123 (1960).Google Scholar
  147. [136]
    D. Steinberg, J. Avigan, and E. B. Feigelson, Progr. Cardiovascular Diseases 2, 586 (1960).Google Scholar
  148. [137]
    J. H. Herndon, Jr. and M. D. Siperstein, Circulation Res. 12, 228 (1963).Google Scholar
  149. [138]
    C. Roux and R. Dupuis, Compt. Rend. Soc. Biol. 155, 2255 (1961).Google Scholar
  150. [139]
    B. C. Wexler, Endocrinology 74, 64 (1964).Google Scholar
  151. [140]
    A. Scanu, W. A. Hawk, and I. H. Page, Arch. Pathol. 73, 445 (1962).Google Scholar
  152. [141]
    R. W. P. Achor, R. K. Winkelmann, and H. O. Perry, Proc. Staff Meetings Mayo Clinic 36, 217 (1961).Google Scholar
  153. [142]
    R. C. Laughlin and T. F. Carey, J. Am. Med. Assoc. 181, 339 (1962).Google Scholar
  154. [143]
    W. L. Bencze and M. J. Allen, J. Med. Pharm. Chem. 1, 395 (1959).Google Scholar
  155. [144]
    W. L. Bencze, U. S. Pat. 3,007,934 (1962);Google Scholar
  156. [144]
    W. L. Bencze, Chem. Abs. 56, 4736h (1962).Google Scholar
  157. [145]
    W. L. Bencze, Brit. Pat. 899,057 (1963);Google Scholar
  158. [145]
    W. L. Bencze, Chem. Abs. 58, 10180a (1963).Google Scholar
  159. [146]
    H. A. deWald, O. D. Bird, G. Rodney, D. H. Kaump, and M. L. Black, Nature 221, 538 (1966).Google Scholar
  160. [147]
    F. P. Palopoli and V. J. Feil, U. S. Pat. 3,247,252 (1966);Google Scholar
  161. [147]
    F. P. Palopoli and V. J. Feil, Chem. Abs. 65, 3790a (1966).Google Scholar
  162. [148]
    J. R. Boissier, R. Ratouis, C. Dumont, J. Lesbros, and J. P. Lavaux, Arzneimittel-Forschg. 17, 1193 (1967).Google Scholar
  163. [149]
    Brit. Pat. 966,696 (1964); Chem. Abs. 61,11976e (1964).Google Scholar
  164. [150]
    W. L. Bencze, U. S. Pat. 3,250,767 (1966);Google Scholar
  165. [150a]
    W. L. Bencze, Chem. Abs. 65, 7102h (1966).Google Scholar
  166. [151]
    H. B. Wright, D. A. Dunnigan, and U. Biermacher, J. Med. Chem. 7, 113 (1964).Google Scholar
  167. [152]
    J. H. Burckhalter, W. D. Dixon, M. L. Black, R. D. Westland, L. M. Werbel, H. A. deWald, J. R. Dice, G. Rodney, and D. H. Kaump, J. Med. Chem. 10, 565 (1967).Google Scholar
  168. [153]
    I. Schumacher, Diss. Abs. 23, 3138 (1963).Google Scholar
  169. [154]
    H. B. Wright and D. L. Martin, J. Med. Chem. 11, 390 (1968).Google Scholar
  170. [155]
    J. L. Schmidt and D. L. Martin, Toxicol. Appl. Pharmacol. 7, 257 (1965).Google Scholar
  171. [156]
    J. H. Short, U. Biermacher, D. A. Dunnigan, G. F. Lambert, D. L. Martin, C. W. Nordeen, and H. B. Wright, J. Med. Chem. 8, 223 (1965).Google Scholar
  172. [157]
    C. L. Zirkle, U. S. Pat. 3,097,206 (1963);Google Scholar
  173. [157]
    C. L. Zirkle, Chem. Abs. 59, 13950f (1963).Google Scholar
  174. [158]
    J. P. English, F. L. Bach, Jr., and S. Gordan, U. S. Pat. 3,330,832 (1967);Google Scholar
  175. [158]
    J. P. English, F. L. Bach, Jr., and S. Gordan, Chem. Abs. 68, 49453t (1968).Google Scholar
  176. [159]
    F. L. Bach, J. C. Barclay, and E. Cohen, J. Med. 10, 802 (1967).Google Scholar
  177. [160]
    F. L. Bach, J. C. Barclay, F. Kende, and E. Cohen, J. Med. Chem. 11, 987 (1968).Google Scholar
  178. [161]
    S. Gordon and W. P. Cekleniak, J. Med. Chem. 11, 993 (1968).Google Scholar
  179. [162]
    E. N. Morgan, P. J. Palmer, L. Kruszynska, and W. R. N. Williamson, J. Chem. Soc. 3887 (1965).Google Scholar
  180. [163]
    K. J. Rorig, U. S. Pat. 3,123,615 (1964);Google Scholar
  181. [163]
    K. J. Rorig, Chem. Abs. 61, 3119f (1964).Google Scholar
  182. [164]
    I. H. Page and R. E. Schneckloth, Circulation 20, 1075 (1959).Google Scholar
  183. [165]
    R. H. Furman, R. P. Howard, L. N. Norcia, and C. W. Robinson, Jr., Proc. Soc. Exptl. Biol. Med. 103, 302 (1960).Google Scholar
  184. [166]
    E. M. Schultz, W. A. Bolhofer, A. Augenblick, J. B. Bicking, C. N. Habecker, J.K. Horner, S.F. Kwong, and A.M. Pietruszkiewicz, J. Med. Chem. 10, 717 (1967).Google Scholar
  185. [167]
    S. H. Pines, J. M. Chemerda, M. A. Kozlowski, L. M. Weinstock, P. Davis, B. Hendelsman, V. J. Grenda, and G. W. Lindberg, J. Med. Chem. 10, 725 (1967).Google Scholar
  186. [168]
    M. Perelman and S. Mizsak, J. Med. Chem. 6, 533 (1963).Google Scholar
  187. [169]
    W. L. Bencze, unpublished results.Google Scholar
  188. [170]
    W. A. Philips and P. E. Schurr, Federation Proc. 26, 653, abs. 2222 (1967).Google Scholar
  189. [171]
    W. L. Bencze, L. I. Barsky, R. W. J. Carney, A. A. Renzi, and G. de Stevens, J. Med. Chem. 10, 138 (1967).Google Scholar
  190. [172]
    G. W. Duncan, S. C. Lyster, J. J. Clark, and D. Lednicer, Proc. Soc. Exptl. Biol. Med. 112, 439 (1963).Google Scholar
  191. [173]
    T. A. Miettinen, J. Lab. Clin. Med. 71, 537 (1968).Google Scholar
  192. [174]
    D. G. McDevitt, R. G. Shanks, D. R. Hadden, D. A. D. Montgomery, and J. A. Weaver, Lancet I, 998 (1968)Google Scholar
  193. [175]
    L. Vanhaelst, P. Neve, P. Chailly, and P. A. Bastenie, Lancet II, 800 (1967).Google Scholar
  194. [176]
    E. T. Borrows, J. C. Clayton, and B. A. Hems, J. Chem. Soc. 199 (1949).Google Scholar
