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Molecular Geometry and Mechanisms of Action of Chemical Carcinogens

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Book cover Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques

Part of the book series: Progress in Drug Research ((PDR,volume 4))

Abstract

Since the discovery, between 1930 and 1940, of the carcinogenic activity of certain polycyclic aromatic hydrocarbons and azo dyes, innumerable chemical agents have been tested. It is probably not exaggerated to say that at the pre-sent time the number of known ways of tumor induction approaches a thousand and includes such heterogenous etiologic factors as structurally defined chemical carcinogens, chemical agents of unknown composition, carcinogenic viruses, physical agents, and various types of experimentally produced systemic hor-monal imbalances. Until about 1950, however, the classification of chemical carcinogens was relatively simple since a great majority of the compounds could be grouped either as condensed aromatic polycyclic hydrocarbons or as aromatic amines, this last group including the benzacridines and the amino azo dyes. Various theories were proposed to account for the tumor producing ability of chemicals falling into these two categories. A limited correlation was established between reactivity in terms of π-electron distribution of certain molecular regions and the carcinogenic activity of angular polycyclic aromatic hydrocarbons and benzacridines. Attempts were subsequently made to include amino azo dyes and other aromatic amines in these theories.

Published literature available to the authors through August, 1961, has been consi-dered in the preparation of this article.

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References

  1. N. K. Adam, ‘The Physics and Chemistry of Solids’, Oxford Univ. Press, 1941, p. 90

    Google Scholar 

  2. T. Addis, L. J. Poo and W. Lew, J. Biol. Chem. 115, 111 (1936).

    Google Scholar 

  3. A. C. Aisenberg, Cancer Research 21, 295 (1961).

    Google Scholar 

  4. H. Akamatu and H. Inokuchi, in ‘Proceedings 3rd Conf. on Carbon’, Pergamon Press, London, 1953, p. 51.

    Google Scholar 

  5. H. Akamatu, H. Inokuchi, and Y. Matsunaga, Bull. Chem. Soc. Japan 29, 213 (1956).

    Google Scholar 

  6. A. Albert, Nature 182, 421 (1958).

    Google Scholar 

  7. A. Albert, ‘Selective Toxicity’, John Wiley, New York, 1960, p. 196.

    Google Scholar 

  8. A. Albert, S. D. Rubbo, M. J. Burvill, Brit. J. Exp. Path. 30, 159 (1949).

    Google Scholar 

  9. M. D. Albert and N. L. R. Bucher, Cancer Research 20, 1514 (1960).

    Google Scholar 

  10. P. Alexander, Adv. Cancer Res. 2, 2 (1954).

    Google Scholar 

  11. P. Alexander, in comments, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 24.

    Google Scholar 

  12. P. Alexander, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 195.

    Google Scholar 

  13. P. Alexander, S. F. Cousens, and K. A. Stacey, in ‘Drug Resistance in Micro-Organisms’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1957, p. 249.

    Google Scholar 

  14. P. Alexander and E. S. Horning, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 12.

    Google Scholar 

  15. P. Alexander and J. T. Lett, Biochem. Pharmacol. 4, 34 (1960).

    Google Scholar 

  16. P. Alexander and K. A. Stacey, Proc. 4th Intern. Congr. Biochem., Vienna, Vol. IX, Pergamon, London, 1959, p. 98.

    Google Scholar 

  17. M. J. Allen, E. Boyland, C. E. Dukes, E. S. Horning, and J. G. Watson, Brit. J. Cancer 11, 212 (1957).

    Google Scholar 

  18. M. J. Allen, E. Boyland, and G. Watson, 34th Ann. Rep. Brit. Emp. Cancer Campaign, 1956, p. 35.

    Google Scholar 

  19. V. G. Allfrey and A. E. Mirsky, Proc. Natl. Acad. Sci. 43, 821 (1957), and Trans. N. Y. Acad. Sci., Ser. II, 21, 3 (1958).

    Google Scholar 

  20. M. M. Allingham, C. H. Giles, and E. L. Neustädter, Disc. Faraday Soc., No. 16, 92 (1954).

    Google Scholar 

  21. A. C. Allison and J. W. Lightbown, Nature 189, 892 (1961).

    Google Scholar 

  22. A. M. Ambrose, F. DeEds, and L. J. Rather, J. Ind. Hyg. Toxicol. 31, 158 (1949).

    Google Scholar 

  23. E. J. Ambrose, Brit. J. Cancer 8, 259 (1954).

    Google Scholar 

  24. E. J. Ambrose, D. M. Easty, and P. C. T. Jones, Brit. J. Cancer 12, 439 (1958).

    Google Scholar 

  25. N. G. Anderson and W. D. Fisher, Exp. Cell Res. 22, 13 (1961).

    Google Scholar 

  26. N. G. Anderson, W. D. Fisher, and H. E. Bond, Ann. N. Y. Acad. Sci, 90, 345 (1960).

    Google Scholar 

  27. H. B. Andervont and M. B. Shimkin, J. Natl. Cancer Inst. 1, 225 (1940).

    Google Scholar 

  28. J. C. Arcos, Bull. Tulane Univ. Med. Fac. 20, 133 (1961)

    Google Scholar 

  29. J. C. Arcos and M. Arcos, Compt. Rend. 241, 777 (1955).

    Google Scholar 

  30. J. C. Arcos and M. Arcos, Naturwiss. 42, 608 (1955).

    Google Scholar 

  31. J. C. Arcos and M. Arcos, Naturwiss. 42, 651 (1955).

    Google Scholar 

  32. J. C. Arcos and M. Arcos, Bull. Soc. Chim. Belges 65, 5 (1956).

    Google Scholar 

  33. J. C. Arcos and M. Arcos, Rev. Fermentations (Belgium) 11, 127 (1956).

    Google Scholar 

  34. J. C. Arcos and M. Arcos, Naturwiss. 44, 331, 332 (1957).

    Google Scholar 

  35. J. C. Arcos and M. Arcos, Arzneimittelforsch. 8, 602 (1958).

    Google Scholar 

  36. J. C. Arcos and M. Arcos, Biochim. Biophys. Acta 28, 9 (1958).

    Google Scholar 

  37. J. C. Arcos, M. Arcos, N. P. Buu-Hoi, and A. Lacassagne, Compt. Rend. 241, 836 (1955).

    Google Scholar 

  38. J. C. Arcos, M. Arcos and J. A. Miller, J. Org. Chem. 21, 651 (1956).

    Google Scholar 

  39. J.C. Arcos, A. H. Conney, and N. P. Buu-Hoi, J. Biol. Chem. 236, 1291 (1961).

    Google Scholar 

  40. J. C. Arcos, H. H. Gosch, and D. Zickafoose, J. Biophys. Biochem. Cytol. 10, 23 (1961).

    Google Scholar 

  41. J. C. Arcos and G. W. Griffith, Brit. J. Cancer 15, 291 (1961).

    Google Scholar 

  42. J. C. Arcos, G. W. Griffith, and R. W. Cunningham, Experientia 15, 316 (1959).

    Google Scholar 

  43. J. C. Arcos, G. W. Griffith, and R. W. Cunningham, J. Biophys. Biochem. Cytol. 7, 49 (1960).

    Google Scholar 

  44. J. C. Arcos and J. A. Miller, J. Am. Chem. Soc. 77, 3128 (1955).

    Google Scholar 

  45. J. C. Arcos and J. Simon, Arzneimittelforsch., 12, 270 (1962).

    Google Scholar 

  46. M. Arcos, unpublished results.

    Google Scholar 

  47. M. Arcos and J. C. Arcos, Rev. Gen. Sci. and Bull. Assoc. Fran. Avanc. Sci. 63, 89 (1956).

    Google Scholar 

  48. M. Arcos and J. C. Arcos, Compt. Rend. 245, 1092 (1957).

    Google Scholar 

  49. M. Arcos and J. C. Arcos, Arzneimittelforsch. 8, 486 (1958).

    Google Scholar 

  50. M. Arcos and J. C. Arcos, Arzneimittelforsch. 8, 643 (1958).

    Google Scholar 

  51. E. Arffmann, J. Natl. Cancer Inst. 25, 893 (1960).

    Google Scholar 

  52. M. F. Argus and C. Hoch-Ligeti, J. Natl. Cancer Inst. 27, 695 (1961).

    Google Scholar 

  53. M.F. Argus, J.F.Kane, M. Sakuntala, and F. E. Ray, Radiation Research, 16, 37 (1962).

    Google Scholar 

  54. M. F. Argus, C. J. Leutze, and J. F. Kane, Experientia 17, 357 (1961).

    Google Scholar 

  55. M. F. Argus and F. E. Ray, Nature 184, 2018 (1959)

    Google Scholar 

  56. E. Arrhenius and T. Hultin, Exp. Cell. Res. 22, 476 (1961).

    Google Scholar 

  57. W. R. Ashby, ‘An Introduction to Cybernetics’, John Wiley, New York, 1958.

    Google Scholar 

  58. Atomic Energy Commission (USA), Special Report in Physical and Life Sciences, January 1961, p. 61.

    Google Scholar 

  59. C. Auerbach and J. M. Robson, Proc. Roy. Soc. Edinburgh B62, 271 (1947).

    Google Scholar 

  60. L. Augenstine, in ‘Information Theory in Biology’, H. Quastler, Editor, Univ. Illinois Press, Urbana, 1953.

    Google Scholar 

  61. Y. Avi-Dor, Biochim. Biophys. Acta 39, 53 (1960).

    Google Scholar 

  62. Z. M. Bacq: ‘Travaux récents sur les toxiques de guerre», Series «ctualités Bio-chimiques’, Masson Publ., Paris, 1947.

    Google Scholar 

  63. G. M. Badger, Brit. J. Cancer 2, 309 (1948).

    Google Scholar 

  64. G. M. Badger, J. Chem. Soc. 456 (1949); 1809 (1950).

    Google Scholar 

  65. G. M. Badger, Adv. Cancer Res. 2, 73 (1954).

    Google Scholar 

  66. G. M. Badger, Brit. J. Cancer 10, 330 (1956).

    Google Scholar 

  67. G. M. Badger, J. W. Cook, C. L. Hewett, E. L. Kennaway, N. M. Kennaway, and R. H. Martin, Proc. Roy. Soc. B131, 170 (1942).

    Google Scholar 

  68. G. M. Badger, J. W. Cook, C. L. Hewett, E. L. Kennaway, N. M. Kennaway, R. H. Martin, and A. M. Robinson, Proc. Roy. Soc. B 129, 439 (1940).

