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Comparative Drug Metabolism

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Book cover Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Abstract

The tradition of testing the poisonous properties of food and drink by administering the material to animals extends back through the history of mankind. In some civilizations the expediency of employing human beings as professional ‘tasters’ was an acceptable practice. The use of humans for this sort of testing is unacceptable under present-day moral and ethical values. When we adopt the approach that animal testing may predict pharmacological or toxicological responses for man, we do so from a conviction that there is a common-ground plan for all living matter. Indeed, the major biochemical discoveries of the last three decades lend support for this conviction. As we have come to use animals more to predict the response of humans to drugs, we have come to realize that the similarities between animals and man are great, but so are the differences. In a phrase, we have become pharmacologically sophisticated.

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References

  1. Adrien Albert, Selective Toxicity, 2nd ed. (Methuen & Co. Ltd., London, John Wiley and Sons, Inc., New York 1960).

    Google Scholar 

  2. Earl H. Dearborn, Fed. Proc. 26, 1075 (1967), Symposium on Comparative Pharmacology.

    Google Scholar 

  3. R. T. Williams, Clin. Pharmac. Ther. 4, 234 (1963).

    Google Scholar 

  4. L. S. Shanker, Pharmac. Rev. 14, 501 (1962).

    Google Scholar 

  5. R. R. Levine and E. Pelikan, Ann. Rev. Pharmac. 4, 69 (1964).

    Google Scholar 

  6. T. Koppanyi and M. A. Avery, Clin. Pharmac. Ther. 7, 250 (1966).

    Google Scholar 

  7. T. C. Butler, Fed. Proc. 17, 1158 (1958).

    Google Scholar 

  8. B. B. Brodie, J. Axelrod, J. R. Cooper, L. E. Gaudette, B. N. La Du, C. Mitoma and S. Udenfriend, Science 121, 603 (1955).

    Google Scholar 

  9. B. B. Brodie, J. R. Gillette and B. N. La Du, Ann. Rev. Biochem. 27, 427 (1958).

    Google Scholar 

  10. J. R. Fouts, Fed. Proc. 21, 1107 (1962).

    Google Scholar 

  11. A. H. Conney and J. J. Burns, Adv. Pharmac. 1, 31 (1962).

    Google Scholar 

  12. H. Remmer and H. J. Merker, Ann. N. Y. Acad. Sci. 123, 79 (1965).

    Google Scholar 

  13. J. R. Fouts and L. G. Hart, Ann. N. Y. Acad. Sci. 123, 245 (1965).

    Google Scholar 

  14. R. L. Dixon, L. G. Hart and J. R. Fouts, J. Pharmac. exp. Ther. 133, 7 (1961).

    Google Scholar 

  15. B. B. Brodie, J. J. Burns and M. Weiner, Med. exp. 1, 290 (1959).

    Google Scholar 

  16. A. H. Conney, Pharmac. Rev. 19, 317 (1967).

    Google Scholar 

  17. L. B. Mellett and J. Strobel, Bull., Problems of Drug Dependence, Natl. Acad. Sci.—Natl. Res. Council 5376 (1968).

    Google Scholar 

  18. H. G. O. Holck, M. A. Kanan, L. Mills and E. L. Smith, J. Pharmac. 1, 152 (1958).

    Google Scholar 

  19. G. P. Quinn, J. Axelrod and B. B. Brodie, Biochem. Pharmac. 1, 152 (1958).

    Google Scholar 

  20. D. V. Parke, The Biochemistry of Foreign Compounds (Pergamon Press, London 1968).

    Google Scholar 

  21. J. R. Gillette, Progress in Drug Research, 6, 11 (Ed. E. Jucker; Birkhäuser Verlag, Basel 1963).

    Google Scholar 

  22. R. T. Williams, Detoxication Mechanism, 2nd ed. (John Wiley and Sons, New York 1959).

    Google Scholar 

  23. J. N. Smith, Comparative Biochemistry 6, 403 (Ed. Marcel Florkin and Howard S. Mason; Academic Press, New York 1964).