  195. [177]
    J. R. Chalmers, G. T. Dickson, J. Elks, and B. A. Hems, J. Chem. Soc. 3424 (1949).Google Scholar
  196. [178]
    R. I. Meltzer and R. J. Stanabeck, J. Org. Chem. 26, 1977 (1961).Google Scholar
  197. [179]
    H. A. Selenkow and M. S. Wool, Topics in Medical Chemistry, vol. 1, p. 241 (Eds. J. L. Rabinovitz and R. M. Myerson; Interscience, New York 1967).Google Scholar
  198. [180]
    D. Kritchevsky and S. A. Tepper, J. Atherosclerosis Res. 7, 103 (1967).Google Scholar
  199. [181]
    Flint Laboratories, Clin. Pharmacol. Ther. 8, 629 (1967).Google Scholar
  200. [182]
    P. Starr, P. Roen, J. L. Freibrun, and L. A. Schleissner, Arch. Internal Med. 105, 830 (1960).Google Scholar
  201. [183]
    Editorial, J. Amer. Med. Assoc. 199, 578 (1967).Google Scholar
  202. [184]
    B. M. Cohen, Current Therap. Res. Clin. Exptl. 9, 618 (1967).Google Scholar
  203. [185]
    R. L. Searcy, D. A. Hungerford, and E. M. Y. Low, Current Therap. Res. Clin. Exptl. 10, 177 (1968).Google Scholar
  204. [186]
    J. L. Rabinovitz, T. Rodman, and R. M. Myerson, J. Amer. Med. Assoc. 183, 758 (1963).Google Scholar
  205. [187]
    W. B. Parsons, Jr., Mayo Clinic Proc. 40, 822 (1965).Google Scholar
  206. [188]
    S. B. Barker, Ann. Rev. Physiol. 17, 417 (1955).Google Scholar
  207. [189]
    F. J. Kessler, H. L. Krueskemper, and G. Noell, Arzneimittel-Forschg. 17, 1190 (1967).Google Scholar
  208. [190]
    C. M. Greenberg, C. A. Bocher, J. F. Kerwin, S. M. Greenberg, and T. H. Lin, Am. J. Physiol. 201, 732 (1961).Google Scholar
  209. [191]
    B. Blank, F. R. Pfeiffer, C. M. Greenberg, and J. F. Kerwin, J. Med. Chem. 6, 554 (1963).Google Scholar
  210. [192]
    B. Blank, F. R. Pfeiffer, C. M. Greenberg, and J. F. Kerwin, J. Med. Chem. 6, 560 (1963).Google Scholar
  211. [193]
    B. Blank, C. M. Greenberg, and J. F. Kerwin, J. Med. Chem. 7, 53 (1964).Google Scholar
  212. [194]
    E. C. Jorgensen, C. M. Greenberg, N. Zenker, and P. A. Lehman, Proc. Intern. Pharmacol. Meeting 1st, Stockholm 1961 (2) 123, (Pub. 1962);Google Scholar
  213. [194a]
    E. C. Jorgensen, C. M. Greenberg, N. Zenker, and P. A. Lehman, Chem. Abs. 61, 13599h (1964).Google Scholar
  214. [195]
    E. C. Jorgensen and P. A. Lehman, J. Org. Chem. 26, 897 (1961).Google Scholar
  215. [196]
    B. Blank, F. R. Pfeiffer, and C. M. Greenberg, J. Med. Chem. 9, 832 (1966).Google Scholar
  216. [197]
    W. J. Wechter, W. A. Phillips, and F. Kagan, J. Med. Chem. 8,474 (1965).Google Scholar
  217. [198]
    A. Baender and H. Nahm, Arzneimittel-Forsch. 13, 1 (1963).Google Scholar
  218. [199]
    J. H. Oppenheimer, G. Bernstein, and J. Hasen, J. Clin. Invest. 46, 762 (1967).Google Scholar
  219. [200]
    J. H. Oppenheimer, New Engl. J. Med. 278, 1153 (1968).Google Scholar
  220. [201]
    C. S. Hollander, R. L. Scott, J. A. Burgess, D. Rabinowitz, T. T. Merimee, and J. H. Oppenheimer, J. Clin. Endocrinol. Metab. 27, 1219 (1967).Google Scholar
  221. [202]
    J. N. Fisher and E. G. Ball, Biochemistry 6, 637 (1967).Google Scholar
  222. [203]
    F. A. Gries, F. Matschinsky, and O. Wieland, Biochem. Biophys. Acta. 56, 615 (1962).Google Scholar
  223. [204]
    S. C. Werner and J. A. Naumann, Ann. Rev. Physiol. 30, 213 (1968).Google Scholar
  224. [205]
    A. I. Pastac, Compt. Rend. 256, 318 (1963);Google Scholar
  225. [205a]
    A. I. Pastac, Chem. Abs. 58, 9535c (1963).Google Scholar
  226. [206]
    J. Redel and J. Cottet, Compt. Rend. 236, 2553 (1953);Google Scholar
  227. [206a]
    J. Redel and J. Cottet, Chem. Abs. 48, 13061h (1954).Google Scholar
  228. [207]
    J. Redel, J. Salesse, and J. P. Martinaud, Bull. Soc. Chim. Biol. 37, 1189 (1955);Google Scholar
  229. [207a]
    J. Redel, J. Salesse, and J. P. Martinaud, Chem. Abs. 50, 8889e (1956).Google Scholar
  230. [208]
    J. Redel, J. Cottel, J. Salesse, and M. E. Tricaud, Compt. Rend. 243, 926 (1956);Google Scholar
  231. [208a]
    J. Redel, J. Cottel, J. Salesse, and M. E. Tricaud, Chem. Abs. 52, 15733f (1958).Google Scholar
  232. [209]
    S. Garattini, C. Morpurgo, B. Murelli, R. Paoletti, and N. Passerini, Arch. Intern. Pharmacodyn. 109, 400 (1957).Google Scholar
  233. [210]
    D. Steinberg and D. S. Fredrickson, Proc. Soc. Exptl. Biol. Med. 90, 232 (1955).Google Scholar
  234. [211]
    D. Steinberg and D. S. Fredrickson, Ann. N. Y. Acad. Sci. 64, 579 (1956).Google Scholar
  235. [212]
    J. Cottet, A. Mathivat, and J. Redel, Press Med. 62, 939 (1954).Google Scholar
  236. [213]
    D. S. Fredrickson and D. Steinberg, Circulation 15, 391 (1957).Google Scholar
  237. [214]
    F. Grande, J. T. Anderson, and A. Keys, Metab. Clin. Exptl. 6, 154 (1957).Google Scholar
  238. [215]
    G. Weitzel, E. Buddecke, and H. Koenig, Z. Physiol. Chem. 310, 139 (1958);Google Scholar
  239. [215a]
    G. Weitzel, E. Buddecke, and H. Koenig, Chem. Abs. 52, 13118h (1958).Google Scholar
  240. [216]
    L. Canonica, A. Bonati, and C. Tedeschi, Farmaco (Pavia) Ed. Sci. 13, 286 (1958).Google Scholar