    Google Scholar 

  69. G. M. Badger and G. E. Lewis, Brit. J. Cancer 4, 270 (1952).

    Google Scholar 

  70. G. M. Badger, R. S. Pearce, and R. Pettit, J. Chem. Soc. 1112 (1952).

    Google Scholar 

  71. K. Baker, Acta Un. Intern. Cancrum 7, 46 (1950), and Cancer Research 13,137 (1953).

    Google Scholar 

  72. R.W.Baldwin, K.Butler, F. C. Cooper, M. W. Partridge and G. J. Cunning-ham, Nature 181, 838 (1958).

    Google Scholar 

  73. R.W.Baldwin, G.J.Cunningham, and M. W. Partridge, Brit. J. Cancer 13, 94 (1959).

    Google Scholar 

  74. T.E. Banks, J. C. Boursnell, G.E.Francis, F. L. Hopwood, and A.Wormall, Biochem. J. 40, 745 (1946).

    Google Scholar 

  75. T. J. Bardos, H.J.Gordon, and E. F. Heenan, J.Am. Chem. Soc. 77, 3115 (1955).

    Google Scholar 

  76. G. Barry, J.W.Cook, G. A. D. Haslewood, C. L. Hewett, I. Hieger, and E.L. Kennaway, Proc. Roy. Soc. B117, 318 (1935).

    Google Scholar 

  77. M. Bassi, Exp. Cell. Res. 20, 313 (1960).

    Google Scholar 

  78. O. Bastiansen, Acta Chem. Scandinav. 3, 408 (1949).

    Google Scholar 

  79. C. T. Beer, F. Dickens, and J. Pearson, Biochem. J. 48, 222 (1951). [80] M. Beer, P. J. Highton, and B. J. McCarthy, 5th. Ann. Meet., The Biophysical Society, St. Louis, 1961, Abstract SC 7.

    Google Scholar 

  80. I. Berenblum, unpublished, cited in Reference [392], p. 479.

    Google Scholar 

  81. I. Berenblum, Brit. J. Exp. Path. 10, 179 (1929).

    Google Scholar 

  82. I. Berenblum, unpublished, cited in L. F. Fieser and E. B. Hershberg, J. Am. Chem. Soc. 63, 251 (1941).

    Google Scholar 

  83. I. Berenblum, 24th Ann. Rep., Brit. Emp. Cancer Campaign, p. 126 (1947).

    Google Scholar 

  84. I. Berenblum, A. M. Kaye, and N. Trainin, Cancer Research 20, 38 (1960).

    Google Scholar 

  85. I. Berenblum and A. Wormall, Biochem. J. 33, 75 (1939).

    Google Scholar 

  86. M. Berenbom, Cancer Research 19, 1045 (1959).

    Google Scholar 

  87. L. van den Berg and D. Rose, Arch. Biochezm. Biophys. 81, 319 (1959).

    Google Scholar 

  88. F. Bergmann, Cancer Research 2, 660 (1942).

    Google Scholar 

  89. E. A. Bering and A. H. Handler, Cancer 10, 414 (1957).

    Google Scholar 

  90. W. Bernhard, Cancer Research 18, 491 (1958). [92] E. Beutz, 5th Ann. Meet., The Biophysical Society, St. Louis, Mo., 1961, Abstract TA1.

    Google Scholar 

  91. R. E. Beyer, S. L. Lamberg, and M. A. Neyman, Canad. J. Biochem. 39, 73 (1961).

    Google Scholar 

  92. P. M. Bhargava, H. I. HaDler, and C. Heidelberger, J. Am. Chem. Soc. 77, 2877 (1955).

    Google Scholar 

  93. P. M. Bhargava and C. Heidelberger, J. Am. Chem. Soc. 78, 3671 (1956).

    Google Scholar 

  94. H. Bielka, A. Graffi, and W. Krischke, Naturwiss. 44, 381 (1957).

    Google Scholar 

  95. F. Bielschowsky, Brit. J. Exp. Path. 27, 54, 135 (1946).

    Google Scholar 

  96. F. Bielschowsky, Progr. Med. 3, 79 (1949).

    Google Scholar 

  97. F. Bielschowsky and M. Bielschowsky, Brit. J. Cancer 6, 89 (1952).

    Google Scholar 

  98. J. J. Biesele, Ann. N. Y. Acad. Sci. 71, 1054 (1958).

    Google Scholar 

  99. J. J. Biesele, in ‘Frontiers in Cytology’, S. L. Palay, Editor, Yale Univ. Press, 1958, p. 84.

    Google Scholar 

  100. J. J. Biesele, ‘Mitotic Poisons and the Cancer Problem’, Elsevier, New York, 1958.

    Google Scholar 

  101. J. J. Biesele, F. S. Philips, J. B. Thiersch, J. H. Burchenal, S. M. Buckley, and C. C. Stock, Nature 166, 1112 (1950).

    Google Scholar 

  102. J. B. Birks, Disc. Faraday Soc. 27, 243 (1959).

    Google Scholar 

  103. J. B. Birks, Nature 190, 232 (1961).

    Google Scholar 

  104. H. F. Blum, Science 118, 197 (1953).

    Google Scholar 

  105. M. Blumer, Science 134, 474 (1961).

    Google Scholar 

  106. F. G. Bock and M. Burnham, Cancer Research 21, 510 (1961).

    Google Scholar 

  107. F. G. Bock and D. W. King, J. Natl. Cancer Inst. 23, 833 (1959).

    Google Scholar 

  108. G. M. Bonser, L. Bradshaw, D. B. Clayson, and J. W. Jull, Brit. J. Cancer 10, 539 (1956).

    Google Scholar 

  109. G. M. Bonser, L. Bradshaw, D. B. Clayson, and J. W. Jull, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 197.

    Google Scholar 

  110. G. M. Bonser, D. B. Clayson, and J. W. Jull, Lancet, ii, 286 (1951).

    Google Scholar 

  111. G. M. Bonser, D. B. Clayson, and J. W. Jull, Nature 174, 879 (1954).

    Google Scholar 

  112. G. M. Bonser, D. B. Clayson, and J. W. Jull, Brit. Med. Bull. 14, 146 (1958).

    Google Scholar 

  113. G. M. Bonser, D. B. Clayson, J. W. Jull, and L. N. Pyrah, Brit. J. Cancer 6, 412 (1952).

    Google Scholar 

  114. G. M. Bonser, D. B. Clayson, J.W. Jull, and L.N. Pyrah, Brit. J. Cancer 10, 533 (1956).

    Google Scholar 

  115. J. Booth and E. Boyland, Biochim. Biophys. Acta 12, 75 (1953).

    Google Scholar 

  116. J. Booth, E. Boyland, and S. F. D. Orr, J. Chem. Soc, 598 (1954).

    Google Scholar 

  117. J. C. Boursnell, J. A. Cohen, M. Dixon, G. E. Francis, G. D. Greville, D. M Needham, and A. Wormall, Biochem. J. 40, 756 (1946).

    Google Scholar 

  118. J. C. Boursnell, G. E. Francis, and A. Wormall, Biochem. J. 40, 737, 765, 768, 774 (1946).

    Google Scholar 

  119. R. K. Boutwell and D. K. Bosch, Cancer Research 19, 413 (1959).

    Google Scholar 

  120. R. K. Boutwell, D. Bosch and H. P. Rusch, Cancer Research 17, 71 (1957).

    Google Scholar 

  121. P. Bovet, Schweiz. Ztschr. allg. Path. Bakt. 15, 548 (1952).

    Google Scholar 

  122. E. Boyland, J. Chim. Phys. 47, 942 (1950).

    Google Scholar 

  123. E. Boyland, Cancer Research 12, 77 (1952).

    Google Scholar 

  124. E. Boyland, Pharmacol. Rev. 6, 345 (1954).

    Google Scholar 

  125. E. Boyland, in ‘Causation of Cancer’, Brit. Med. Bull. 14, 153 (1958).

    Google Scholar 

  126. E. Boyland, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 218.

    Google Scholar 

  127. E. Boyland and A. M. Brues, Proc. Roy. Soc. B122, 429 (1937).

    Google Scholar 

  128. E. Boyland, J. Harris, and E. S. Horning, Brit. J. Cancer 8, 647 (1954).

    Google Scholar 

  129. E. Boyland and E. Horning, Brit. J. Cancer 3, 118 (1949).

    Google Scholar 

  130. E. Boyland and D. Manson, Biochem. J. 60, ii (1955).

    Google Scholar 

  131. E. Boyland and S. Sargent, Brit. J. Cancer 5, 433 (1951).

    Google Scholar 

  132. E. Boyland and G. Watson, Nature 177, 837 (1956).

    Google Scholar 

  133. J. T. Bradbury, W. E. Bachman, and M. G. Lewisohn, Cancer Research 1, 685 (1941).

    Google Scholar 

  134. R. B. Bradbury and C. C. J. Culvenor, Chem. Ind. 33, 1021 (1954).

    Google Scholar 

  135. W. Bradley, Nature 137, 404 (1936).

    Google Scholar 

  136. L. Bradshaw and D. B. Clayson, Nature 176, 974 (1955).

    Google Scholar 

  137. E. A. Braude, Experientia 11, 457 (1955).

    Google Scholar 

  138. A. W. Breidenbach and M. F. Argus, Quart. J. Florida Acad. Sci. 19, 68 (1956).

    Google Scholar 

  139. S. Brenner and J. Gillman, South African J. Med. Sci. 17, 81 (1952).

    Google Scholar 

  140. N. Brock, H. Druckrey, and H. Hamperl, Arch. exp. Path. Pharmakol. 189, 709 (1938).

    Google Scholar 

  141. W. R. Brode, ‘Steric Effects in Dyes’ in ‘Roger Adams Symposium’, John Wiley, New York, 1955.

    Google Scholar 

  142. S. `Brody, Nature 182, 1386 (1958).

    Google Scholar 

  143. S. Brody, Cancer Research 20, 1469 (1960).

    Google Scholar 

  144. S. Brody and M. E. Balis, Cancer Research 19, 538 (1959).

    Google Scholar 

  145. T. M. Brody, Federation Proc. 18, 1017 (1959).

    Google Scholar 

  146. E. V. Brown, R. Faessinger, P. Malloy, J. T. Travers, P. McCarthy, and L. R. Cerecedo, Cancer Research 14, 22 (1954).

