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Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques pp 11–57Cite as

Basic Mechanisms of Drug Action

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Abstract

Pharmacologists have long cherished the hope that it might be possible to discover and state in precise terms some general theory to explain the mode of action of various drugs at the cellular or subcellular level. As our understanding of molecular pharmacodynamics has increased, the possibility of achieving this goal has become more remote. At the present time it would even be hazardous to attempt to set forth general principles of drug action. It is the aim of this review to discuss some of the recent attempts to reveal the basic mechanisms of drug action. Of course, there is still a host of drugs whose mechanism of action is completely obscure, but there is less tendency today to blanket ignorance with meaningless terms. For example, the cryptic term ‘protoplasmic poison’ which so frequently appeared under the heading of ‘mechanism of action’ in leading textbooks of pharmacology until a few years ago, has now become obsolete.

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References

  1. L. V. Heilbrunn, The Viscosity of Protoplasm, Protoplasmatologia, Vol. 2, C1 (Springer-Verlag, Vienna 1958), p. 89.

    Google Scholar 

  2. J. F. Danielli, Cell Physiology and Pharmacology (Elsevier Publishing Co. Inc., New York 1950), pp. 75–78.

    Google Scholar 

  3. A. D. Welch and E. Bueding, in Currents in Biochemical Research, Ed. by D. E. Green (Interscience Publishers Inc., New York 1946), p. 401.

    Google Scholar 

  4. J. J. Burns and P. A. Shore, Ann. Rev. Pharmacol. 1 (1961), 79.

    Google Scholar 

  5. J. A. Bain and S. E. Mayer, Ann. Rev. Pharmacol. 2 (1962), 37.

    Google Scholar 

  6. A. V. S. de Reuck, Enzymes and Drug Action (Little, Brown and Co., Boston 1962).

    Google Scholar 

  7. A. White, P. Handler, E. L. Smith, and De W. Stetten, Jr., Principles of Biochemistry, 2nd Ed. (McGraw-Hill Book Co. Inc., New York 1959), p. 246 et seq.

    Google Scholar 

  8. H. L. Segal, in The Enzymes, 2nd Ed., Ed. by P. D. Boyer, H. Lardy, and K. Myrbäck, Vol. 1 (Academic Press Inc., New York 1959), p. 1.