  241. [217]
    A. M. Naser, Kardiologiya 52 (1964);Google Scholar
  242. [217a]
    A. M. Naser, Chem. Abs. 63, 3522h (1965).Google Scholar
  243. [218]
    I. B. Simon, Farmakol. Ser. Sosud. Veshchestv. Sb. 183 (1965);Google Scholar
  244. [218a]
    I. B. Simon, Chem. Abs. 65, 19175b (1966).Google Scholar
  245. [219]
    Lab. Dausse A. S. and Société B. M. C., Fr. Pat. 1,397,116 (1965);Google Scholar
  246. [219a]
    Lab. Dausse A. S. and Société B. M. C., Chem. Abs. 63, 8271a (1965).Google Scholar
  247. [220]
    R. Delaby, P. Reynaud, and F. Lilly, Bull. Soc. Chim. France 2067 (1961).Google Scholar
  248. [221]
    D. Bargeton, M. E. Tricaud-Redel, and A. Rouques, Arch. Intern. Pharmacodyn. 136, 63 (1962);Google Scholar
  249. [221a]
    D. Bargeton, M. E. Tricaud-Redel, and A. Rouques, Chem. Abs. 57, 3974g (1962).Google Scholar
  250. [222]
    P. Vulliemoz, F. Aquet, G. Favez, F. Gattlen, and J. M. Matthieu, Schweiz. Med. Wochschr. 95, 1051 (1965).Google Scholar
  251. [223]
    E. Stueber and H. G. Wolf, Wien. Med. Wochschr. 115, 49 (1965).Google Scholar
  252. [224]
    Madan A. G., Belg. Pat. 648, 892 (1965);Google Scholar
  253. [224a]
    Madan A. G., Chem. Abs. 63, 13148f (1965).Google Scholar
  254. [225]
    V. Scarselli and A. Fossati, Farmaco (Pavia) Ed. Sci. 16, 23 (1961).Google Scholar
  255. [226]
    C. Canonica, A. Bonati, L. Gaudenzi, and G. Motta, Farmaco (Pavia) Ed. Sci. 14, 112 (1959).Google Scholar
  256. [227]
    V. Scarselli and E. Servida, Farmaco (Pavia) Ed. Prat. 16, 311 (1961).Google Scholar
  257. [228]
    F. Sanguinetti and M. L. Zannoni, Minerva Med. 54, 2925 (1963);Google Scholar
  258. [228a]
    F. Sanguinetti and M. L. Zannoni, Chem. Abs. 60, 7340h (1964).Google Scholar
  259. [229]
    L. Canonica, P. Manitto, U. Valcavi, and N. Zonta, Bolego, J. Biol. Chem. 243, 1645 (1968).Google Scholar
  260. [230]
    P. Samuel, C. M. Holtzman, and O. B. Shalchi, Circulation, 27, 1138 (1963).Google Scholar
  261. [231]
    D. G. Gallo, A. L. Sheffner, and H. P. Sarett, Federation Proc. 22, 269 abs. 647 (1963).Google Scholar
  262. [232]
    R. H. Wiley and H. C. van der Plas, J. Chem. Eng. Data 10, 72 (1965);Google Scholar
  263. [232a]
    R. H. Wiley and H. C. van der Plas, Chem. Abs. 62, 11728e (1965).Google Scholar
  264. [233]
    Merck and Co., Brit. Pat. 838,569 (1960); Chem. Abs. 55, 2575g (1961).Google Scholar
  265. [234]
    F. F. Blicke and N. Grier, J. Am. Chem. Soc. 65, 1725 (1943).Google Scholar
  266. [235]
    P. A. Tavormina and M. Gibbs, J. Am. Chem. Soc. 79, 758 (1957).Google Scholar
  267. [236]
    S. Garattini, C. Morpugo, and N. Passerini, Giorn. Ital. Chemioterap. 2, 60 (1955);Google Scholar
  268. [236a]
    S. Garattini, C. Morpugo, and N. Passerini, Chem. Abs. 50,15661i (1956).Google Scholar
  269. [237]
    S. Garattini, C. Morpugo, and N. Passerini, Experientia 12, 347 (1956).Google Scholar
  270. [238]
    I. Taddei and F. Bianchi-Bandinelli, Arch. Ital. Sci, Farmacol. Ser. 3, 11, 270 (1961);Google Scholar
  271. [238a]
    I. Taddei and F. Bianchi-Bandinelli, Chem. Abs. 57, 6548i (1962).Google Scholar
  272. [239]
    G. Annoni, Farmaco (Pavia) Ed. Sci. 11, 244 (1956);Google Scholar
  273. [239a]
    G. Annoni, Chem. Abs. 50, 10271e (1956).Google Scholar
  274. [240]
    G. M. Kauchtschischwili, Arch. Studio Fisiopatol. Clin. Ricambio 24, 350 (1960);Google Scholar
  275. [240a]
    G. M. Kauchtschischwili, Chem. Abs. 59, 6880b (1963).Google Scholar
  276. [241]
    S. Garattini, C. Morpugo, P. Paoletti, and R. Paoletti, Arzneimittel-Forschg. 9, 206 (1959).Google Scholar
  277. [242]
    A. Kellner, J. W. Carrell, and A. T. Ladd, J. Exptl. Med. 93, 373 (1951).Google Scholar
  278. [243]
    M. Friedman and S. O. Byers, J. Exptl. Med. 97, 117 (1953).Google Scholar
  279. [244]
    G. Cavallini, E. Massarani, D. Nardi, and R. J. d’Ambrosio, J. Am. Chem. Soc. 79, 3514 (1957).Google Scholar
  280. [245]
    G. Cavallini, E. Massarani, D. Nardi, L. Mauri, F. Barzaghi, and P. Mantegazza, J. Am. Chem. Soc. 81, 2564 (1959).Google Scholar
  281. [246]
    E. Testori, Gazz. Intern. Med. Chir. 63, 2447 (1959).Google Scholar
  282. [247]
    E. Sabbadini and M. Gazzaniga, Minerva Med. 1543 (1959);Google Scholar
  283. [247a]
    E. Sabbadini and M. Gazzaniga, Chem. Abs. 53, 20503d (1959).Google Scholar
  284. [248]
    T. Wagner-Jauregg and H. Saner, Arzneimittel-Forschg. 9, 579 (1959).Google Scholar
  285. [249]
    P. Morand, J. F. Bagli, M. Kraml, and J. Dubuc, J. Med. Chem. 7, 504 (1964).Google Scholar
  286. [250]
    C. H. Eades, Jr., C. M. Weiss, V. B. Solberg, and G. E. Phillips, Med. Pharmacol. Exptl. 14, 225 (1966).Google Scholar
  287. [251]
    C. H. Eades, Jr. and V. B. Solberg, Med. Pharmacol. Exptl. 14, 234 (1966).Google Scholar
  288. [252]
    C. H. Eades, Jr. and V. B. Solberg, Med. Pharmacol. Exptl. 14, 241 (1966).Google Scholar
  289. [253]
    S. Casadio, G. Pala, T. Bruzzese, and E. Marazzi-Uberti, Farmaco (Pavia) Ed. Sci. 17, 797 (1962).Google Scholar