    Google Scholar 

  24. B. B. Brodie and W. D. Reid, Fed. Proc. 29, 1062 (1967).

    Google Scholar 

  25. R. T. Williams, Fed. Proc. 29, 1029 (1967).

    Google Scholar 

  26. J. R. Cooper and B. B. Brodie, J. Pharmac. exp. Ther. 114, 409 (1955).

    Google Scholar 

  27. J. R. Cooper and B. B. Brodie, J. Pharmac. exp. Ther. 120, 75 (1957).

    Google Scholar 

  28. F. L. M. Pattison, W. C. Howell and R. W. White, J. Am. chem. Soc. 78, 3487 (1956).

    Google Scholar 

  29. P. K. Gessner, D. V. Parke and R. T. Williams, Biochem. J. 79, 482 (1961).

    Google Scholar 

  30. H. W. Gerarde and D. W. Ahlstrom, Toxic, appl. Pharmac. 9, 185 (1966).

    Google Scholar 

  31. D. V. Parke, Biochem. J. 77, 493 (1960).

    Google Scholar 

  32. A. H. Conney, Fed. Proc. 26, 1027 (1967).

    Google Scholar 

  33. R. Kuntzman, M. Jacobsen, K. Schneidman and A. H. Conney, J. Pharmac. exp. Ther. 146, 280 (1964).

    Google Scholar 

  34. R. Kuntzman, R. Welch and A. H. Conney, Advan. Enzyme Regulation 4, 149 (1966).

    Google Scholar 

  35. S. D. Murphy and K. P. Dubois, J. Pharmac. exp. Ther. 124, 194 (1958).

    Google Scholar 

  36. J. L. Potter and R. D. O’Brien, Science 144, 55 (1964).

    Google Scholar 

  37. R. K. Maller and C. Heidelberger, Cancer Res. 17, 296 (1957).

    Google Scholar 

  38. A. N. Craig and H. Jackson, Biochem. Pharmac. 3, 42 (1959).

    Google Scholar 

  39. L. B. Mellett and L. A. Woods, Cancer Res. 20, 524 (1960).

    Google Scholar 

  40. L. B. Mellett, P. E. Hodgson and L. A. Woods, J. Lab. clin. Med. 60, 818 (1962).

    Google Scholar 

  41. J. Reventos, J. Pharm. Pharmac. 6, 217 (1954).

    Google Scholar 

  42. V. Williams and F. E. Shideman, J. Pharmac. exp. Ther. 101, 84A (1958).

    Google Scholar 

  43. M. T. Bush and E. Saunders, Ann. Rev. Pharmac. 7, 57 (1967).

    Google Scholar 

  44. N. P. Salzman and B. B. Brodie, J. Pharmac. exp. Ther. 118, 46 (1956).

    Google Scholar 

  45. J. L. Emmerson and T. S. Miya, J. Pharmac. exp. Ther. 137, 148 (1962).

    Google Scholar 

  46. R. T. Williams and D. V. Parke, Ann. Rev. Pharmac. 4, 85 (1964).

    Google Scholar 

  47. C. H. March and H. W. Elliott, Proc. Soc. exp. Biol. 86, 494 (1954).

    Google Scholar 

  48. A. L. Misra, S. J. Mulé and L. A. Woods, Nature 190, 82 (1961).

    Google Scholar 

  49. L. B. Mellett and L. A. Woods, Proc. Soc. exp. Biol. 106, 221 (1961).

    Google Scholar 

  50. H. W. Elliott, B. M. Tolbert, T. K. Adler and H. H. Anderson, Proc. Soc. exp. Biol. 85, 77 (1954).

    Google Scholar 

  51. J. R. Gillette, Fed. Proc. 26, 1040 (1967).

    Google Scholar 

  52. J. Cochin, J. Haggart, L. A. Woods and M. H. Seevers, J. Pharmac. exp. Ther. 111, 74 (1954).

    Google Scholar 

  53. L. B. Mellett and L. A. Woods, J. Pharmac. exp. Ther. 116, 77 (1956).

    Google Scholar 