    Google Scholar 

  147. E. V. Brown and A. A. Hamdam, J. Natl. Cancer Inst. 27, 663 (1961).

    Google Scholar 

  148. C. H. Browning, J. B. Cohen, K. E. Cooper, S. Ellingworth, and R. Gulbransen, Proc. Roy. Soc. B113, 300 (1933).

    Google Scholar 

  149. G. F. Buckley and W. S. Hartroft, A. M. A. Arch. Path. 59, 185 (1955).

    Google Scholar 

  150. L. B. Bull, A. T. Dick, J. C. Keast, and G. Edgar, Australian J. Agri. Res. 7, 281 (1956)

    Google Scholar 

  151. H. B. Burch, F. E. Hunter, A. M. Combs, and B. A. Schutz, J. Biol. Chem. 235, 1540 (1960).

    Google Scholar 

  152. W. J. Burdette, J. Natl. Cancer Inst. 9, 105 (1948).

    Google Scholar 

  153. W. J. Burdette, Cancer Research 15, 201 (1955).

    Google Scholar 

  154. R. E. Burk and O. Grummitt, Editors, ‘High Molecular Weight Organic Compounds’, Interscience, New York, 1949.

    Google Scholar 

  155. W. T. Burke and L. L. Miller, Cancer Research 19, 148 (1959).

    Google Scholar 

  156. R. K. Burkhard, R. Bauer, and D. Klaassen, 140th Meet. Am. Chem. Soc, Chicago 1961, Abstract No. 173, Section 71C.

    Google Scholar 

  157. H. Burton and S. B. David, J. Chem. Soc, 2193 (1952).

    Google Scholar 

  158. H. Busch and J. R. Davis, Cancer Research 18, 1241 (1958).

    Google Scholar 

  159. A. Butenandt, E. BiCKERT, and G. Neubert, Ann. Chem. 602, 72 (1957).

    Google Scholar 

  160. J. A. V. Butler, P. Cohn, and P. Simson, Biochim. Biophys. Acta 38, 386 (1960).

    Google Scholar 

  161. J. A. V. Butler, E. M. Press, and D. W. F. James, 2nd Intern. Congr. Biochem., Paris, 1952, Abstract p. 462.

    Google Scholar 

  162. J. M. Butros, Cancer Research 8, 347 (1948).

    Google Scholar 

  163. N. P. Buu-Hoi, Acta Un. Intern. Cancrum 7, 68 (1950).

    Google Scholar 

  164. N. P. Buu-Hoi, Arzneimittelforsch. 4, 531 (1954).

    Google Scholar 

  165. N. P. Buu-Hoi, Strahlentherapie 98, 3 (1955), also 126th Meet. Am. Chem. Soc, New York, 1954, Abstract No. 8, Section N.

    Google Scholar 

  166. N. P. Buu-Hoi, Arzneimittelforsch. 6, 251 (1956).

    Google Scholar 

  167. D. N. Calvert and T. M. Brody, J. Pharmacol. Exp. Therap. 124, 273 (1958).

    Google Scholar 

  168. D. N. Calvert and T. M. Brody, Am. J. Physiol. 198, 669 (1960).

    Google Scholar 

  169. J. G. Campbell, Proc. Roy. Soc. Edinburgh B66, 111 (1956).

    Google Scholar 

  170. C. H. Carlisle and D. Crowfoot, J. Chem. Soc. 67, 6 (1941).

    Google Scholar 

  171. C. Carruthers, V. Suntzeff, and P. N. Harris, Cancer Research 14, 845 (1954).

    Google Scholar 

  172. R. A. M. Case, M. E. Hosker, D. B. MacDonald, and J. T. Pearson, Brit. J. industr. Med. 11, 75 (1954).

    Google Scholar 

  173. L. F. Cavalieri, R. Finston, and B. H. Rosenberg, Nature 189, 833 (1961).

    Google Scholar 

  174. D. CavAllini, B. Mondovi, B. Giovanella, and C. DeMarco, Science 131, 1441 (1960).

    Google Scholar 

  175. J. G. Chalmers, Brit. J. Cancer 9, 320 (1955).

    Google Scholar 

  176. O. Chalvet and R. Daudel, Acta Un. Intern. Cancrum 15, 577 (1959).

    Google Scholar 

  177. O. Chalvet, R. Daudel, and C.Moser, Cancer Research 18, 1033 (1958), and Compt. Rend. 246, 3457 (1958).

    Google Scholar 

  178. O. Chalvet and Shou-Sin Sung, Compt. Rend. 251, 2092 (1960).

    Google Scholar 

  179. J. Chambron and C. Sadron, Compt. Rend. 252, 3247 (1961).

    Google Scholar 

  180. D. F. Cheesman, Biochem. J. 56, XL ii (1954), and Adv. Protein Chem. 9, 440 (1954).

    Google Scholar 

  181. D. F. Cheesman, M. M. Keeler, and O. Sten-Knudsen, Biochem. J. 72, 357 (1959).

    Google Scholar 

  182. G. S. Christie, Australian J. Exp. Biol. Med. Sci. 36, 413 (1958).

    Google Scholar 

  183. G. S. Christie and J. D. Judah, Proc. Roy. Soc B142, 241 (1954).

    Google Scholar 

  184. S. M. H. Christie, M. Kropman, E. C. Leisegang, and F. L. Warren, J. Chem. Soc, 1700 (1949); 702 (1950)

    Google Scholar 

  185. G. Cilento, Cancer Research 20, 120 (1960).

    Google Scholar 

  186. G. Cilento, E. C. Miller, and J. A. Miller, J. Am. Chem. Soc. 78, 1718 (1956).

    Google Scholar 

  187. G. Cilento, J.A.Miller, and E.C.Miller, Acta Un. Intern. Cancrum 11, 632 (1955).

    Google Scholar 

  188. E. Clar, ‘Aromatische Kohlenwasserstoffe. Polycyclische Systeme’, Springer, Ber-lin, 1952.

    Google Scholar 

  189. A. M. Clark, Nature 183, 731 (1959).

    Google Scholar 

  190. D. B. Clayson, Brit. J. Cancer 7, 460 (1953).

    Google Scholar 

  191. C. C. Clayton and L. D. Abbott, Cancer Research 18, 94 (1958).

    Google Scholar 

  192. E. Clerici and G. Cudkowicz, J. Natl. Cancer Inst. 16, 1459 (1956).

    Google Scholar 

  193. G. H. A. Clowes, W.W. Davis, and M. E. Krahl, Am. J. Cancer 36, 98 (1939); 37, 453 (1939).

    Google Scholar 

  194. P. Cohn and J. A. V. Butler, Biochem. J. 70, 254 (1958).

    Google Scholar 

  195. J. S. Colter and K. A. O. Ellem, Nature 190, 550 (1961).

    Google Scholar 

  196. D. R. Coman, Cancer Research 20, 1202 (1960).

    Google Scholar 

  197. D. R. Coman and T. F. Anderson, Cancer Research 15, 541 (1955).

    Google Scholar 

  198. A. H. Conney, personal communication.

    Google Scholar 

  199. A. H. Conney, R. R. Brown, J. A. Miller, and E. C. Miller, Cancer Research 17, 628 (1957).

    Google Scholar 

  200. A. H. Conney, E.C.Miller, and J.A.Miller, Cancer Research 16, 450 (1956).

    Google Scholar 

  201. A. H. Conney, E. C. Miller, and J. A. Miller, J. Biol. Chem. 228, 753 (1957).

    Google Scholar 

  202. J. W. Cook, Proc. Roy. Soc. B111, 485 (1932).

    Google Scholar 

  203. J. W. Cook, J. Chem. Soc. 1592 (1933).

    Google Scholar 

  204. J. W. Cook and E. C. Dodds, Nature 131, 205 (1933).

    Google Scholar 

  205. J. W. Cook, E. Duffy, and R. Schoental, Brit. J. Cancer 4, 405 (1950).

    Google Scholar 

  206. J. W. Cook, C. L. Hewett, E. L. Kennaway, and N. M. Kennaway, Am. J. Cancer 40, 62 (1940).

    Google Scholar 

  207. J. W. Cook, E. L. Kennaway, and N. M. Kennaway, Nature 145, 627 (1940).

    Google Scholar 

  208. J. W. Cook and R. Schoental, Brit. J. Cancer 6, 400 (1952).

    Google Scholar 

  209. D. H. Copeland and W. D. Salmon, Am. J. Path. 22, 1059 (1946).

    Google Scholar 

  210. C. A. Coulson, Adv. Cancer Res. 1, 1 (1953).

    Google Scholar 

  211. P. N. Cowen, Brit. J. Cancer 1, 401 (1947).

    Google Scholar 

  212. P. N. Cowen, Brit. J. Cancer 4, 245 (1950).

    Google Scholar 

  213. P. N. Cowen, Brit. J. Cancer 4, 337 (1950).

    Google Scholar 

  214. H. G. Crabtree, Brit. J. Cancer 3, 387 (1949).

    Google Scholar 

  215. F. D. Cramer, ‘Einschlussverbindungen’, Springer, Heidelberg, 1954.

    Google Scholar 

  216. F. D. Cramer, Rev. Pure & Appl. Chem. (Australia) 5, 143 (1955).

    Google Scholar 

  217. F. D. Cramer, Rec. Trav. Chim. 75, 891 (1956).

    Google Scholar 

  218. J. W. Cramer, J. A. Miller, and E. C. Miller, J. Biol. Chem. 235, 250 (1960).

    Google Scholar 

  219. E. M. H. Creech, Nature 138, 291 (1936), and Am. J. Cancer 35, 191 (1939) ; 39, 149 (1940).

    Google Scholar 

  220. R. S. Criddle and R. M. Bock, 139th Meet. Am. Chem. Soc, St. Louis, Mo., 1961, Abstract No. 90, p. 38C.

    Google Scholar 

  221. G. Crile, J. Natl. Cancer Inst. 20, 229 (1958).

    Google Scholar 

  222. G. Cudkowicz, Tumori 38, 176 (1952).

    Google Scholar 

  223. V. D’Amelio and P. Perlman, Exp. Cell Res. 19, 383 (1960).

    Google Scholar 

  224. I. Danishefsky, E. T. Oppenheimer, M. Willhite , A. P. Stout, and M. M. Fish-man, Cancer Research 19, 1234 (1959).

    Google Scholar 

  225. V. Darchun and H. I. Hadler, Cancer Research 16, 316 (1956).

    Google Scholar 

  226. C. D. Darlington, Editor, ‘Symposium on Chromosome Breakage’, Heredity, Suppl. 6, 315 (1953).

    Google Scholar 

  227. P. Daudel, B. Chenon, N. P. Buu-Hoi, P. Jacquignon, A. Lacassagne, G. Prodi, G. Vallee, R. Vasquez, and F. Zajdela, Bull. Soc. Chim. Biol. 42, 135 (1960).

    Google Scholar 

  228. P. Daudel and R. Daudel, Biol. Médicale 39, 1 (1950).

    Google Scholar 

  229. P.Daudel, F. Nectoux, L. Pichat, and G. Prodi, Compt. Rend. 251, 1049 (1960).

    Google Scholar 

  230. P. Daudel, G. Prodi, and B. Chenon, Compt. Rend. 248, 3238 (1959).

    Google Scholar 

  231. R. Daudel, Rev. Scientifique 84, 37 (1946).

    Google Scholar 

  232. J. N. Davidson, 15th Ann. Symp. on Fundamental Cancer Res., ‘The Molecular Basis of Neoplasia’, Houston, 1961, Abstract p. 15.

    Google Scholar 

  233. W. W. Davis, M. E. Krahl, and G. H. A. Clowes, J. Am. Chem. Soc. 62, 3080 (1940).

    Google Scholar 

  234. S. DeCarvalho, Proc. Am. Assoc. Cancer Res. 3, 218 (1961).

    Google Scholar 

  235. S. DeCarvalho and H. J. Rand, Nature 189, 815 (1961).

    Google Scholar 

  236. A. von der Decken and T. Hultin, Exp. Cell Res. 19, 591 (1960).

    Google Scholar 

  237. A. von der Decken, H. Low, and T. Hultin, Biochem. Ztschr. 332, 503 (1960).

    Google Scholar 

  238. W. B. Deichmann, W. M. MacDonald, M. M. Coplan, F. M. Woods, and W. A. D. Anderson, Industr. Med. Surg. 27, 634 (1958).