    Google Scholar 

  9. Documenta Geigy, Scientific Tables, 5th Ed. (New York 1959), p. 469.

    Google Scholar 

  10. R. J. Winzler, J. Cell. Comp. Physiol. 21 (1943), 229.

    Google Scholar 

  11. D. W. Woolley, in Progress in Drug Research, Vol. 2, Ed. by E. Jucker (Birkhäuser Verlag, Basel 1960), p. 613.

    Google Scholar 

  12. A. Albert, Selective Toxicity (John Wiley and Sons Inc., New York 1960), p. 103.

    Google Scholar 

  13. D. D. Woods, Brit. J. Exp. Path. 21 (1940), 74.

    Google Scholar 

  14. A. Albert, Selective Toxicity (John Wiley and Sons Inc., New York 1960), p. 50.

    Google Scholar 

  15. J. N. Stannard, Am. J. Physiol. 126 (1939), 196.

    Google Scholar 

  16. K. C. Fisher, Can. Med. Assoc. J. 47 (1942), 414.

    Google Scholar 

  17. W. D. McElroy, Quart. Rev. Biol. 22 (1947), 25.

    Google Scholar 

  18. H. McIlwain, Biochem. J. 49 (1951), 382.

    Google Scholar 

  19. H. McIlwain, Biochem. J. 53 (1953), 403.

    Google Scholar 

  20. W. N. Aldridge and V. H. Parker, Biochem. J. 76 (1960), 47.

    Google Scholar 

  21. F. E. Shideman and M. H. Seevers, J. Pharm. Expt. Therap. 74 (1942), 88.

    Google Scholar 

  22. C. L. Gemmill, Biochim. Biophys. Acta 4 (1950), 138.

    Google Scholar 

  23. T. M. Brody and J. A. Bain, Proc. Soc. Exp. Biol. Med. 77 (1951), 50.

    Google Scholar 

  24. T. M. Brody, Pharm. Rev. 7 (1955), 335.

    Google Scholar 

  25. W. N. Aldridge in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 155.

    Google Scholar 

  26. J. R. Fouts, Federation Proc. 21 (1962), 1107.

    Google Scholar 

  27. H. Remmer, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 398.

    Google Scholar 

  28. J. R. Fouts, Biochem. Biophys. Res. Commun. 6 (1961), 373.

    Google Scholar 

  29. D. Nachmansohn, Anesthesiology 20 (1959), 421.

    Google Scholar 

  30. F. E. Hunter, Jr., and O. H. Lowry, Pharm. Rev. 8 (1956), 89.

    Google Scholar 

  31. R. W. Berliner and J. Orloff, Pharm. Rev. 8 (1956), 137.

    Google Scholar 

  32. H. W. Davenport, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 16.

    Google Scholar 

  33. J. Sicé, General Pharmacology (Saunders, Philadelphia 1962), p. 40.

    Google Scholar 

  34. R. T. Williams, Detoxication Mechanisms, 2nd Ed. (John Wiley and Sons, New York 1959).

    Google Scholar 

  35. N. J. Harper, in Progress in Drug Research, Vol. 4, Ed. by E. Jucker (Birkhäuser-Verlag, Basel 1962), p. 221.

    Google Scholar 

  36. B. B. Brodie, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 317.

    Google Scholar 

  37. W. H. Fishman, Chemistry of Drug Metabolism (Charles C. Thomas, Springfield 1961).

    Google Scholar 

  38. B. B. Brodie, J. Pharm. Pharmacol. 8 (1956), 1.

    Google Scholar 

  39. H. Remmer, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 276.

    Google Scholar 

  40. R. Kato, in Neuro-Psychopharmacology, Vol. 2, Ed. by E. Rothin (Elsevier Publishing Co. Inc., New York 1961), p. 57.

    Google Scholar 

  41. A. H. Conney, E. C. Miller, and J. A. Miller, Cancer Res. 16 (1956), 450.

    Google Scholar 

  42. A. H. Conney, C. Davison, R. Gastel, and J. J. Burns, J. Pharm. Expt. Therap. 130 (1960), 1.

    Google Scholar 

  43. J. Axelrod, Science 124 (1956), 263.

    Google Scholar 

  44. A. E. Takemori, Science 133 (1961), 1018; J. Pharm. Expt. Therap. 135 (1962), 89.

    Google Scholar 

  45. D. B. Goldstein and A. Goldstein, Biochem. Pharmacol. 8 (1961), 48.

    Google Scholar 

  46. J. A. Gunn, Physiol. Rev. 3 (1923), 41.

    Google Scholar 

  47. P. B. Sawin and D. Glick, Proc. Nat. Acad. Sci. 29 (1943), 55.

    Google Scholar 

  48. M. R. Pollack, in Resistance of Bacteria to the Penicillins, Ed. by A. V. S. de Reuck and M. P. Cameron (Little, Brown and Co., Boston 1962), p. 56.

    Google Scholar 

  49. M. R. Pollack, in Drug Resistance in Micro-organisms, Ed. by G. E. W. Wolstenholme and C. M. O’Connor (Little, Brown and Co., Boston 1957), p. 78.

    Google Scholar 

  50. P. E. Carson, Federation Proc. 19 (1960), 995.

    Google Scholar 

  51. A. R. Tarlov and R. W. Kellermeyer, J. Lab. Clin. Med. 58 (1961), 204.

    Google Scholar 

  52. H. Harris and M. Whittaker, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 301.

    Google Scholar 

  53. R. O. Davies, A. V. Marton, and W. Kalow, Can. J. Biochem. Physiol. 38 (1960), 545.

    Google Scholar 

  54. A. Albert, Selective Toxicity (John Wiley and Sons Inc., New York 1960), p. 39 et seq.

    Google Scholar 

  55. A. J. Clark, General Pharmacology, Handbuch der experimentellen Pharmakologie, Vol. 4 (Springer-Verlag, Berlin 1937).

    Google Scholar 

  56. E. J. Ariëns, Proceedings Int. Union of Physiological Sciences Vol. 7, Part II (1962), p. 824.

    Google Scholar 

  57. E. J. Ariëns, Acta Phys. Pharm. Neer. 11 (1962), 151.

    Google Scholar 

  58. E. J. Ariëns and A. M. Simonis, in Quantitative Methods in Pharmacology, Ed. by H. de Jonge (Interscience Publishers Inc., New York 1961), p. 286.