  54. L. A. Woods, L. B. Mellett and K. S. Andersen, J. Pharmac. exp. Ther. 124, 1 (1958).

    Google Scholar 

  55. L. A. Woods, H. E. Muhlenbeck and L. B. Mellett, J. Pharmac. exp. Ther. 117, 117 (1956).

    Google Scholar 

  56. E. L. Way and T. K. Adler, Bull. Wld Hlth Org. 26, 51 (1962).

    Google Scholar 

  57. J. R. Fouts, J. J. Kamm and B. B. Brodie, J. Pharmac. exp. Ther. 120, 291 (1957).

    Google Scholar 

  58. R. H. Adamson, Fed. Proc. 26, 1047 (1967).

    Google Scholar 

  59. R. H. Adamson, R. L. Dixon, F. L. Francis and D. P. Rall, Proc. natn. Acad. Sci. 54, 1386 (1965).

    Google Scholar 

  60. B. B. Brodie, P. A. Lief and R. Poet, J. Pharmac. Exp. Ther. 94, 359 (1948).

    Google Scholar 

  61. B. B. Brodie and W. D. Reid, Fed. Proc. 26, 1062 (1967).

    Google Scholar 

  62. R. D. O’Brien, Ann. N. Y. Acad. Sci. 123, 156 (1965).

    Google Scholar 

  63. A. Albert, Ann. N. Y. Acad. Sci. 123, 5 (1965).

    Google Scholar 

  64. W. Kalow, Ann. Rev. Pharmac. 5, 9 (1965).

    Google Scholar 

  65. L. B. Mellett, S. M. Eldareer, D. P. Rall and R. H. Adamson, Archs int. Pharmacodyn. Thér. 177, 60 (1969).

    Google Scholar 

  66. J. P. Saunders, Fed. Proc. 26, 1071 (1967).

    Google Scholar 

  67. L. B. Mellett (unpublished observations).

    Google Scholar 

  68. W. J. Hayes Jr., The Insecticide Dichlorodiphenyltrichloroethane and Its Significance (Ed. P. Müller; Birkhäuser, Basel 1959).

    Google Scholar 

  69. R. T. Williams, Biogenesis of Natural Compounds (Ed. P. Bernfeld; Pergamon Press, London 1963).

    Google Scholar 

  70. E. Boyland, D. Manson and S. F. D. Orr, Biochem. J. 65, 417 (1957).

    Google Scholar 

  71. W. Keller, Annalen 43, 108 (1842).

    Google Scholar 

  72. J. N. Smith, Comparative Biochemistry, 6 (Ed. M. Florkin and H. S. Mason; Academic Press, 1965).

    Google Scholar 

  73. M. Hitchcock and J. N. Smith, Biochem. J. 93, 392 (1964).

    Google Scholar 

  74. E. Boyland, Proc. 1st Int. Pharmac. Meeting, Stockholm, 6, 65 (1962).

    Google Scholar 

  75. H. G. Bray, B. G. Humphris, W. V. Thorpe, K. White and P. B. Wood, Biochem, J. 52, 419 (1952).

    Google Scholar 

  76. P. K. Knoefel, K. C. Haung and A. Despopoulos, Am. J. Physiol. 196, 1224 (1959).

    Google Scholar 

  77. H. G. Bray, B. G. Humphris, W. V. Thorpe, K. White and P. B. Wood, Biochem. J. 59, 162 (1955).

    Google Scholar 

  78. Conference on Non-Human Primate Toxicology (Ed. Clem. O. Miller; U.S. Dept. of Health, Education & Welfare, 1966).

    Google Scholar 

  79. J. R. Gillette, Fed. Proc. 26, 1040 (1967).

    Google Scholar 

  80. J. A. Shannon, Harvey Lectures, Ser. 42, 43 (1945–1946).

    Google Scholar 

  81. T. C. Butler, Conference on Non-Human Primate Toxicology (Ed. Clem. O. Miller; U. S. Dept. of Health, Education & Welfare, 1966).