  290. [254]
    S. Casadio, G. Pala, T. Bruzzese, and E. Marazzi-Uberti, Farmaco (Pavia) Ed. Sci. 17, 810 (1962).Google Scholar
  291. [255]
    G. Coppi and G. Bonardi, Biochim. Biol. Sper. 3, 272 (1964);Google Scholar
  292. [255a]
    G. Coppi and G. Bonardi, Chem. Abs. 62, 16819c (1965).Google Scholar
  293. [256]
    E. Crescenzi and E. Marazzi-Uberti, Farmaco (Pavia) Ed. Sci. 19, 929 (1964);Google Scholar
  294. [256a]
    E. Crescenzi and E. Marazzi-Uberti, Chem. Abs. 62, 5238f (1965).Google Scholar
  295. [257]
    E. Szarvasi and L. Neuvy, Bull. Soc. Chim. France 1343 (1962).Google Scholar
  296. [258]
    E. Szarvasi, Fr. Pat. 1,342,159 (1963);Google Scholar
  297. [258a]
    E. Szarvasi, Chem. Abs. 60, 6827f (1964).Google Scholar
  298. [259]
    E. Szarvasi, Fr. Addn. 83,531 (1964 to Fr. 1,342,159);Google Scholar
  299. [259a]
    E. Szarvasi, Chem. Abs. 62, 535a (1965).Google Scholar
  300. [260]
    S. L. Shapiro, H. Soloway, H. Shapiro, and L. Freedman, J. Pharm. Sci. 50, 973 (1961).Google Scholar
  301. [261]
    S. L. Shapiro, L. Freedman, and H. Soloway, U. S. Pat. 3,081,302 (1963);Google Scholar
  302. [261a]
    S. L. Shapiro, L. Freedman, and H. Soloway, Chem. Abs. 59, 6318h (1963).Google Scholar
  303. [262]
    S. L. Shapiro, T. Bazga, and L. Freedman, J. Pharm. Sci. 51, 582 (1962).Google Scholar
  304. [263]
    E. Magnien, F. Testa, and S. L. Shapiro, J. Med. Chem. 9, 449 (1966).Google Scholar
  305. [264]
    G. Cavallini, E. Massarani, D. Nardi, and L. Mauri, Farmaco (Pavia) Ed. Sci. 18, 595 (1963).Google Scholar
  306. [265]
    G. Cavallini and E. Massarani, U. S. Pat. 3,169,144 (1965);Google Scholar
  307. [265a]
    G. Cavallini and E. Massarani, Chem. Abs. 62, 11738e (1965).Google Scholar
  308. [266]
    M. M. Melandri and P. Galimberti, Chim. Ther. 2, 9 (1967).Google Scholar
  309. [267]
    P. Galimberti and V. Gerosa, Farmaco (Pavia) Ed. Sci. 9, 160 (1954).Google Scholar
  310. [268]
    P. Galimberti and A. Defranceschi, Gazz. Chim. Ital. 77, 431 (1947);Google Scholar
  311. [268a]
    P. Galimberti and A. Defranceschi, Chem. Abs. 42, 3361i (1948).Google Scholar
  312. [269]
    M. Julia, M. Baillarge, and G. Tchernoff, Bull. Soc. Chim. France 776 (1956).Google Scholar
  313. [270]
    J. M. Thorp and W. S. Waring, Nature 194, 948 (1962).Google Scholar
  314. [271]
    W. Blynne, M. Jones, J. M. Thorp, and W. S. Waring, Brit. Pat. 860,303 (1961);Google Scholar
  315. [271a]
    W. Blynne, M. Jones, J. M. Thorp, and W. S. Waring, Chem. Abs. 55, 24680b (1961).Google Scholar
  316. [272]
    J. M. Thorp, Lancet 1,1323 (1962).Google Scholar
  317. [273]
    L. Hellman, B. Zumoff, G. Kessler, E. Kara, I. L. Rubin, and R. S. Rosenfeld, Ann. Internal Med. 59, 477 (1963).Google Scholar
  318. [274]
    J. H. Butterfield, J. Atherosclerosis Res. 3, 747 (1965).Google Scholar
  319. [275]
    Editorial, Circulation 36, 337 (1967).Google Scholar
  320. [276]
    G. G. Duncan, F. A. Elliott, T. G. Duncan, and J. Schatanoff, Metabl. Clin. Exptl. 17, 457 (1968).Google Scholar
  321. [277]
    B. A. Sachs, Am. Heart J. 75, 707 (1968).Google Scholar
  322. [278]
    Merck and Co., Neth. Appl. 6,500,136 (1965); Chem. Abs. 64, 3422g (1966).Google Scholar
  323. [279]
    Merck and Co., Neth. Appl. 6,607,056 (1966); Chem. Abs. 67, 73351h (1967).Google Scholar
  324. [280]
    Merck and Co., Neth. Appl. 6,506,442 (1965); Chem. Abs. 65, 651f (1966).Google Scholar
  325. [281]
    C. Ainsworth, D. N. Benslay, J. Davenport, J. L. Hudson, D. Kau, T. M. Lin, and R. R. Pfeiffer, J. Med. Chem. 10, 158 (1967).Google Scholar
  326. [282]
    R. L. Buchanan and R. A. Partyka, U. S. Pat. 3,337,576 (1967);Google Scholar
  327. [282a]
    R. L. Buchanan and R. A. Partyka, Chem. Abs. 68, 114608p (1968).Google Scholar
  328. [283]
    Merck and Co., Neth. Appl. 6,515,769 (1966); Chem. Abs. 65, 15296a (1966).Google Scholar
  329. [284]
    T. Leigh, D. S. Platt, and J. M. Thorp, Abstracts 3rd International Symposium on Drugs Affecting Lipid Metabolism, p. 138 (Milan 1968).Google Scholar
  330. [285]
    R. Hess and W. L. Bencze, Experientia 24, 418 (1968).Google Scholar
  331. [286]
    G. Hartmann and G. Forster, Abstracts 3rd International Symposium on Drugs Affecting Lipid Metabolism, p. 126 (Milan 1968).Google Scholar
  332. [287]
    M. Eggstein, M. Hollmann, and W. Knodel, Abstracts 3rd International Symposium on Drugs Affecting Lipid Metabolism, p. 109 (Milan 1968).Google Scholar
  333. [288]
    D. Nardi, L. Mauri, and F. Barzaghi, Farmaco (Pavia) Ed. Sci. 20, 456 (1965).Google Scholar
  334. [289]
    W. A. Phillips, and P. E. Schurr, Federation Proc. 27, 439 abs. 1249 (1968).Google Scholar
  335. [290]
    A. R. Timms, R. G. Griot, and J. A. Spirito, Federation Proc. 27, 242 (1968).Google Scholar
  336. [291]
    L. A. Kelly and R. S. Ho, Federation Proc. 27, 242 abs. 147 (1968).Google Scholar
  337. [292]
    D. Berkowitz, E. deFelice, and P. Arcese, Abstracts 3rd International Symposium on Drugs Affecting Lipid Metabolism, p. 89 (Milan 1968).Google Scholar