    Google Scholar 

  59. R. P. Stephenson, Brit. J. Pharmacol. 11 (1956), 379.

    Google Scholar 

  60. W. D. M. Paton, Proc. Royal Soc. (London) B 154 (1961), 21.

    Google Scholar 

  61. R. Croxatto and F. Huidobro, Arch. int. Pharmacodyn. 106 (1956), 207.

    Google Scholar 

  62. McK. Cattell and H. Goodell, Science 86 (1937), 106.

    Google Scholar 

  63. D. R. H. Gourley, Unpublished results.

    Google Scholar 

  64. D. R. H. Gourley, Am. J. Physiol. 200 (1961), 1320.

    Google Scholar 

  65. D. E. Koshland, Jr., Biochem. Pharmacol. 8 (1961), 57.

    Google Scholar 

  66. K. Landsteiner, The Specificity of Serological Reactions (Harvard University Press, Cambridge 1945).

    Google Scholar 

  67. D. Pressman, Proceedings Int. Union of Physiological Sciences Vol. 1, Part II (1962), p. 819.

    Google Scholar 

  68. A. L. Grossberg and D. Pressman, J. Am. Chem. Soc. 82 (1960), 5478.

    Google Scholar 

  69. D. Pressman and O. Roholt, Proc. Nat. Acad. Sci. 47 (1961), 1606.

    Google Scholar 

  70. M. L. Bender, Chem. Rev. 60 (1960), 53.

    Google Scholar 

  71. E. M. Kosower, Molecular Biochemistry (McGraw-Hill Book Co., New York 1962).

    Google Scholar 

  72. R. L. Hill and E. L. Smith, Biochim. Biophys. Acta 19 (1956), 376.

    Google Scholar 

  73. G. E. Perlmann, Nature 173 (1954), 406.

    Google Scholar 

  74. D. E. Koshland, Jr., Proc. Nat. Acad. Sci. 44 (1958), 98.

    Google Scholar 

  75. S. L. Friess, Curare and Curare-like Agents (Little, Brown and Co., Boston 1962), p. 93.

    Google Scholar 

  76. D. E. Koshland, Jr., J. A. Yankeelov, Jr., and J. A. Thoma, Federation Proc. 21 (1962), 1031.

    Google Scholar 

  77. B. R. Baker, W. W. Lee, W. A. Skinner, A. P. Martinez, and E. Tong, J. Med. Pharm. Chem. 2 (1960), 633.

    Google Scholar 

  78. H. McIlwain, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 170.

    Google Scholar 

  79. J. C. Skou, Biochim. Biophys. Acta 42 (1960), 6.

    Google Scholar 

  80. E. T. Dunham and I. M. Glynn, J. Physiol. 156 (1961), 274.

    Google Scholar 

  81. R. L. Post, C. R. Merritt, C. R. Kinsolving, and C. D. Albright, J. Biol. Chem. 235 (1960), 1796.

    Google Scholar 

  82. M. Weatherall, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 115.

    Google Scholar 

  83. H. J. Schatzmann, Nature 196 (1962), 677.

    Google Scholar 

  84. A. V. S. de Reuck, Enzymes and Drug Action (Little, Brown and Co., Boston 1962), pp. 439–443.

    Google Scholar 

  85. F. Bergel, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 440.

    Google Scholar 

  86. D. Nachmansohn, Chemical and Molecular Basis of Nerve Activity (Academic Press, New York 1959).

    Google Scholar 

  87. I. B. Wilson, in Molecular Biology, Ed. by D. Nachmansohn (Academic Press, New York 1960), p. 163.

    Google Scholar 

  88. P. G. Waser, Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 206.

    Google Scholar 

  89. S. Ehrenpreis, Science 129 (1959), 1613; Biochim. Biophys. Acta 44 (1960), 561.

    Google Scholar 

  90. S. Ehrenpreis, Science 136 (1962), 175.

    Google Scholar 

  91. D. Nachmansohn, Science 136 (1962), 177.

    Google Scholar 

  92. A. H. Beckett and A. F. Casy, J. Pharm., Pharmacol. 6 (1954), 986.

    Google Scholar 

  93. A. H. Beckett, A. F. Casy, N. J. Harper, and P. M. Phillips, J. Pharm. Pharmacol. 8 (1956), 860.

    Google Scholar 

  94. A. H. Beckett, in Progress in Drug Research, Vol. 1, Ed. by E. Jucker (Birkhäuser-Verlag, Basel 1959), p. 455.

    Google Scholar 

  95. A. H. Beckett, Proceedings Int. Union of Physiological Sciences, Vol. 1, Part II (1962), p. 805.

    Google Scholar 

  96. J. Kalvoda, P. Buchschacher, and O. Jeger, Helv. Chim. Acta 38 (1955), 1847.

    Google Scholar 

  97. H. Corrodi and E. Hardegger, Helv. Chim. Acta 38 (1955), 2038.

    Google Scholar 

  98. A. H. Beckett, A. F. Casy, and N. J. Harper, J. Pharm. Pharmacol. 8 (1956), 874.

    Google Scholar 

  99. C. Elison, H. Rapaport, R. Laursen, and H. W. Elliott, Science 134 (1961), 1078.

    Google Scholar 

  100. J. W. Miller and H. H. Anderson, J. Pharmacol. Exper. Therap. 112 (1954), 191.

    Google Scholar 

  101. P. A. J. Janssen, A. H. M. Jagenau, P. J. A. Demden, C. van de Westeringh, A. H. M. Raeymaekers, M. S. J. Wouters, S. Sanczuk, B. K. F. Hermans, and J. L. M. Loomans, J. Med. Pharm. Chem. 1 (1959), 105.