    Google Scholar 

  82. D. Pinkel, Cancer Res. 18, 853 (1958).

    Google Scholar 

  83. M. Rubner, Z. Biol. 19, 535 (1883).

    Google Scholar 

  84. E. Dubois, Basal Metabolism in Health and Disease (Lea and Febiger, Philadelphia 1936).

    Google Scholar 

  85. G. Dreyer and W. Ray, Phil. Trans. R. Soc, London [B] 201, 133 (1910).

    Google Scholar 

  86. G. Dreyer and W. Ray, Phil. Trans. R. Soc, London [B] 202, 191 (1911).

    Google Scholar 

  87. J. Gibson and W. Evans Jr., J. Clin. Invest. 16, 317 (1937).

    Google Scholar 

  88. G. Griffin, W. Abbott, M. Pride, E. Muntwyler, F. Mautz and L. Griffith, Ann. Surg. 121, 352 (1945).

    Google Scholar 

  89. R. J. Baker, D. Kozoll and K. A. Meyer, Surgery Gynec. Obstet. 104, 183 (1957).

    Google Scholar 

  90. A. Grollman, Am. J. Physiol. 90, 210 (1929).

    Google Scholar 

  91. H. W. Smith, The Kidney, Structure and Function in Health and Disease (Oxford University Press, New York 1951).

    Google Scholar 

  92. E. F. Adolph, Science 109, 579 (1949).

    Google Scholar 

  93. D. V. Lindley, J. R. statist. Soc. Supp. 9, 218 (1947).

    Google Scholar 

  94. N. Talbot, J. Crawford and A. Butler, New Eng. J. Med. 248, 1100 (1953).

    Google Scholar 

  95. E. J. Freireich, E. A. Gehan, D. P. Rall, L. H. Schmidt and H. E. Skipper, Cancer Chemother. Rep. 50, 219 (1966).

    Google Scholar 

  96. L.B. Mellett, Fed. Proc. 22, 305 (1963).

    Google Scholar 

  97. L. B. Mellett, as quoted by J. P. Saunders, Fed. Proc. 26, 1071 (1967).

    Google Scholar 

  98. L. B. Mellett (unpublished data).

    Google Scholar 

  99. J. G. Wagner and R. E. Damiano, J. clin. Pharmac. 8, 102 (1968).

    Google Scholar 

  100. E. S. Henderson, R. H. Adamson and V. T. Oliverio, Cancer Res. 25, 1018 (1965).

    Google Scholar 

  101. E. S. Henderson, R. H. Adamson, C. Denham and V. T. Oliverio, Cancer Res. 25, 1008 (1965).

    Google Scholar 

  102. L. B. Mellett (unpublished data).

    Google Scholar 

  103. J. D. Crawford, M. E. Terry and G. M. Rourke, Pediatrics 5, 783 (1950).

    Google Scholar 

  104. N. B. Eddy and D. Leimbach, J. Pharmac. exp. Ther. 107, 385 (1953).

    Google Scholar 

  105. L. B. Mellett and L. A. Woods, Progress in Drug Research 5, 158 (Ed. E. Jucker; Birkhäuser Verlag, Basel 1963).

    Google Scholar 

  106. J. Jaffee, Pharmacological Basis of Therapeutics, 3rd ed. (Ed. L. S. Goodman and A. Gilman; McMillan Co., New York 1965).

    Google Scholar 

  107. G. T. Okita, Fed. Proc. 26, 1125 (1967).

    Google Scholar 

  108. J. J. Burns, Conference on Non-Human Primate Toxicology, 86 (Ed. Clem. O.Miller, Dept. of Health, Education & Welfare, 1966).

    Google Scholar 

  109. J. R. Gillette, Ann. N. Y. Acad. Sci. 123, 42 (1965).

    Google Scholar 

  110. L. B. Mellett and J. Strobel, Bull., Problems of Drug Dependence, Natl. Acad. Sci.-Natl. Res. Council, Appendix 14, 5388 (1968).

    Google Scholar 

  111. J. H. Peters, Am. Rev. resp. Dis. 81, 485 (1960).

    Google Scholar 

  112. W. E. Bleidner, J. B. Harmon, W. E. Hewes, T. E. Tynes and E. C. Hermann, J. Pharmac. exp. Ther. 150, 484 (1965).

    Google Scholar 

  113. G. W. Camiener and C. G. Smith, Biochem. Pharmac. 14, 1405 (1965).

    Google Scholar 

  114. L. T. Mulligan and L. B. Mellett, Pharmacologist 10, 167 (1968).

    Google Scholar 

  115. M. B. Chenoweth, Pharmac. Rev. 1, 383 (1949).

    Google Scholar 

  116. E. A. Carr, Fed. Proc. 26, 1089 (1967).

    Google Scholar 

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  1. Kettering-Meyer Laboratories, Southern Research Institute, Birmingham, Alabama, USA

    Lawrence B. Mellett

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  1. Basel, Switzerland

    Ernst Jucker

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Mellett, L.B. (1969). Comparative Drug Metabolism. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 13. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7068-9_3

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  • DOI: https://doi.org/10.1007/978-3-0348-7068-9_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7070-2

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