  338. [293]
    A. Burger, D. G. Markees, W. R. Nex, and W. L. Yost, J. Am. Chem. Soc. 71, 3307 (1949).Google Scholar
  339. [294]
    Merck and Co., Neth. Appl. 6,503,523 (1965); Chem. Abs. 64, 5003a (1966).Google Scholar
  340. [295]
    H. Rudney and J. J. Ferguson, Jr., J. Am. Chem. Soc. 79, 5580 (1957).Google Scholar
  341. [296]
    H. Rudney, CIBA Foundation Symposium on the Biosynthesis of Terpenes and Sterols, p. 75 (Eds. G. E. W. Wolstenholme and M. O’Connor; J. and A. Churchill Ltd., London 1959).Google Scholar
  342. [297]
    K. Bloch, Science 150, 19 (1965).Google Scholar
  343. [298]
    R. K. Maudgal, T. T. Tchen, and K. Bloch, J. Am. Chem. Soc. 80, 2589 (1959).Google Scholar
  344. [299]
    J. W. Cornforth, R. H. Cornforth, A. Pelter, M. G. Horning, and G. Popjak, Tetrahedron 5, 311 (1959).Google Scholar
  345. [300]
    D. L. Azarnoff, D. R. Tucker, and G. A. Barr, Metab. Clin. Expl. 14, 959 (1965).Google Scholar
  346. [301]
    S. W. Teal and W. Gamble, Biochem. Pharmacol. 14, 896 (1965).Google Scholar
  347. [302]
    K. Folkers, C. H. Shunk, B. O. Linn, F. M. Robinson, P. E. Wittreich, J. W. Huff, J. L. Gilfillan, and H. R. Skeggs, CIBA Foundation Symposium on the Biosynthesis of Terpenes and Sterols, p. 20 (Eds. G. E. W. Wolstenholme and O’Connor; J. and A. Churchill Ltd., London 1959).Google Scholar
  348. [303]
    A. F. Novak and S. M. Hauge, J. Biol. Chem. 174, 647 (1948).Google Scholar
  349. [304]
    M. D. Siperstein and V. M. Fagan, Federation Proc. 21, 300 (1962).Google Scholar
  350. [305]
    J. M. Stewart and D. W. Woolley, J. Am. Chem. Soc. 81, 4951 (1959).Google Scholar
  351. [306]
    E. D. Bergman and S. Cohen, Tetrahedron Letters No. 8, 20 (1960).Google Scholar
  352. [307]
    R. Tschesche, H. Machleidt, and T. Bucher, U. S. Pat. 3,075,997 (1963);Google Scholar
  353. [307a]
    R. Tschesche, H. Machleidt, and T. Bucher, Chem. Abs. 59, 1492h (1963).Google Scholar
  354. [308]
    F. M. Singer, J. P. Januszka, and A. Borman, Proc. Soc. Exptl. Biol. Med. 102, 370 (1959).Google Scholar
  355. [309]
    Roussel-UCLAF, Fr. Pat. M1700 (1963);Google Scholar
  356. [309a]
    Roussel-UCLAF, Chem. Abs. 59, 9907d (1963).Google Scholar
  357. [310]
    L. Canonica, L. Gaudenzi, G. Jommi, and U. Valcavi, Gazz. Chim. Ital. 91, 1400 (1961);Google Scholar
  358. [310a]
    L. Canonica, L. Gaudenzi, G. Jommi, and U. Valcavi, Chem. Abs. 56, 15416f (1962).Google Scholar
  359. [311]
    K. Taratori and K. Imai, Jap. Pat. 734 (’66) (1964);Google Scholar
  360. [311a]
    K. Taratori and K. Imai, Chem. Abs. 64, 11315c (1966).Google Scholar
  361. [312]
    H. U. Daeniker and J. Druey, Helv. Chim. Acta 43, 983 (1960).Google Scholar
  362. [313]
    R. G. Westall, Biochem. J. 55, 244 (1953).Google Scholar
  363. [314]
    S. Trippett, J. Chem. Soc. 1957 (1929).Google Scholar
  364. [315]
    H. Eggerer, Ann. Chem. 657, 212 (1962).Google Scholar
  365. [316]
    A. Schoeberl, J. Borchers, and D. Hantzsch, Chem. Ber. 101, 373 (1968).Google Scholar
  366. [317]
    Z. H. Beg and M. Siddiqi, Experientia 23, 380 (1967).Google Scholar
  367. [318]
    Z. H. Beg, M. Siddiqi, and R. A. H. Siddiqi, Experientia 24, 15 (1968).Google Scholar
  368. [319]
    G. Palazzo, M. Tavella, and G. Strani, J. Med. Pharm. Chem. 4, 447 (1961).Google Scholar
  369. [320]
    H. Weiss, E. Schiffmann, and E. Titus, J. Lipid Res. 2, 258 (1961).Google Scholar
  370. [321]
    C. Mentzer, G. Zwingelstein, and J. Jouanneteau, Compt. Rend. 242, 943 (1956).Google Scholar
  371. [322]
    M. Perrault, G. Zwingelstein, J. Jouanneteau, and C. Mentzer, Pathol. et biol. Semaine hop. 7, 411 (1959);Google Scholar
  372. [322a]
    M. Perrault, G. Zwingelstein, J. Jouanneteau, and C. Mentzer, Chem. Abs. 55, 6706g (1961).Google Scholar
  373. [323]
    J. Supniewski, A. Dluzniewski, S. Czekaj, and J. Vetulani, Bull. Acad, Polon. Sci., Ser. Sci. Biol. 8, 237 (1960);Google Scholar
  374. [323a]
    J. Supniewski, A. Dluzniewski, S. Czekaj, and J. Vetulani, Chem. Abs. 55, 2885f (1961).Google Scholar
  375. [324]
    P. Coirre, Fr. Pat. M2922 (1964);Google Scholar
  376. [324a]
    P. Coirre, Chem. Abs. 62, 10344a (1965).Google Scholar
  377. [325]
    S. L. Shapiro and L. Freedman, U. S. Pat. 3,193,458 (1965);Google Scholar
  378. [325a]
    S. L. Shapiro and L. Freedman, Chem. Abs. 63, 12980e (1965).Google Scholar
  379. [326]
    H. Machleidt, U. S. Pat. 3,210,377 (1965);Google Scholar
  380. [326a]
    H. Machleidt, Chem. Abs. 65, 2131c (1966).Google Scholar
  381. [327]
    W. A. Bolhofer, U. S. Pat. 3,027,406 (1962);Google Scholar
  382. [327a]
    W. A. Bolhofer, Chem. Abs. 56, 14410h (1962).Google Scholar
  383. [328]
    R. Tschesche, H. Machleidt, and V. Hartmann, U. S. Pat. 3,193,565 (1965);Google Scholar
  384. [328a]
    R. Tschesche, H. Machleidt, and V. Hartmann, Chem. Abs. 63, 9990f (1965).Google Scholar
  385. [329]
    L. D. Wright and M. Cleland, Proc. Soc. Exptl. Biol. Med. 96, 219 (1957).Google Scholar