    Google Scholar 

  102. A. H. Bsceckett, N. J. Harper, J. W. Clitherow, and E. Lesser, Nature 189 (1961), 671.

    Google Scholar 

  103. V. B. Schatz, in Medicinal Chemistry, 2nd Ed., Ed. by A. Burger (Interscience Publishers, New York 1960), p. 72.

    Google Scholar 

  104. B. Belleau, Can. J. Biochem. Physiol. 36 (1958), 731.

    Google Scholar 

  105. B. Belleau, in Ciba Foundation Symposium on Adrenergic Mechanisms, Ed. by G. E. W. Wolstenholme and M. O’Connor (Little, Brown and Co., Boston 1960), p. 223.

    Google Scholar 

  106. B. Belleau, in Proceedings of the First International Pharmacological Meeting, Vol. 7, Ed. by B. Uvnäs (Pergamon Press, New York 1963), p. 75.

    Google Scholar 

  107. B. Belleau, J. Burba, M. Pindell, and J. Reiffenstein, Science 133 (1961), 102.

    Google Scholar 

  108. B. Belleau and J. Burba, Biochim. Biophys. Acta 54 (1961), 195.

    Google Scholar 

  109. H. Rasmussen, I. L. Schwartz, M. A. Schoessler, and G. Hochster, Proc. Nat. Acad. Science 46 (1960), 1278.

    Google Scholar 

  110. I. L. Schwartz, H. Rasmussen, M. A. Schoessler, L. Silver, and C. T. O. Fong, Proc. Nat. Acad. Sciences 46 (1960), 1288.

    Google Scholar 

  111. C. T. O. Fong, L. Silver, D. R. Christman, and I. L. Schwartz, Proc. Nat. Acad. Science 46 (1960), 1273.

    Google Scholar 

  112. R. Levine and M. S. Goldstein, Rec. Progress Horm. Res. 11 (1955), 343.

    Google Scholar 

  113. J. F. Manery, D. R. H. Gourley, and K. C. Fisher, Can. J. Biochem. Physiol. 34 (1956), 893.

    Google Scholar 

  114. W. C. Stadie, N. Haugaard, J. B, Marsh, and A. G. Hills, Am. J. Med. Sciences 218 (1949), 265.

    Google Scholar 

  115. D. R. H. Gourley, Am. J. Physiol. 189 (1957), 489.

    Google Scholar 

  116. H. E. Morgan, M. J. Henderson, D. M. Regen, and C. R. Park, J. Biol. Chem. 236 (1961), 253.

    Google Scholar 

  117. E. Cadenas, H. Kaji, C. R. Park, and H. Rasmussen, J. Biol. Chem. 236 (1961), PC 63.

    Google Scholar 

  118. K. Hofmann, Ann. Rev. Biochem. 31 (1962), 213.

    Google Scholar 

  119. Hofmann, Brookhaven Symp. in Biol. 13 (1960), 184.

    Google Scholar 

  120. J. Ferguson, Proc. Roy. Soc. (London) B 127 (1939), 387.

    Google Scholar 

  121. L. Pauling, Science 134 (1961), 15.

    Google Scholar 

  122. S. L. Miller, Proc. Nat. Acad. Sci. 47 (1961), 1515.

    Google Scholar 

  123. J. F. Brown, Jr., Scientific Am. 207, No. 1 (1962), 82.

    Google Scholar 

  124. A. J. Clark, General Pharmacology, Handbuch der experimentellen Pharmakologie, Vol. 4 (Springer-Verlag, Berlin 1937), p. 28.