    Google Scholar 

  239. M. Delbrück and G. Sato, Science 122, 874 (1955).

    Google Scholar 

  240. G. Della Porta, Cancer Research 21, 575 (1961).

    Google Scholar 

  241. G. Della Porta, P. Shubik, K. DAmmert, and B. Terracini, J. Natl. Cancer Inst. 25, 607 (1960).

    Google Scholar 

  242. G. Della Porta, B. Terracini, and P. Shubik, J. Natl. Cancer Inst. 26, 855 (1961).

    Google Scholar 

  243. M. Demerec, G. Bertani, and J.Flint, Am. Naturalist 85, 119 (1951).

    Google Scholar 

  244. T. M. Devlin and G. E. Boxer, Proc. Am. Assoc. Cancer Res. 3, 220 (1961).

    Google Scholar 

  245. J. Dhar, Proc. Nat. Inst. Sci. India 15, 11 (1949).

    Google Scholar 

  246. M. U. Dianzani, Biochim. Biophys. Acta 14, 514 (1954).

    Google Scholar 

  247. F. Dickens and H. Weil-Malherbe, Cancer Research 2, 560 (1942); 6, 161 (1946).

    Google Scholar 

  248. C. Dittmar, Ztschr. Krebsforsch. 52, 17 (1942).

    Google Scholar 

  249. K. Dobriner, K. Hoffmann, and C. P. Rhoads, Science 93, 600 (1941).

    Google Scholar 

  250. E. C. Dodds, Brit. Med. Bull. 4, 378 (1946–47).

    Google Scholar 

  251. I. Doniach and J. C. Mottram, Am. J. Cancer 39, 234 (1940).

    Google Scholar 

  252. H. Druckrey, Acta Un. Intern. Cancrum 7, 116 (1950).

    Google Scholar 

  253. H. Druckrey, Arch. exp. Path. Pharmakol. 210, 137 (1950), and Arch. klin. Chirurg. 264, 45 (1950).

    Google Scholar 

  254. H. Druckrey, Arzneimittelforsch. 2, 503 (1952).

    Google Scholar 

  255. H. Druckrey, in comments, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foun-dation Symp., Little, Brown and Co., Boston, 1959, p. 24.

    Google Scholar 

  256. H. Druckrey, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 110.

    Google Scholar 

  257. H. Druckrey, R. Preussmann, D. Schmähl, and M. Müller, Naturwiss. 48, 134 (1961).

    Google Scholar 

  258. H. Druckrey and D. Schmähl, Ztschr. Naturforsch. 7 b, 353 (1952).

    Google Scholar 

  259. H. Druckrey and D. Schmähl, Naturwiss. 41, 534 (1954).

    Google Scholar 

  260. H. Druckrey and D. Schmähl, Naturwiss. 42, 159 (1955).

    Google Scholar 

  261. H. Druckrey and D. Schmähl, Naturwiss. 42, 215 (1955).

    Google Scholar 

  262. H. Druckrey, D. Schmähl, and P. Danneberg, Naturwiss. 39, 393 (1952).

    Google Scholar 

  263. H. Druckrey, D. Schmähl, and R. Mecke, Ztschr. Krebsforsch. 61, 55 (1956).

    Google Scholar 

  264. H. G. DuBuy and M. L. Hesselbach, J. Histochem. Cytochem. 4, 363 (1956).

    Google Scholar 

  265. H. G. DuBuy and M. L. Hesselbach, J. Natl. Cancer Inst. 20, 403 (1958).

    Google Scholar 

  266. H. G. DuBuy, M. W. Woods, and J. L. Showacre, in ‘Pigment Cell Growth’, M. Gordon, Editor, Acad. Press, New York, 1953, p. 335.

    Google Scholar 

  267. C. Dufraisse and I. Gillet, Compt. Rend. 225, 191 (1947).

    Google Scholar 

  268. C. E. Dunlap and S. Warren, Cancer Research 1, 730, 953 (1941).

    Google Scholar 

  269. W. F. Dunning and M. R. Curtis, J. Natl. Cancer Inst. 25, 387 (1960).

    Google Scholar 

  270. W. F. Dunning, M. R. Curtis, and F. D. Bullock, Am. J. Cancer 28, 681 (1936).

    Google Scholar 

  271. W. F. Dunning, M. R. Curtis, and M. E. Mann, Cancer Research 10, 454 (1950).

    Google Scholar 

  272. A. P. Dustin, in ‘Leukemia Research’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1954, p. 244.

    Google Scholar 

  273. H. J. Eckhardt, Ber. Deut. Chem. Ges. 73B, 13 (1940).

    Google Scholar 

  274. G. A. Edwards and J. Fogh, Cancer Research 19, 608 (1959).

    Google Scholar 

  275. J. E. Edwards, J. Natl. Cancer Inst. 2, 197 (1941).

    Google Scholar 

  276. J. E. Edwards, W. E. Heston, and A. J. Dalton, J. Natl. Cancer Inst. 3, 19, 297 (1942).

    Google Scholar 

  277. D. S. Egbert and A. J. Geiger, Am. Rev. Tuberculosis 34, 143 (1936).

    Google Scholar 

  278. P. Ehrlich and P. Doty, J. Am. Chem. Soc. 80, 4251 (1958).

    Google Scholar 

  279. B. Ekman and J. P. Strömbeck, Acta path. microbiol. Scandinav. 26, 795 (1949).

    Google Scholar 

  280. P. Ekwall, Acta Acad. Aboensis, Math. & Phys. 17, 1 (1951).

    Google Scholar 

  281. S. C. Ellis and K. G. A. Pankhurst, Disc. Faraday Soc. No. 16, 170 (1954).

    Google Scholar 

  282. L. A. Elson, Brit. J. Cancer 6, 392 (1952).

    Google Scholar 

  283. L. A. Elson and F. L. Warren, Biochem. J. 38, 217 (1944); and C. Hoch-Ligeti, Ibid. 40, 380 (1946).

    Google Scholar 

  284. P. Emmelot, Biochim. Biophys. Acta 23, 668 (1957).

    Google Scholar 

  285. P. Emmelot, Acta Un. Intern. Cancrum 14, 50 (1958).

    Google Scholar 

  286. P. Emmelot and E. L. Benedetti, J. Biophys. Biochem. Cytol. 7, 393 (1960).

    Google Scholar 

  287. P. Emmelot and E. L. Benedetti, in ‘Symposium on Protein Biosynthesis’, R. J. C. Harris, Editor, Acad. Press, New York, 1961, p. 99.

    Google Scholar 

  288. P. Emmelot and C. J. Bos, Rec. Trav. Chim. T74, 1343 (1955).

    Google Scholar 

  289. P. Emmelot and C. J. Bos, Biochim. Biophys. Acta 24, 442 (1957).

    Google Scholar 

  290. P. Emmelot and C. J. Bos, Exp. Cell Res. 12, 191 (1957).

    Google Scholar 

  291. P. Emmelot and C. J. Bos, Biochem. Pharmacol. 3, 244 (1960).

    Google Scholar 

  292. P. Emmelot, C. J. Bos, and I. H. M. Revers, Ztschr. Krebsforsch. 64, 52 (1960).

    Google Scholar 

  293. P. Emmelot and I. H. M. Reyers, Ztschr. Krebsforsch. 64, 35 (1960).

    Google Scholar 

  294. H. Engelhard and K. R. Eikenberg, Ztschr. Naturforsch. 11b, 625 (1956), and Naturwiss. 44, 283 (1957).

    Google Scholar 

  295. L. Ernster and F. Navazio, Acta Chem. Scandinav. 10, 1038 (1956).

    Google Scholar 

  296. G. J. van Esch, H. H. Vink, and H. van Genderen, Nature 180, 509 (1957).

    Google Scholar 

  297. A. B. Eschenbrenner, J. Natl. Cancer Inst. 4, 385 (1944).

    Google Scholar 

  298. A. B. Eschenbrenner and E. Miller, J. Natl. Cancer Inst. 6, 325 (1946).

    Google Scholar 

  299. E. Etienne, in ‘Traité de Chimie Organique’, V. Grignard, G. Dupont, and R. Loc-quin, Editors, 17, 1229 (1949), Masson, Paris.

    Google Scholar 

  300. M. Evans and J. Gergely, Biochim. Biophys. Acta 3, 188 (1949).

    Google Scholar 

  301. H. Eyring, R. Lumry, and J. D. Spikes, in ‘Symp. on the Mechanism of Enzyme Action’, W. D. McElroy and B. Glass, Editors, Johns Hopkins Press, Baltimore, 1954, p. 123.

    Google Scholar 

  302. J. van Eys, A. San Pietro, and N. O. Kaplan, Science 127, 1443 (1958).

    Google Scholar 

  303. O. G. Fahmy and M. J. Fahmy, Nature 191, 116 (1961).

    Google Scholar 

  304. H. L. Falk and P. Kotin, Proc. Am. Assoc. Cancer Res. 3, 223 (1961).

    Google Scholar 

  305. E. FArber, personal communication.

    Google Scholar 

  306. E. FArber, A. M. A. Arch. Path. 62, 445 (1956).

    Google Scholar 

  307. E. FArber and H. Ichinose, Cancer Research 10, 1209 (1958).

    Google Scholar 

  308. E. FArber and P. N. Magee, Biochem. J. 76, 58 P (1960).

    Google Scholar 

  309. J. C. Fardon, Science 117, 441 (1953).

    Google Scholar 

  310. H. B. Fell and C. B. Allsopp, Cancer Research 8, 177 (1948).

    Google Scholar 

  311. G. Felsenfeld and A. Rich, Biochim. Biophys. Acta 26, 457 (1957).

    Google Scholar 

  312. W. G. Ferrier and J. Iball, Chem. & Ind., 1926 (1954).

    Google Scholar 

  313. S. Fiala and A. E. Fiala, Brit. J. Cancer 13, 136 (1959).

    Google Scholar 

  314. L. F. Fieser, ‘Production of Cancer by Polynuclear Hydrocarbons’, Univ. of Pennsylvania Bicentennial Conference, Philadelphia, 1941.