  386. [330]
    H. R. Levy and G. Popjak, Biochem. J. 75, 417 (1960).Google Scholar
  387. [331]
    Merck and Co., Brit. Pat. 838,568 (1960); Chem. Abs. 55, 2575f (1961).Google Scholar
  388. [332]
    Merck and Co., Brit. Pat. 838,747 (1960); Chem. Abs. 55, 4364h (1961).Google Scholar
  389. [333]
    G. Popjak, R. H. Cornforth, and K. Clifford, Lancet I, 1270 (1960).Google Scholar
  390. [334]
    J. Jouanneteau and G. Zwingelstein, Compt. Rend. 252, 1380 (1961).Google Scholar
  391. [335]
    W. A. Bolhofer, U. S. Pat. 2,928,854 (1960);Google Scholar
  392. [335a]
    W. A. Bolhofer, Chem. Abs. 54, 14130f (1960).Google Scholar
  393. [336]
    W. A. Bolhofer, U. S. Pat. 3,031,481 (1962);Google Scholar
  394. [336a]
    W. A. Bolhofer, Chem. Abs. 57, 9668c (1962).Google Scholar
  395. [337]
    L. G. Humber, M. Kraml, J. Dubuc, and R. Gaudry, J. Med. Chem. 6, 210 (1963).Google Scholar
  396. [338]
    M. Kraml, L. G. Humber, J. Dubuc, and R. Gaudry, J. Med. Chem. 7, 500 (1964).Google Scholar
  397. [339]
    L. G. Humber, G. S. Myers, and T. Massiah, U. S. Pat. 3,202,709 (1965);Google Scholar
  398. [339a]
    L. G. Humber, G. S. Myers, and T. Massiah, Chem. Abs. 63, 13147f (1965).Google Scholar
  399. [340]
    L. G. Humber, J. Med. Chem. 7, 826 (1964).Google Scholar
  400. [341]
    L. H. Humber, C. I. Chappel, A. V. Marton, M. Kraml, and J. Dubuc, J. Med. Chem. 9, 329 (1966).Google Scholar
  401. [342]
    D. Dvornik, M. Kraml, and J. F. Bagli, J. Am. Chem. Soc. 86, 2739 (1964).Google Scholar
  402. [343]
    D. Dvornik, M. Kraml, J. Dubuc, M. Givner, and R. Gaudry, J. Am. Chem. Soc. 55, 3309 (1963).Google Scholar
  403. [344]
    A. V. Marton, E. Greselin, M. Givner, and K. Voith, Endorcrinology 75, 469 (1964).Google Scholar
  404. [345]
    P. Hill and E. Greselin, Toxicol. Appl. Pharmacol. 11, 245 (1967).Google Scholar
  405. [346]
    P. Hill and J. G. Rochefort, Can. J. Biochem. 44, 1239 (1966).Google Scholar
  406. [347]
    R. Niemiro and R. Fumagalli, Biochim. Biophys. Acta 98, 624 (1965).Google Scholar
  407. [348]
    R. Rodney, M. L. Black, and O. D. Bird, Biochem. Pharmacol. 14, 445 (1965).Google Scholar
  408. [349]
    P. N. Craig, I. H. Witt, E. Macko, J. G. Dacanay, E. J. Fellows, and G. E. Ullyot, J. Am. Chem. Soc. 73, 1339 (1951).Google Scholar
  409. [350]
    E. J. Fellows, U. S. Pat. 2,807,566 (1957);Google Scholar
  410. [350a]
    E. J. Fellows, Chem. Abs. 52, 1560b (1958).Google Scholar
  411. [351]
    J. R. Gillette, Progress in Drug Research, vol. 6, p. 11 (Ed. E. Jucker; Birkhäuser, Basel 1963).Google Scholar
  412. [352]
    E. C. Dick, S. M. Greenberg, J. F. Herndon, M. Jones, and E. J. van Loon, Proc. Soc. Exptl. Biol. Med. 104, 523 (1960).Google Scholar
  413. [353]
    B. M. Sutton, U. S. Pat. 3,174,994 (1965);Google Scholar
  414. [353a]
    B. M. Sutton, Chem. Abs. 62, 16143c (1965).Google Scholar
  415. [354]
    W. L. Holmes and J. D. Bentz, J. Biol. Chem. 235, 3118 (1960).Google Scholar
  416. [355]
    W. L. Holmes and N. W. DiTullio, Am. J. Clin. Nutr. 10, 310 (1962).Google Scholar
  417. [356]
    W. L. Holmes, Lipid Pharmacology, p. 153 (Ed. R. Paoletti; Acadamic Press, New York 1964).Google Scholar
  418. [357]
    M. W. Whitehouse, P. D. G. Dean, and P. R. Raggatt, Progress in Biochemical Pharmacology, vol. 2, p. 30 (Ed. R. Paoletti; S. Karger; Basel 1967).Google Scholar
  419. [358]
    K. J. Netter, J. Jenner, and K. Kajuschke, Naunyn-Schmiedebergs Arch. Pharmakol. Path. Exp. 259, 1 (1967).Google Scholar
  420. [359]
    M. M. Best and C. H. Duncan, J. Lab. Clin. Med. 64, 634 (1964).Google Scholar
  421. [360]
    D. L. Azarnoff, D. R. Tucker, and G. A. Barr, Metab. Clin. Exptl. 14, 959 (1965).Google Scholar
  422. [361]
    D. R. Avoy, E. A. Swyryd, and R. G. Gould, J. Lipid Res. 6, 369 (1965).Google Scholar
  423. [362]
    R. Hess, W. Stäubli, and W. Riess, Nature 208, 856 (1965).Google Scholar
  424. [363]
    D. S. Platt and B. L. Cockrill, Biochem. Pharmacol. 15, 927 (1966).Google Scholar
  425. [364]
    D. S. Platt and B. L. Cockrill, Biochem. Pharmacol. 16, 2257 (1967).Google Scholar
  426. [365]
    W. L. Bencze, U. S. Pat. 3,332,842 (1967);Google Scholar
  427. [365a]
    W. L. Bencze, Brit. Pat. 1,002,667;Google Scholar
  428. [365b]
    W. L. Bencze, Chem. Abs. 62, 16142h (1965).Google Scholar
  429. [366]
    D. J. Svoboda, H. Grady, and D. L. Azarnoff, J. Cell. Biol. 35, 127 (1967).Google Scholar
  430. [367]
    M. D. Siperstein and M. J. Guest, J. Clin. Invest. 39, 642 (1960).Google Scholar
  431. [368]
    E. P. Madhava Bhattathiry and M. D. Siperstein, J. Clin. Invest. 42, 1613 (1963).Google Scholar
  432. [369]
    C. B. Davis, Jr., G. E. Cox, C. B. Taylor, and S. L. Cross, Surg. Forum 9, 486 (1959).Google Scholar
  433. [370]
    C. B. Taylor and Kang-Jey Ho, Arch. Pathol. 84, 3 (1967).Google Scholar
  434. [371]
    R. Hess, Advances in Lipid Research, vol. 2, p. 343 (Eds. R. Paoletti and D. Kritchevsky; Academic Press, New York 1964).Google Scholar