    Google Scholar 

  125. F._J. Brinley, Proc. Soc. Exp. Biol. Med. 25 (1928), 305; J. Gen. Physiol. 12 (1928), 201.

    Google Scholar 

  126. R. P. Cook, J. Physiol. 62 (1926), 160.

    Google Scholar 

  127. B. Katz, Johns Hopkins Hosp. Bull. 102, (1958), 296.

    Google Scholar 

  128. P. C. Caldwell and R. D. Keynes, J. Physiol. 148 (1959), 8 P.

    Google Scholar 

  129. Symposium on the Plasma Membrane, Circulation it26 (1962), 983.

    Google Scholar 

  130. G. E. Palade and K. R. Porter, J. Exp. Med. 100 (1954), 641.

    Google Scholar 

  131. K. R. Porter, Harvey Lectures 51 (1955–56), 175.

    Google Scholar 

  132. H. Davson, Circulation 26 (1962), 1022.

    Google Scholar 

  133. A. S. V. Burgen, Can. J. Biochem. Physiol. 40 (1962), 1253.

    Google Scholar 

  134. J. F. Danielli, in Surface Phenomena in Chemistry and Biology, Ed. by J. F. Danielli, K. G. A. Pankhurst, and A. C. Riddiford (Pergamon Press, New York 1958), p. 246.

    Google Scholar 

  135. P. Kruhøffer, J. Pharm. Pharmacol. 13 (1961), 193.

    Google Scholar 

  136. Mck. Cattell and H. Goodell, Science 86 (1937), 106.

    Google Scholar 

  137. H. J. Schatzmann, Helv. Physiol. Pharmacol. Acta 11 (1953), 346.

    Google Scholar 

  138. A. K. Solomon, T. J. Gill, 3rd, and G. L. Gold, J. Gen. Physiol. 40 (1956), 327.

    Google Scholar 

  139. H. Passow, A. Rothstein, and T. W. Clarkson, Pharmacol. Rev. 13 (1961), 185.

    Google Scholar 

  140. J. C. Skou, J. Pharm. Pharmacol. 13 (1961), 204.

    Google Scholar 

  141. H. Davson, A Textbook of General Physiology, 2nd Ed. (Little, Brown and Co., Boston 1959), p. 246.

    Google Scholar 

  142. A. M. Shanes, Pharmacol. Rev. 10 (1958), 59.

    Google Scholar 

  143. A. M. Shanes and N. L. Gershfield, J. Gen. Physiol. 44 (1960), 345.

    Google Scholar 

  144. S. Dikstein, in Quantitative Methods in Pharmacology, Ed. by H. de Jonge (Interscience Publishers Inc., New York 1961), p. 312; in Biophysics of Physiological and Pharmacological Actions, Ed. by A. M. Shanes (American Association for the Advancement of Science, Washington 1961), p. 49.

    Google Scholar 

  145. O. Stein and J. Gross, Endocrinol. 65 (1959), 707.

    Google Scholar 

  146. DeW. Stetten, Jr., Science 124 (1956), 365.

    Google Scholar 

  147. H. Lineweaver and D. Burk, J. Am. Chem. Soc. 56 (1934), 658.

    Google Scholar 

  148. D. R. H. Gourley and K. C. Fisher, Am. J. Physiol. 179 (1954), 378.

    Google Scholar 

  149. D. R. H. Gourley, Am. J. Physiol. 189 (1957), 489.

    Google Scholar 

  150. D. E. Koshland, Jr., J. Cell. Comp. Physiol. 54, Supp. 1 (1959), 245.

    Google Scholar 

  151. R. J. Barrnett and E. G. Ball, J. Biophy. Biochem. Cytol. 8 (1960), 83.

    Google Scholar 

  152. H. Holter and H. Holtzer, Exp. Cell Res. 18 (1959), 421.

    Google Scholar 

  153. H. Holter, in Enzymes and Drug Action, Ed. by A. V. S. de Reuck (Little, Brown and Co., Boston 1962), p. 30.

    Google Scholar 

  154. D. A. Goldstein and A. K. Solomon, J. Gen. Physiol. 44 (1960), 1.

    Google Scholar 

  155. G. Whittembury, J. Gen. Physiol. 46 (1962), 117.

    Google Scholar 

  156. G. Whittembury, N. Sugino, and A. K. Solomon, Nature 187 (1960), 699.

    Google Scholar 

  157. A. Albert, Selective Toxicity (John Wiley and Sons, New York 1960), p. 136.

    Google Scholar 

  158. P. H. Plotz and B. D. Davis, Science 135 (1962), 1067.

    Google Scholar 

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  1. Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    D. R. H. Gourley

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  1. Pharmazeutisch-chemische Forschungslaboratorien, Sandoz AG, Basel, Schweiz

    Ernst Jucker

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Gourley, D.R.H. (1964). Basic Mechanisms of Drug Action. In: Jucker, E. (eds) Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques. Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrés des recherches pharmaceutiques, vol 7. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7053-5_1

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