    Google Scholar 

  315. L. F. Fieser, 1944 Rep. A.A.A.S. Conf. Cancer, Washington, 1945, p. 108.

    Google Scholar 

  316. L. F. Fieser, Science 119, 719 (1954).

    Google Scholar 

  317. L. F. Fieser and W. P. Campbell, J. Am. Chem. Soc. 60, 1142 (1938).

    Google Scholar 

  318. L. F. Fieser, T. W. Greene, F. Bischoff, G. Lopez, and J. J. Rupp, J. Am. Chem. Soc. 77, 3928 (1955).

    Google Scholar 

  319. L. F. Fieser and E. B. Hershberg, J. Am. Chem. Soc. 60, 1893, 2542 (1938).

    Google Scholar 

  320. L. F. Fieser and S. T. Putnam, J. Am. Chem. Soc. 69, 1041 (1947).

    Google Scholar 

  321. W. D. Fisher, N. G. Anderson, and K. M. Wilbur, Exp. Cell Res. 18, 100 (1959).

    Google Scholar 

  322. O. G. Fitzhugh and A. A. Nelson, J. Ind. Hyg. Toxicol. 28, 40 (1946), and Cancer Research 3, 230 (1943).

    Google Scholar 

  323. O. G. Fitzhugh and A. A. Nelson, Science 108, 626 (1948).

    Google Scholar 

  324. O. G. FiTZHUGH and A. A. Nelson, Federation Proc. 9, 272 (1950).

    Google Scholar 

  325. L. Fiume and G. Favilli, Nature 189, 71 (1961).

    Google Scholar 

  326. Th. Förster, ‘Fluoreszenz organischer Verbindungen’, Vandenhoeck & Ruprecht, Göttingen, 1950, p. 83.

    Google Scholar 

  327. E. Frederick, A. Oth, and V. Desreux, Biochem. Pharmacol. 4, 3 (1960).

    Google Scholar 

  328. A. Frey-Wyssling, ‘Submicroscopic Morphology of Protoplasm’, Elsevier, New York, 1952.

    Google Scholar 

  329. E. Frieden and J. Alles, J. Biol. Chem. 230, 797 (1958).

    Google Scholar 

  330. C. H. Gallagher, Biochem. Pharmacol. 3, 220 (1960).

    Google Scholar 

  331. W. U. Gardner, Adv. Cancer Res. 1, 173 (1953).

    Google Scholar 

  332. E. J. Gasson, H. McCombie, A. H. Williams, and F. N. Woodward, J. Chem. Soc, 44 (1948).

    Google Scholar 

  333. G. H. Gehrmann, J. H. Foulger, and A. J. Fleming, Proc. 9th Intern. Congr. Industr. Med., 473 (1949).

    Google Scholar 

  334. H. V. Gelboin, J. A. Miller, and E. C. Miller, Biochim. Biophys. Acta, 27, 655 (1958).

    Google Scholar 

  335. H. V. Gelboin, J. A. Miller, and E. C. Miller, Cancer Research 18, 608 (1958).

    Google Scholar 

  336. H. V. Gelboin, J. A. Miller, and E. C. Miller, Cancer Research 19, 975 (1959).

    Google Scholar 

  337. V. Ghiron, Proc. 3rd Intern. Cancer Congr., Atlantic City, 1939, Abstract p. 116.

    Google Scholar 

  338. G. Giacomello and E. Bianchi, Gaz. chim. ital. 71, 667 (1941).

    Google Scholar 

  339. C. H. Giles, T. J. Rose, and D. G. M. Vallance, J. Chem. Soc, 3799 (1952).

    Google Scholar 

  340. J. Gillman, C. Gilbert, T. Gillman, and I. Spence, South African Med. J. 22, 783 (1948).

    Google Scholar 

  341. J. Gillman and T. Gillman, Cancer 5, 792 (1952).

    Google Scholar 

  342. A. Gilman and F. S. Philips, Science 103, 409 (1946).

    Google Scholar 

  343. A. D. Glinos, in ‘Information Theory in Biology’, H. P. Yockey, Editor, Pergamon Press, New York, 1958, p. 148.

    Google Scholar 

  344. A. D. Glinos, N. L. R. Bucher, and J. C. Aub, J. Exp. Med. 93, 313 (1951).

    Google Scholar 

  345. V. Gold and F. L. Tye, J. Chem. Soc, 2184 (1952).

    Google Scholar 

  346. R. J. Goldacre and I. J. Lorch, Nature 166, 497 (1950), and Internat. Rev. Cytol. 1, 135 (1952).

    Google Scholar 

  347. R. J. Goldacre, A. Loveless, and W. C. J. Ross, Nature 163, 667 (1949).

    Google Scholar 

  348. H. Goldblatt and G. Cameron, J. Exp. Med. 97, 525 (1953).

    Google Scholar 

  349. M. W. Goldblatt, A. F. Henson, and A. R. Sommerville, Biochem. J. 77, 511 (1960).

    Google Scholar 

  350. P. Goldhaber, Proc. Am. Assoc. Cancer Res. 3, 228 (1961).

    Google Scholar 

  351. W. Gordy, in ‘Information Theory in Biology‘, H. P. Yockey, Editor, Pergamon Press, New York, 1958, p. 353.

    Google Scholar 

  352. H. H. Gosch and J. C. Arcos, Nature 190, 272 (1961).

    Google Scholar 

  353. H. H. Gosch, J. C. Arcos and M. F. Argus, submitted for publication.

    Google Scholar 

  354. G. S. Gotterer, T. E. Thompson, and A. L. Lehninger, J. Biophys. Biochem. Cytol. 10, 15 (1961).

    Google Scholar 

  355. A. Graffi, E. Vlamynch, F. Hoffmann, and I. Schulz, Arch. Geschwülstforsch. 5, 110 (1953).

    Google Scholar 

  356. D. E. Green, Perspectives Biol. Med. 2, 163 (1959).

    Google Scholar 

  357. G. E. Green, M. C. Dodd, and A.W. Radike, Proc Soc. Exp. Biol. Med. 90, 517 (1955).

    Google Scholar 

  358. J. P. Greenstein, ‘Biochemistry of Cancer’, 2nd ed., Acad. Press, New York, 1954, pp. 350, 355, 356.

    Google Scholar 

  359. H. H. Greenwood, Brit. J. Cancer 5, 441 (1951).

    Google Scholar 

  360. A. C. Griffin, H. L. Richardson, C. H. Robertson, M. A. O’Neal, and J. D. Spain, J. Natl. Cancer Inst., Suppl. 15, 1623 (1955).

    Google Scholar 

  361. D. Guerritore, Ztschr. Krebsforsch. 61, 649 (1957).

    Google Scholar 

  362. D. Guerritore, Ztschr. Krebsforsch. 61, 655 (1957).

    Google Scholar 

  363. D. N. Gupta, Nature 175, 257 (1955), and J. Path. Bact. 72, 415 (1956).

    Google Scholar 

  364. H. R. Gutmann, U. S. Seal, and C. C. Irving, Cancer Research 20, 1072 (1960).

    Google Scholar 

  365. C. Hackmann, Ztschr. Krebsforsch. 57, 530 (1951).

    Google Scholar 

  366. C. Hackmann, Ztschr. Krebsforsch. 61, 45 (1956).

    Google Scholar 

  367. A. Haddow, Nature 136, 868 (1935).

    Google Scholar 

  368. A. Haddow, Endeavour 2, 27 (1943).

    Google Scholar 

  369. A. Haddow, Brit. Med. Bull. 4, 331 (1946–47).

    Google Scholar 

  370. A. Haddow, Ann. Rev. Biochem. 24, 703 (1955).

    Google Scholar 

  371. A. Haddow, Brit. Med. Bull. 14, 79 (1958).

    Google Scholar 

  372. A. Haddow, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 303.

    Google Scholar 

  373. A. Haddow, in ‘Physiopathology of Cancer’, F. Homburger, Editor, P. B. Hoeber, PubL, New York, 1959, p. 602.

    Google Scholar 

  374. A. Haddow, quoted in J. J. Roberts and G. P. Warwick, Biochem. Pharmacol. 6, 205 (1961).

    Google Scholar 

  375. A. Haddow, R. J. C. Harris, G. A. R. Kon, and E. M. F. Roe, Phil. Trans. Roy. Soc. A 241, 147 (1948).

    Google Scholar 

  376. A. Haddow and E. S. Horning, J. Natl. Cancer Inst. 24, 109 (1960).

    Google Scholar 

  377. A. Haddow and G. A. R. Kon, Brit. Med. Bull. 4, 315 (1946–47).

    Google Scholar 

  378. A. Haddow and A.M.Robinson, Proc. Roy. Soc. B122, 442 (1937); B127, 277 (1939).

    Google Scholar 

  379. A. Haddow and G. M. Timmis, Acta Un. Intern. Cancrum 7, 469 (1951).

    Google Scholar 

  380. H. I. Hadler, V. Darchun, and K. Lee, Science 125, 72 (1957), and J. Natl. Can-cer Inst. 22, 661 (1959).

    Google Scholar 

  381. D. Hadzi, Fuel 32, 112 (1952).

    Google Scholar 

  382. B. Hagihara, T. Nakayama, H. Matsubara, and K. Okunuki, J. Biochem. (Ja-pan) 43, 469 (1956); 44, 595, 601 (1957).

    Google Scholar 

  383. R. Haller, Melliand Textilber. 6, 669 (1925).

    Google Scholar 

  384. R. Haller and A. Nowak, Kolloidchem. Beihefte 13, 83 (1920).

    Google Scholar 

  385. D. L. Hammick and R. B. M. Yule, J. Chem. Soc, 1539 (1940).

    Google Scholar 

  386. K. R. Hanson, J. Kastor, and R. Rendi, Biochim. Biophys. Acta 45, 192 (1960).

    Google Scholar 

  387. J. W. Harman and M. Feigelson, Exp. Cell Res. 3, 509 (1952).

    Google Scholar 

  388. P. N. Harris, Cancer Research 7, 35 (1947).

    Google Scholar 

  389. H. A. Hartmann, E. C. Miller, J. A. Miller, and F. K. Morris, Cancer Research 19, 210 (1959).

    Google Scholar 

  390. J. L. Hartwell, ‘Survey of Compounds Which Have Been Tested for Carcinogenic Activity’, US Public Health Service Publication No. 149, Washington, 1951.

    Google Scholar 

  391. S. Hatem, Compt. Rend. 248, 1056 (1959), and Chimia 13, 158 (1959).

    Google Scholar 

  392. E. Havinga, H. W. Julius, H. Veldstra, and K. C. Winkler, ‘Modern Develop-ment of Chemotherapy’, Elsevier, Amsterdam, 1946, p. 91.

    Google Scholar 

  393. M. Hayano, S. Schiller, and R. I. Dorfman, Endocrinology 46, 387 (1950).

    Google Scholar 

  394. C. Heidelberger, Adv. Cancer Res. 1, 273 (1953).

    Google Scholar 

  395. C. Heidelberger, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 179.

    Google Scholar 

  396. C. Heidelberger and G. R. Davenport, Acta Un. Intern. Cancrum 17, 55 (1961).

    Google Scholar 

  397. C. Heidelberger and M. G. Moldenhauer, Cancer Research 16, 442 (1956).

    Google Scholar 

  398. A. Heller and B. Pullman, Cancer Research 19, 618 (1959).

    Google Scholar 

  399. G. Hems, Nature 181, 1721 (1958).

    Google Scholar 

  400. S. B. Hendricks, J. Phys. Chem. 45, 65 (1941).

    Google Scholar 

  401. J. A. Hendry, R. F. Homer, F. L. Rose, and A. L. Walpole, Brit. J. Pharmacol. 6, 235 (1951).

    Google Scholar 

  402. J. A. Hendry, R. F. Homer, F. L. Rose, and A. L. Walpole, Brit. J. Pharmacol. 6, 357 (1951).

    Google Scholar 

  403. J. A. Hendry, J. J. Matthews, A. L. Walpole, and M. H. C. Williams, Nature 175, 1131 (1955).

    Google Scholar 

  404. A. F. Henson, A. R. Sommerville, M. E. Farquharson, and M. W. Goldblatt, Biochem. J. 58, 383 (1954); 63, 290 (1956).