  435. [372]
    Y. Aramaki, T. Kobayashi, Y. Imai, S. Kikuchi, T. Matsukawa, and K. Kanazawa, J. Atherosclerosis Res. 7, 653 (1967).Google Scholar
  436. [373]
    E. W. Cantrall, R. Littell, S. M. Stolar, W. P. Cekleniak, H. J. Albers, S. Gordon, and S. Bernstein, Steroids 7, 173 (1963).Google Scholar
  437. [374]
    W. A. Phillips and J. Avigan, Proc. Soc. Exptl. Biol. Med. 112, 233 (1963).Google Scholar
  438. [375]
    M. Alauddin and M. Martin-Smith, J. Pharm. Pharmacol. 14, 325 (1962).Google Scholar
  439. [376]
    M. Martin-Smith and M. F. Sugrue, J. Pharm. Pharmacol. 16, 569 (1964).Google Scholar
  440. [377]
    W. L. Holmes, J. Amer. Oil. Chem. Soc. 41, 702 (1964).Google Scholar
  441. [378]
    W. L. Holmes and N. W. DiTullio, Progress in Biochemical Pharmacology, vol. 2, p. 1 (Eds. D. Kritchevsky, R. Paoletti, and D. Steinberg; S. Karger, New York 1967).Google Scholar
  442. [379]
    N. J. Doorenbos and M. T. Wu, J. Pharm. Sci. 54, 1290 (1965).Google Scholar
  443. [380]
    D. M. Dvornik and M. J. Kraml, Circulation 36, Suppl. II, 9 (1967).Google Scholar
  444. [381]
    R. E. Counsell, P. D. Klimstra, L. N. Nysted, and R. E. Ranney, J. Med. Chem. 5, 45 (1965).Google Scholar
  445. [382]
    R. E. Ranney and E. G. Daskalakis, Proc. Soc. Exptl. Biol. Med. 116, 999 (1964).Google Scholar
  446. [383]
    R. E. Ranney, D. L. Cook, W. E. Hambourger, and R. E. Counsell, J. Pharmacol. Exptl. Therap. 142, 132 (1963).Google Scholar
  447. [384]
    R. E. Ranney, Progress in Biochemical Pharmacology, vol. 2, p. 50 (Eds. D. Kritchevsky, R. Paoletti, and D. Steinberg; S. Karger, New York 1967).Google Scholar
  448. [385]
    N. Winer, J. M. Martt, J. E. Somers, L. Wolcott, H. E. Dale, and J. W. Burns, J. Lab. Clin. Med. 66, 758 (1965).Google Scholar
  449. [386]
    N. Winer, D. M. Klachko, R. D. Baer, P. L. Langley, and T. W. Burns, Science 153, 312 (1966).Google Scholar
  450. [387]
    P. D. Klimstra, R. E. Ranney, and R. E. Counsell, J. Med. Chem. 9, 323 (1966).Google Scholar
  451. [388]
    A. D. Cross, E. Denot, R. Acevedo, and P. Crabbe, Steroide 5, 585 (1965).Google Scholar
  452. [389]
    T. F. Gallagher, L. Hellman, H. L. Bradlow, B. Zumoff, and D. K. Fukushima, Ann. N. Y. Acad. Sci. 86, 605 (1960).Google Scholar
  453. [390]
    L. Hellman, H. L. Bradlow, B. Zumoff, D. K. Fukushima, and T. F. Gallagher, J. Clin. Endocrinol. Metab. 19, 936 (1959).Google Scholar
  454. [391]
    N. T. Werthessen, Circulation 16, 484 (1957).Google Scholar
  455. [392]
    R. H. Furman, R. P. Howard, L. N. Norcia, and E. C. Keaty, Am. J. Med. 24, 80 (1958).Google Scholar
  456. [393]
    H. Schoen and H. Zeller, Münch. Med. Wochschr. 104, 2433 (1962).Google Scholar
  457. [394]
    V. Felt, J. Clin. Endocrinol. Metab. 26, 683 (1966).Google Scholar
  458. [395]
    J. F. Dingman and N. Y. Lim, J. Am. Med. Assoc. 186, 316 (1963).Google Scholar
  459. [396]
    R. Gaunt, B. G. Steinetz, and J. J. Chart, Clin. Pharmacol. Therap. 9, 657 (1968).Google Scholar
  460. [397]
    Editorial, Nutr. Rev. 26, 8 (1968).Google Scholar
  461. [398]
    M. Kirschner and M. Lipsett, Acta Endocrinal. 46, 207 (1964).Google Scholar
  462. [399]
    M. Ben-David, S. Dikstein, G. Bismuth, and F. G. Sulman, Proc. Soc. Exptl. Biol. Med. 125, 1136(1967).Google Scholar
  463. [400]
    B. A. Sachs and L. Wolfman, Metab. Clin. Exptl. 17, 400 (1968).Google Scholar
  464. [401]
    P. A. Desaulles, Ch. Krähenbühl, W. Schüler, and H. J. Bein, Schweiz. Med. Wochschr. 89, 1313 (1959).Google Scholar
  465. [402]
    M. Verdy, L. Tetreault, W. Murphy, and L. Perron, Canad. Med. Assoc. J. 98, 397 (1968).Google Scholar
  466. [403]
    R. P. Howard and R. H. Furman, J. Clin. Endocrinol. Metab. 22, 43 (1962).Google Scholar
  467. [404]
    K. Nakamura, A. Toyota, Y. Masuda, and H. Nakamura, J. Atherosclerosis Res. 7, 783 (1967).Google Scholar
  468. [405]
    I. Chevillard, C. Bournique, H. Kagan, and R. Portet, Therapie 20, 371 (1965);Google Scholar
  469. [405a]
    I. Chevillard, C. Bournique, H. Kagan, and R. Portet, Chem. Abs. 63, 3374f (1965).Google Scholar
  470. [406]
    L. L. Abell and E. H. Mosbach, J. Lipid Res. 9, 98 (1968).Google Scholar
  471. [407]
    R. E. Counsell and P. D. Klimstra, J. Med. Chem. 7, 119 (1964).Google Scholar
  472. [408]
    R. E. Ranney and F. J. Saunders, Proc. Soc. Exptl. Biol. Med. 116, 596 (1964).Google Scholar
  473. [409]
    R. E. Ranney and S. H. Grayson, Arch. Int. Pharmacodyn. Ther. 158, 265 (1965).Google Scholar
  474. [410]
    G. Fiegel and D. Kukwa, Arzneimittel-Forschg. 18, 452 (1968).Google Scholar
  475. [411]
    F. M. Berger, J. F. Douglas, B. J. Ludwig, and S. Margolin, Proc. Soc. Exptl. Med. 714, 337 (1963).Google Scholar
  476. [412]
    J. F. Douglas, Proc. Soc. Exptl. Biol. Med. 117, 190 (1964).Google Scholar
  477. [413]
    J. F. Douglas, B. J. Ludwig, S. Margolin, and F. M. Berger, J. Atherosclerosis Res. 6, 90 (1966).Google Scholar
  478. [414]
