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The Pharmacology of Homologous Series

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Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques

Abstract

It is the common practice of organic chemists who are concerned with the discovery of new drugs to take some compound which is known, or has been unexpectantly found, to possess some interesting or clinically desirable pharmacological properties, as a model, and to study the effect of making relatively small changes in its structure. The simplest chemical change that can be made is to alter the size of an alkyl group or of a polymethylene chain; in other words to investigate the pharmacology of a homologous series. An investigation of this type not only has practical advantages, such as ease of preparation of homologues, the small changes in physical and chemical properties involved, etc. but also it has frequently led to the discovery of highly active drugs. Moreover there is the theoretical likelihood that a detailed study of homologous compounds may reveal mechanisms of drug action which could not be revealed by a study of drugs differing more fundamentally in structure.

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Authors and Affiliations

  1. Department of Pharmacology, Oxford University, UK

    H. R. Ing

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  1. H. R. Ing
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Editors and Affiliations

  1. Pharmazeutisch-chemische Forschungslaboratorien, Sandoz AG, Basel, Schweiz

    Ernst Jucker

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© 1964 Birkhäuser Verlag Basel

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Ing, H.R. (1964). The Pharmacology of Homologous Series. In: Jucker, E. (eds) Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques. Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrés des recherches pharmaceutiques, vol 7. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7053-5_5

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  • DOI: https://doi.org/10.1007/978-3-0348-7053-5_5

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7055-9

  • Online ISBN: 978-3-0348-7053-5

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