    Google Scholar 

  405. F. H. Herbstein and G. M. J. Schmidt, J. Chem. Soc., 3302 (1954).

    Google Scholar 

  406. H. Herrmann, Science 132, 529 (1960).

    Google Scholar 

  407. M. L. Hesselbach and H. G. DuBuy, Proc. Soc. Exp. Biol. Med. 83, 62 (1953).

    Google Scholar 

  408. W. E. Heston, J. Natl. Cancer Inst. 11, 415 (1950); 14, 131 (1953).

    Google Scholar 

  409. W. E. Heston and W. D. Levillain, Proc. Soc. Exp. Biol. Med. 82, 457 (1953).

    Google Scholar 

  410. J. Hidalgo and R. W. Whitehead, J. Pharmacol. Exp. Therap. 103, 347 (1951).

    Google Scholar 

  411. C. A. Hiebert, Cancer 12, 663 (1959).

    Google Scholar 

  412. I. Hieger, Am. J. Cancer 39, 496 (1940), Cancer Research 6, 657 (1946), and Brit. Med. Bull. 4, 360 (1947).

    Google Scholar 

  413. I. Hieger, Nature 160, 270 (1947), and Brit. J. Cancer 3, 123 (1949).

    Google Scholar 

  414. I. Hieger, Proc. Roy. Soc. B147, 84 (1957).

    Google Scholar 

  415. I. Hieger, Brit. J. Cancer 13, 439 (1959).

    Google Scholar 

  416. I. Hieger, ‘Carcinogenesis’, Acad. Press, New York, 1961, p. 76.

    Google Scholar 

  417. I. Hieger and S. F. D. Orr, Brit. J. Cancer 8, 274 (1954).

    Google Scholar 

  418. W. T. Hill, D. W. Stanger, A. Pizzo, B. Riegel, P. Shubik, and W. B. Wart-man, Cancer Research 11, 892 (1951).

    Google Scholar 

  419. V. Hirchinson and K. R. Hill, Brit. J. Cancer 14, 637 (1960).

    Google Scholar 

  420. C. H. W. Hirs, J. Am. Chem. Soc. 71, 1893 (1949).

    Google Scholar 

  421. H. H. Hirsch, Ztschr. Krebsforsch. 58, 504 (1952).

    Google Scholar 

  422. C. Hoch-Ligeti, Acta Un. Intern. Cancrum 7, 606 (1951), and Texas Rep. Biol. Med. 10,996 (1952).

    Google Scholar 

  423. C. Hoch-Ligeti, Cancer Research 14, 749 (1954).

    Google Scholar 

  424. C. Hoch-Ligeti, J. Natl. Cancer Inst. 18, 661 (1957).

    Google Scholar 

  425. T. A. Hoffmann and J. Ladik, Cancer Research 21, 474 (1961).

    Google Scholar 

  426. U. Hoffmann, Naturwiss. 32, 260 (1944).

    Google Scholar 

  427. O. Hoffmann-Ostenhof, Science 105, 549 (1947).

    Google Scholar 

  428. K. Hohl, Experientia 3, 109 (1947).

    Google Scholar 

  429. F. Homburger, Am. J. Path. 19, 797 (1943).

    Google Scholar 

  430. E. S. Horning and P. Alexander, 35th Ann. Rep. Brit. Emp. Cancer Campaign, Part II, 1957, p. 64.

    Google Scholar 

  431. E. S. Horning and J. W. Whittick, Brit. J. Cancer 8, 451, 627 (1954).

    Google Scholar 

  432. W. C. Hueper, Public Health Reports, Supplement 209, U. S. Public Health Service, Washington, 1948.

    Google Scholar 

  433. W. C. Hueper, Industr. Med. Surg. 20, 49 (1951).

    Google Scholar 

  434. W. C. Hueper, Industr. Med. Surg. 21, 71 (1952).

    Google Scholar 

  435. W. C. Hueper, Cancer 10, 8 (1957).

    Google Scholar 

  436. C. Huggins, G. Briziarelli and H. Sutton, J. Exp. Med. 100, 25 (1959).

    Google Scholar 

  437. C. Huggins, L. C. Grand and F. P. Brillantes, Proc. Nat. Acad. Sci.45, 1294 (1959).

    Google Scholar 

  438. C. Huggins, E. V. Jensen, and A. S. Cleveland, J. Exp. Med. 100, 225 (1954).

    Google Scholar 

  439. P. E. Hughes, Brit. J. Cancer 13, 751 (1959).

    Google Scholar 

  440. P. E. Hughes, Cancer Research 19, 472 (1959).

    Google Scholar 

  441. T. Hultin, Exp. Cell Res. 10, 71 (1956).

    Google Scholar 

  442. T. Hultin, Exp. Cell Res. 10, 697 (1956).

    Google Scholar 

  443. T. Hultin, Exp. Cell Res. 18, 112 (1959).

    Google Scholar 

  444. T. Hultin, Biochem. Pharmacol. 5, 359 (1961).

    Google Scholar 

  445. T. Hultin, E. Arrhenius, H. Löw, and P. N. Magee, Biochem. J. 76, 109 (1960).

    Google Scholar 

  446. J. V. Hurley and K. N. Ham, Brit. J. Exp. Path. 40, 216 (1959).

    Google Scholar 

  447. J. Iball, Am. J. Cancer 35, 188 (1939).

    Google Scholar 

  448. J. Iball, 34th Ann. Rep. Brit. Emp. Cancer Campaign, p. 493 (1956).

    Google Scholar 

  449. Y. Imai and R. Sato, Biochim. Biophys. Acta 36, 571 (1959); 42, 164 (1960).

    Google Scholar 

  450. D. J. E. Ingram, M. C. R. Symons, and J. G. Tapley, Trans. Faraday Soc. 54, 409 (1958).

    Google Scholar 

  451. H. H. Inhoffen, Progr. Org. Chem. 2, 131 (1953).

    Google Scholar 

  452. H. Inokuchi, S. Shiba, T. Handa, and H. Akamatu, Bull Soc. Chem. Japan 25, 299 (1952).

    Google Scholar 

  453. J. K. Inscoe and J. Axelrod, Federation Proc. 18, 406 (1959).

    Google Scholar 

  454. S. Iversen and N. Arley, Acta Path. Microbiol. Scandinav. 27, 1 (1950).

    Google Scholar 

  455. W. G. Jaffé, Cancer Research 7, 107 (1947).

    Google Scholar 

  456. W. G. Jaffé, Cancer Research 7, 529 (1947).

    Google Scholar 

  457. L. Jedeikin, A. J. Thomas, and S. Weinhouse, Cancer Research 16, 867 (1956).

    Google Scholar 

  458. E. R. H. Jones, quoted in Chem. Eng. News 39, No. 12, 46 (1961).

    Google Scholar 

  459. L. Joseph, Proc. Soc. Exp. Biol. Med. 41, 334 (1939).

    Google Scholar 

  460. J. W. Jull, Brit. J. Cancer 5, 328 (1951).

    Google Scholar 

  461. H. Kacser, Science 124, 151 (1956).

    Google Scholar 

  462. H. S. Kaplan, Cancer Research 19, 791 (1959).

    Google Scholar 

  463. H. S. Kaplan, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 233.

    Google Scholar 

  464. G. Karreman, Bull. Math. Biophysics. 17, 279 (1955).

    Google Scholar 

  465. W. Kauzmann, in ‘Symposium on the Mechanism of Enzyme Action’, W. D. McElroy and B. Glass, Editors, Johns Hopkins Press, Baltimore, 1954, p. 70.

    Google Scholar 

  466. W. Kauzmann and R. G. Douglas, Arch. Biochem. Biophys. 65, 106 (1956).

    Google Scholar 

  467. A. M. Kaye, Cancer Research 20, 44 (1960).

    Google Scholar 

  468. A. M. Kaye, Cancer Research 20, 237 (1960).

    Google Scholar 

  469. C. J. Kensler, Cancer 1, 483 (1948), and J. Biol. Chem. 179, 1079 (1949).

    Google Scholar 

  470. C. J. Kensler, K. Sugiura, N. F. Young, C. R. Halter, and C. P. Rhoads, Science 93, 308 (1941).

    Google Scholar 

  471. R. K. Kielley, Cancer Research 12, 124 (1952).

    Google Scholar 

  472. B. Kihlman, Symbolae Botan. Upsaliensis 11, 3 (1952).

    Google Scholar 

  473. H. H. King, J. L. Hall, A. C. Andrews, and H. L. Cole, J. Pharmacol. Exp. Therap. 40, 275 (1930).

    Google Scholar 

  474. R. Kinosita, Gann 34 165 (1940).

    Google Scholar 

  475. R. Kinosita, Yale J. Biol. Med. 12, 287 (1940).

    Google Scholar 

  476. R. Kinosita and M. Harada, Gann 32, 225 (1938).

    Google Scholar 

  477. A. H. M. Kirby, Cancer Research 7, 333 (1947).

    Google Scholar 

  478. A. H. M. Kirby, Brit. J. Cancer 2, 291 (1948), and Cancer Research 7, 263 (1947).

    Google Scholar 

  479. A. H. M. Kirby and P. R. Peacock, J. Path. Bact. 59, 1 (1947).

    Google Scholar 

  480. A. H. M. Kirby and P. R. Peacock, Glasgow Med. J. 30, 364 (1949).

    Google Scholar 

  481. K. S. Kirby, Biochem. J. 66, 495 (1957).

    Google Scholar 

  482. K. S. Kirby, Brit. J. Cancer 14, 147 (1960).

    Google Scholar 

  483. J. F. Kirsch, P. Siekevitz, and G. E. Palade, J. Biol. Chem. 235, 1419 (1960).

    Google Scholar 

  484. A. Kleczkowski, Brit. J. Exp. Path. 35, 402 (1954).

    Google Scholar 

  485. M. Klein, J. Natl. Cancer Inst. 13, 333 (1952).

    Google Scholar 

  486. M. Klein, Cancer Research 16, 123 (1956).

    Google Scholar 

  487. M. Klein, Cancer Research 19, 1109 (1959).

    Google Scholar 

  488. H. E. Kleinenberg, Arch. des Sci. Biol. (Moscow) 51, (3), 127 (1938).

    Google Scholar 

  489. R. G. Kleinfeld and E. von Haam, Cancer Research 19, 769 (1959).

    Google Scholar 

  490. I. M. Klotz, in ‘Symposium on the Mechanism of Enzyme Action’, W. D. McElroy and B. Glass, Editors, Johns Hopkins Univ. Press, Baltimore, 1954, p. 257.