    D. Kritchevsky and S. A. Tepper, Proc. Soc. Exptl. Biol. Med. 121, 1162 (1966).Google Scholar
  479. [415]
    J. F. Douglas, J. Pharmacol. Exptl. Therap. 150, 105 (1965).Google Scholar
  480. [416]
    J. Edelson, A. Schlosser, and J. F. Douglas, Biochem. Pharmacol. 17, 779 (1968).Google Scholar
  481. [417]
    B. J. Ludwig, F. Duersch, M. Auerbach, K. Tomeczek, and F. M. Berger, J. Med. Chem. 10, 556 (1967).Google Scholar
  482. [418]
    F. M. Berger, B. J. Ludwig, J. F. Douglas, and S. Margolin, Abstracts 3rd International Symposium on Drugs Affecting Lipid Metabolism, p. 88 (Milan 1968).Google Scholar
  483. [419]
    A. O. Ilvespää and A. Marxer, Chimia (Aarau) 18, 1 (1964).Google Scholar
  484. [420]
    P. Mamalis, L. Jeffries, S. A. Price, M. J. Rix, and D. J. Outred, J. Med. Chem. 8, 684 (1965).Google Scholar
  485. [421]
    T. Shimamoto, Asian Med. J. 3, 479 (1960).Google Scholar
  486. [422]
    B. M. Bloom, R. E. Carnahan, R. P. Rowe, J. B. Thomson, and R. Zager, Abstracts of papers 135th Am. Chem. Soc. Meeting, p. 24N (Boston, April 1959).Google Scholar
  487. [423]
    T. Shimamoto, F. Numano, and T. Fujita, Am. Heart J. 71, 216 (1966).Google Scholar
  488. [424]
    T. Shimamoto, H. Maezawa, H. Yamazaki, T. Atsumi, T. Fujita, T. Ishioka, and T. Sunaga, Am. Heart J. 71, 297 (1966).Google Scholar
  489. [425]
    M. R. Malinow, A. Perley, and P. A. MacLaughlin, Circulation 36, Suppl. II, 25 (1967).Google Scholar
  490. [426]
    D. Kritchevsky and S. A. Tepper, Experientia 23, 1006 (1967).Google Scholar
  491. [427]
    T. Shimamoto, Am. Heart J. 76, 105 (1968).Google Scholar
  492. [428]
    T. Shimamoto, T. Atsumi, F. Numano, and T. Fujita, Progress in Biochemical Pharmacology, vol. 4, p. 597 (Eds. C. J. Miras, A. N. Howard, and R. Paoletti; S. Karger, New York 1968).Google Scholar
  493. [429]
    L. W. Kinsell, J. Partridge, L. Boling, S. Margen, and G. Michaels, J. Clin. Endocrinol. Metab. 12, 909 (1952).Google Scholar
  494. [430]
    J. Groen, B. K. Tjiong, C. E. Kamminga, and A. F. Willebrands, Voeding 13, 556 (1952);Google Scholar
  495. [430a]
    J. Groen, B. K. Tjiong, C. E. Kamminga, and A. F. Willebrands, Chem. Abs. 47, 4973g (1953).Google Scholar
  496. [431]
    R. Hess, Advances in Lipid Research, vol. 2, p. 401 (Eds. R. Paoletti and D. Kritchevsky; Academic Press, New York 1964).Google Scholar
  497. [432]
    H. Nakatani, H. Fukushima, A. Wakimura, and M. Endo, Science 153, 1267 (1966).Google Scholar
  498. [433]
    D. Kritchevsky and S. A. Tepper, J. Atherosclerosis Res. 7, 527 (1967).Google Scholar
  499. [434]
    D. Kritchevsky, P. Sallata, and S. A. Tepper, Proc. Soc. Exptl. Biol. Med. 127, 132 (1968).Google Scholar
  500. [435]
    K. Toki, T. Fukumaru, H. Nakatani, and H. Fukushima, J. Atherosclerosis Res. 7, 708 (1967).Google Scholar
  501. [436]
    Sumitomo Chem. Co. Ltd., Neth. Appl. 6,505,431 (1965); Chem. Abs. 64, 14137c (1966).Google Scholar
  502. [437]
    M. D. Siperstein, C. W. Nichols, Jr., and I. L. Chaikoff, Science 117, 386 (1953).Google Scholar
  503. [438]
    P. Griminger and H. Fischer, Proc. Soc. Exptl. Biol. Med. 99, 424 (1958).Google Scholar
  504. [439]
    A. Keys, F. Grande, and J. T. Anderson, Proc. Soc. Exptl. Biol. Med. 106, 555 (1961).Google Scholar
  505. [440]
    D. M. Tennent, H. Siegel, M. E. Zanetti, G. W. Kuron, W. H. Ott, and F. J. Wolf, J. Lipid Res. 1, 469 (1960).Google Scholar
  506. [441]
    D. G. Gallo, R. W. Harkins, A. L. Sheffner, H. P. Sarett, and W. M. Cox, Jr., Proc. Soc. Exptl. Biol. Med. 122, 328 (1966).Google Scholar
  507. [442]
    S. A. Hashim and T. B. van Itallie, J. Am. Med. Assoc. 192, 289 (1965).Google Scholar
  508. [443]
    F. Bergmann and W. van der Linden, Gastroenterology 53, 418 (1968).Google Scholar
  509. [444]
    D. S. Goodman and R. P. Nobe, J. Clin. Invest. 47, 231 (1968).Google Scholar
  510. [445]
    H. R. Casdorph, Circulation 36, Suppl. II, 6 (1967).Google Scholar
  511. [446]
    H. J. Fallon and J. W. Woods, J. Am. Med. Assoc. 204, 1161 (1968).Google Scholar
  512. [447]
    A. K. Khachadurian, Abstracts 3rd International Symposium on Drugs Affecting Lipid Metabolism, p. 136 (Milan 1968).Google Scholar
  513. [448]
    J. W. Gofman and R. K. Tandy, Atheriosclerotic Vascular Disease, p. 162 (Eds. A. N. Brest and J. H. Moyer; Appleton-Century-Crofts, New York 1967).Google Scholar
  514. [449]
    L. E. Schaefer, Ann. N. Y. Acad. Sci. 148, 925 (1968).Google Scholar
  515. [450]
    E. Renk and W. G. Stoll, Progress in Drug Research, vol. 11, p. 226 (Ed. E. Jucker; Birkhäuser Verlag, Basel 1968).Google Scholar
  516. [451]
    S. Dack, Atherosclerotic Vascular Disease, p. 339 (Eds. A. N. Brest and J. H. Moyer; Appleton-Century-Crofts, New York 1967).Google Scholar

Copyright information

© Birkhäuser Verlag Basel 1969

Authors and Affiliations

  1. 1.Research Department CIBA Pharmaceutical CompanySummitUSA
  2. 2.Research Laboratories of the Pharmaceutical Department of CIBA Limited BaselSwitzerland

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