    Google Scholar 

  491. M. O. Klotz, Am. J. Cancer 35, 38 (1939).

    Google Scholar 

  492. W. E. Knox and A. H. Mehler, Science 113, 237 (1951).

    Google Scholar 

  493. R. E. Kofahl and H. J. Lucas, J. Am. Chem. Soc. 76, 3931 (1954).

    Google Scholar 

  494. P. C. Koller, J. Natl. Cancer Inst. 15, 1237 (1955).

    Google Scholar 

  495. E. C. Kooyman and J. W. Heringa, Nature 170, 661 (1952).

    Google Scholar 

  496. W. Kopaczewski, C. R. Soc. Biol. 118, 1142 (1935).

    Google Scholar 

  497. B. Korpássy, Cancer Research 19, 501 (1959).

    Google Scholar 

  498. B. Korpássy and M. Mosonyi, Brit. J. Cancer 4, 411 (1950).

    Google Scholar 

  499. B. Korpássy, A. Sztanojevits, and M. Koltay, Acta Acad. Sci. Hung. 4, 91 (1954).

    Google Scholar 

  500. P. Kotin, H. L. Falk, W. Lijinsky, and L. Zechmeister, Science 123, 102 (1956).

    Google Scholar 

  501. J. Koutecky and R. Zahradnik, Cancer Research 21, 457 (1960).

    Google Scholar 

  502. H. Kubo, T. Kobayashi, and T. Wada, Med. J. Osaka Univ. 6, 575 (1955).

    Google Scholar 

  503. R. J. Kuchler, M. L. Marlowe, and D. J. Merchant, Exp. Cell Res. 20, 428 (1960).

    Google Scholar 

  504. K. Kusama and H. Terayama, Gann 48, 181 (1957).

    Google Scholar 

  505. K. Kusama, H. Terayama, and K. Teruya, Gann 49, 79, 85, 97, 105 (1958).

    Google Scholar 

  506. A. Lacassagne, Compt. Rend. 195, 630 (1932).

    Google Scholar 

  507. A. Lacassagne, Am. J. Cancer 28, 735 (1936).

    Google Scholar 

  508. A. Lacassagne, ‘Les Cancers Produits par des Substances Chimiques Endogènes‘,Hermann & Co., Paris, 1950.

    Google Scholar 

  509. A. Lacassagne, J. C. Arcos, N. P. Buu-Hoi, and F. Zajdela, Bull. Cancer 44, 545 (1957).

    Google Scholar 

  510. A. Lacassagne, N. P. Buu-Hoi, R. Daudel, and F. Zajdela, Adv. Cancer Res. 4, 316 (1956).

    Google Scholar 

  511. A. Lacassagne, N. P. Buu-Hoi, R. Royer, and G. Rudali, C. R. Soc. Biol. 145, 1451 (1951).

    Google Scholar 

  512. A. Lacassagne, N. P. Buu-Hoi, and F. Zajdela, Compt. Rend. 245, 876 (1957).

    Google Scholar 

  513. A. Lacassagne, N. P. Buu-Hoi, and F. Zajdela, Compt. Rend. 250, 3547 (1960).

    Google Scholar 

  514. A. Lacassagne, N. P. Buu-Hoi, and F. Zajdela, Nature 190, 1007 (1961).

    Google Scholar 

  515. A. Lacassagne, N. P. Buu-Hoi, F. Zajdela, F. Périn, and P. Jacquignon, Nature 191, 1005 (1961).

    Google Scholar 

  516. A. Lacassagne, L. Corre, N. P. Buu-Hoi, and R. Royer, C. R. Soc. Biol. 146, 399 (1952).

    Google Scholar 

  517. A. Lacassagne, F. Zajdela, N. P. Buu-Hoi, and H. Chalvet, Compt. Rend. 244, 273 (1957).

    Google Scholar 

  518. K. J. Laidler, J. Am. Chem. Soc. 72, 2159 (1950).

    Google Scholar 

  519. A. K. Laird and A. D. Barton, Nature 183, 1655 (1959), and 188, 417 (1960).

    Google Scholar 

  520. A. F. Lanham and K. G. A. Pankhurst, Trans. Faraday Soc. 52, 521 (1956).

    Google Scholar 

  521. K. G. Lark, Biochim. Biophys. Acta 45, 121 (1960).

    Google Scholar 

  522. C. D. Larsen, J. Natl. Cancer Inst. 7, 5 (1946–47).

    Google Scholar 

  523. C. D. Larsen, J. Natl. Cancer Inst. 8, 99 (1947–48).

    Google Scholar 

  524. C. D. Larsen, J. Natl. Cancer Inst. 9, 35 (1948–49).

    Google Scholar 

  525. C. D. Larsen, Cancer Research 10, 230 (1950).

    Google Scholar 

  526. R. Latarjet, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 274.

    Google Scholar 

  527. M. Lauffer, J. Am. Chem. Soc. 65, 1793 (1943).

    Google Scholar 

  528. L. W. Law, Cancer Research 1, 397 (1941).

    Google Scholar 

  529. L. W. Law, Proc. Soc. Exp. Biol. Med. 47, 37 (1941).

    Google Scholar 

  530. L. W. Law and M. G. Lewisohn, Cancer Research 1, 695 (1941).

    Google Scholar 

  531. P. D. Lawley, Biochim. Biophys. Acta 26, 450 (1957).

    Google Scholar 

  532. P. D. Lawley, Proc. Chem. Soc, 290 (1957).

    Google Scholar 

  533. P. D. Lawley and C. Wallick, Biochim. Biophys. Acta 26, 450 (1957).

    Google Scholar 

  534. J. O. Laws, Brit. J. Cancer 13, 669 (1959).

    Google Scholar 

  535. A. L. Lehninger, J. Biol. Chem. 234, 2465 (1959).

    Google Scholar 

  536. A. L. Lehninger and B. L. Ray, Biochim. Biophys. Acta 26, 643 (1957).

    Google Scholar 

  537. A. L. Lehninger, B. L. Ray, and M. Schneider, J. Biophys. Biochem. Cytol. 5, 97 (1959).

    Google Scholar 

  538. J. Leiter and M. J. Shear, J. Natl. Cancer Inst. 3, 455 (1943).

    Google Scholar 

  539. B. Lemox, Brit. J. Cancer 9, 631 (1955).

    Google Scholar 

  540. H. Lettré, Ztschr. Physiol. Chem. 280, 28 (1944).

    Google Scholar 

  541. H. Lettré, Naturwiss. 39, 90 (1952).

    Google Scholar 

  542. M. Levine and H. Tarver, J. Biol. Chem. 192, 835 (1951).

    Google Scholar 

  543. G. N. Lewis and M. Calvin, Chem. Revs. 25, 273 (1939).

    Google Scholar 

  544. S. Liao and H. G. Williams-Ashman, Biochem. Pharmacol. 6, 53 (1961).

    Google Scholar 

  545. M. J. A. des Ligneris, Am. J. Cancer 39, 489 (1940).

    Google Scholar 

  546. K. U. Linderström-Lang, ‘Lane Medical Lecture’, Stanford Univ. Press, Stanford 1952.

    Google Scholar 

  547. C. C. Lindgren, Science 124, 26 (1956).

    Google Scholar 

  548. D. Lindsay, Ann. Rep. Brit. Emp. Cancer Campaign 34, 372 (1956).

    Google Scholar 

  549. R. Logan, A. Ficq, and M. Errera, Biochim. Biophys. Acta 31, 402 (1959).

    Google Scholar 

  550. E. Lorenz and H. L. Stewart, J. Natl. Cancer Inst. 1, 273 (1940).

    Google Scholar 

  551. A. Loveless and W. C. J. Ross, Nature 166, 1113 (1950).

    Google Scholar 

  552. H. Lundegårdh, Biochim. Biophys. Acta 27, 653 (1958).

    Google Scholar 

  553. L. M. Lusky and A. A. Nelson, Federation Proc. 16, 318 (1957).

    Google Scholar 

  554. P. N. Magee, Biochem. J. 70, 606 (1958).

    Google Scholar 

  555. P. N. Magee and J. M. Barnes, Brit. J. Cancer 10, 114 (1956).

    Google Scholar 

  556. R. A. Malmgren, B. E. Bennison, and T. W. McKinley, Proc. Soc. Exp. Biol Med. 79, 484 (1952).

    Google Scholar 

  557. L. A. Manson and L. Young, Biochem. J. 47, 170 (1950).

    Google Scholar 

  558. A. H. E. Marshall, Acta path. microbiol. Scandinav. 33, 1 (1953).

    Google Scholar 

  559. E. Mascitelli-Coriandoli, Ztschr. Naturforsch. 14b, 70, 612 (1959).

    Google Scholar 

  560. R. Mason, Brit. J. Cancer 12, 469 (1958).

    Google Scholar 

  561. R. Mason, Nature 181, 820 (1958), and Disc. Faraday Soc. 27, 129 (1960).

    Google Scholar 

  562. N. Mataga, Y. Kaifu, and M. Koizumi, Bull. Chem. Soc. Japan 28, 690 (1955); 29, 465 (1956).

    Google Scholar 

  563. N. Mataga and S. Tsuno, Naturwiss. 44, 304 (1956), and Bull. Chem. Soc. Japan 30, 368 (1957).

    Google Scholar 

  564. C. M. Mauritzen, H. J. Cruft, and E. Stedman, 3rd Intern. Congr. Biochem., Brussels, 1955, Abstract p. 70.

    Google Scholar 

  565. R. L. Mayer, Experientia 6, 241 (1950).

    Google Scholar 

  566. C. J. McCammon, P. Kotin, and H. L. Falk, Proc. Am. Assoc. Cancer Res. 2, 229 (1957).

    Google Scholar 

  567. J. A.W. McCluskie and J. S. F. Niven, J. Path. Bact. 47, 155 (1938).

    Google Scholar 

  568. A. D. McLaren and R. A. Luse, Science 134, 836 (1961).

    Google Scholar 

  569. W. C. McMurray, Canad. J. Biochem. Physiol. 38, 1 (1960).

    Google Scholar 

  570. R. Meier and M. Allgöwer, Experientia 1, 57 (1945).

    Google Scholar 

  571. R. Meier and B. Schär, Experientia 3, 358 (1947).

    Google Scholar 

  572. M. G. Menefee and V. J. Evans, J. Natl. Cancer Inst. 25, 1303 (1960).

    Google Scholar 

  573. E. C. Miller, Cancer Research 11, 100 (1951).

    Google Scholar 

  574. E. C. Miller, J. C. MacDonald and J. A. Miller, Cancer Research 15, 320 (1955).

    Google Scholar 

  575. E. C. Miller and J. A. Miller, Cancer Research 7, 468 (1947).

    Google Scholar 

  576. E. C. Miller and J. A. Miller, Cancer Research 12, 547 (1952).

    Google Scholar 

  577. E. C. Miller and J. A. Miller, J. Natl. Cancer Inst. 15, 1571 (1955).

    Google Scholar 

  578. E. C. Miller and J. A. Miller, Cancer Research 20, 133 (1960).

    Google Scholar 

  579. E. C. Miller, J. A. Miller, and H. A. Hartmann, Cancer Research 21, 815 (1961)

    Google Scholar 

  580. E. C. Miller, J. A. Miller, B. E. Kline, and H. P. Rusch, J. Exp. Med. 88, 89 (1948).

    Google Scholar 

  581. E. C. Miller, J. A. Miller, R. B. Sandin, and R. K. Brown, Cancer Research 9, 504 (1949).

    Google Scholar 

  582. E. C. Miller, J. A. Miller, R. W. Sapp, and G. M. Weber, Cancer Research 9, 336 (1949).

    Google Scholar 

  583. E. C. Miller, R. B. Sandin, J. A. Miller, and H. P. Rusch, Cancer Research 16, 525 (1956).

    Google Scholar 

  584. J. A. Miller, J. C. Arcos, and E. C. Miller, Proc. Am. Assoc. Cancer Res. 2, 34 (1955).

    Google Scholar 

  585. J. A. Miller and C. A. Baumann, Cancer Research 3, 223 (1943).

    Google Scholar 

  586. J. A. Miller and C. A. Baumann, Cancer Research 5, 227 (1945).

    Google Scholar 

  587. J. A. Miller, J. W. Cramer, and E. C. Miller, Cancer Research 20, 950 (1960).

    Google Scholar 

  588. J. A. Miller and E. C. Miller, J. Exp. Med. 87, 139 (1948).

    Google Scholar 

  589. J. A. Miller and E. C. Miller, Adv. Cancer Res. 1, 340 (1953).

    Google Scholar 

  590. J. A. Miller and E. C. Miller, Cancer Research 21, 1068 (1961).

    Google Scholar 

  591. J. A. Miller and E. C. Miller, Proc. 4th Canad. Cancer Conf. 4, 57 (1961).

    Google Scholar 

  592. J. A. Miller, E. C. Miller, and G. C. Finger, Cancer Research 17, 387 (1957).

    Google Scholar 

  593. J. A. Miller, R. B. Sandin, E. C. Miller, and H. P. Rusch, Cancer Research 15, 188 (1955).

    Google Scholar 

  594. J. A. Miller, R. W. Sapp, and E. C. Miller, J. Am. Chem. Soc. 70, 3458 (1948).

    Google Scholar 

  595. J. A. Miller, R. W. Sapp, and E. C. Miller, Cancer Research 9, 652 (1949).

    Google Scholar 

  596. J. S. Mitchell, Proc. Roy. Soc. B126, 241 (1938).

    Google Scholar 

  597. R. Monier, F. Zajdela, P. Chaix, and J. F. Petit, Cancer Research 19, 927 (1959).

    Google Scholar 

  598. M. M. Moodie and C. Reid, Brit. J. Cancer 8, 380 (1954); (B) and C. A. Wallick, Cancer Research 14, 367 (1954).

    Google Scholar 

  599. A. E. Moore, C. M. Southam, and S. S. Sternberg, Science 124, 127 (1956).

    Google Scholar 

  600. H. P. Morris, Adv. Cancer Res. 3, 51 (1955), and in ‘The Thyroid’, Brookhaven Symp. Biol. No. 7, Upton, N.Y., 1955, p. 192.

    Google Scholar 

  601. H. P. Morris, J. Natl. Cancer Inst. 15, 1535 (1955).

    Google Scholar 

  602. H. P. Morris and W. H. Eyestone, J. Natl. Cancer Inst. 13, 1139 (1953).

    Google Scholar 

  603. H. P. Morris, F. E. Ray, K. C. Snell, H. L. Stewart, and B. P. Wagner, ‘Carci-nogenicity of N, N-Fluorenylenebisacetamide’, National Cancer Institute Mono-graph No. 5, Washington, 1961.

    Google Scholar 

  604. H. P. Morris, H. Sidransky, B. P. Wagner, and H. M. Dyer, Cancer Research 20, 1252 (1960).

    Google Scholar 

  605. H. P. Morris, C. A. Velat, and B. P. Wagner, J. Natl. Cancer Inst. 18, 101 (1957).

    Google Scholar 

  606. H. P. Morris, C. A. Velat, B. P. Wagner, M. Dahlgard, and F. E. Ray, J. Natl. Cancer Inst. 24, 149 (1960).

    Google Scholar 

  607. G. C. Mueller, Cancer 10, 716 (1957).

    Google Scholar 

  608. T. Mukherjee, P. De, and S. Mitra, Cancer Research 21, 314 (1961).

    Google Scholar 

  609. A. S. Mulay and C. C. Congdon, J. Natl. Cancer Inst. 14, 571 (1953).

    Google Scholar 

  610. A. S. Mulay and H. I. Firminger, J. Natl. Cancer Inst. 13, 35, 57 (1952).

    Google Scholar 

  611. A. S. Mulay and R. W. O‘Gara, J. Natl. Cancer Inst. 18, 843 (1957).

    Google Scholar 

  612. A. S. Mulay and E. A. Saxén, J. Natl. Cancer Inst. 13, 1259 (1953).

    Google Scholar 

  613. R. S. Mulliken, J. Am. Chem. Soc. 74, 811 (1952), and J. Phys. Chem. 56, 801 (1952).

    Google Scholar 

  614. A. Munck, J. F. Scott, and L. L. Engel, Biochim. Biophys. Acta 26, 397 (1957).

    Google Scholar 

  615. C. Nagata, K. Fukui, and T. Yonezawa, Cancer Research 15, 233 (1955), and J. Chem. Phys. 20, 722 (1952); 22, 1433 (1954).

    Google Scholar 

  616. W. Nakahara, F. Fukuoka, and T. Sugimura, Gann 48, 124 (1957).

    Google Scholar 

  617. W. Nakahara, F. Fukuoka, and S. Sakai, Gann 49, 33 (1958).

    Google Scholar 

  618. W. J. P. Neish, Rec. Trav. Chim. 67, 361 (1948).

    Google Scholar 

  619. A. A. Nelson and G. Woodard, J. Natl. Cancer Inst. 13, 1497 (1953).

    Google Scholar 

  620. A. Nettleship, P. S. Henshaw, and H. L. Meyer, J. Natl. Cancer Inst. 4, 309, 523 (1943).

    Google Scholar 

  621. D. Neubert and I. Hoffmeister, Arch. Exp. Path. Pharmacol. 239, 234 (1960).

    Google Scholar 

  622. M. S. Newman and S. Otsuka, J. Natl. Cancer Inst. 21, 721 (1958).

    Google Scholar 

  623. Y. Nishiyama, Gann 32, 85 (1940).

    Google Scholar 

  624. M. D. Niu, Science 131, 1321 (1960).

    Google Scholar 

  625. M. Nordmann and A. Sorge, Ztschr. Krebsforsch. 51, 168 (1941).

    Google Scholar 

  626. H. Nothdurft, Naturwiss. 42, 75 (1955).

    Google Scholar 

  627. H. Nothdurft, Naturwiss. 42, 106 (1955).

    Google Scholar 

  628. A. Novick and L. Szilard, Cold Spring Harb. Symp. Quant. Biol. 16, 337 (1951).

    Google Scholar 

  629. A. B. Novikoff, Proc. Am. Assoc. Cancer Res. 3, 254 (1961).

    Google Scholar 

  630. O. Nygaard, L. Eldjarn, and K. F. Nakken, Cancer Research 14, 625 (1954).

    Google Scholar 

  631. C. Oberling and C. Rouiller, Ann. Anat. Path. 1, 401 (1956).

    Google Scholar 

  632. V.T. Oliverio and C. Heidelberger, Cancer Research 18, 1094 (1958).

    Google Scholar 

  633. B. S. Oppenheimer, E. T. Oppenheimer, I. Danishefsky, and A. P. Stout, Cancer Research 16, 439 (1956).

    Google Scholar 

  634. B. S. Oppenheimer, E. T. Oppenheimer, I. Danishefsky, A. P. Stout, and F. R. Eirich, Cancer Research 15, 333 (1955).

    Google Scholar 

  635. B. S. Oppenheimer, E. T. Oppenheimer, and A. P. Stout, Proc. Soc. Exp. Biol. Med. 67, 33 (1948), and Trans. Assoc. Am. Physicians, 343 (1948).

    Google Scholar 

  636. B. S. Oppenheimer, E. T. Oppenheimer, and A. P. Stout, Proc. Soc. Exp. Biol. Med. 79, 366 (1952), and Surgical Forum, 672 (1953).

    Google Scholar 

  637. B. S. Oppenheimer , E. T. Oppenheimer, A. P. Stout, and I. Danishefsky, Science 118, 305 (1953).

    Google Scholar 

  638. B. S. Oppenheimer, E. T. Oppenheimer, A. P. Stout, M. Willhite, and I. Dani-shefsky, Cancer 11, 204 (1958).

    Google Scholar 

  639. E. T. Oppenheimer, M. Willhite, I. Danishefsky, and A. P. Stout, Cancer Research 21, 132 (1961).

    Google Scholar 

  640. M. Orchin, J. Org. Chem. 16, 1165 (1951).

    Google Scholar 

  641. J. W. Orr, Brit. J. Cancer 1, 311 (1947).

    Google Scholar 

  642. A. Oth, Biochim. Biophys. Acta 35, 216 (1959).

    Google Scholar 

  643. I. Otsuka, Gann 29, 209 (1947).

    Google Scholar 

  644. I. Otsuka and N. Nagao, Gann 30, 561 (1936).

    Google Scholar 

  645. L. Packer and M. M. Rahman, 5th Ann. Meet., The Biophysical Society, St. Louis, Mo., 1961, Abstract S C5, and L. Packer, personal communication.

    Google Scholar 

  646. L. Packer and A. L. Tappel, J. Biol. Chem. 235, 525 (1960).

    Google Scholar 

  647. C. R. Partanen, Science 131, 926 (1960).

    Google Scholar 

  648. K. E. Paschkiss, Cancer Research 18, 981 (1958).

    Google Scholar 

  649. K. E. Paschkiss, A. Cantarow, and J. Stasney, J. Natl. Cancer Inst. 15, 1525 (1955).

    Google Scholar 

  650. I. M. Peisakovich, G. L. Eingorn, and G. S. Voronjansky, cited in [392], p. 332.

    Google Scholar 

  651. P. Perlman and V. D’Amelio, Nature 181, 491 (1958).

    Google Scholar 

  652. R. A. Peters, Nature 159, 149 (1947).

    Google Scholar 

  653. P. Pfeiffer, Ann. Chem. 412, 253 (1917).

    Google Scholar 

  654. F. S. Philips, Pharmacol. Rev. 2, 281 (1950).

    Google Scholar 

  655. A. PiLERi, L. Ledoux, and H. Poznanska, Rev. Franç. Etudes Clin. Biol. 3, 890 (1958).

    Google Scholar 

  656. L. A. Pinck, Cancer Research 16, 921 (1956).

    Google Scholar 

  657. G. Pincus, Proc. 4th Canad. Cancer Conf. 4, 29 (1961).

    Google Scholar 

  658. H. Plaine and B. Glass, J. Genetics 53, 244 (1955).

    Google Scholar 

  659. S. Popovici and M. Pop, Compt. Rend. 250, 1651 (1960).

    Google Scholar 

  660. H. Popper, J. de la Huerga, and C. Yesinick, Science 118, 80 (1953).

    Google Scholar 

  661. K. R. Porter and C. Bruni, Cancer Research 19, 997 (1959).

    Google Scholar 

  662. V. R. Potter, Federation Proc. 17, 691 (1958).

    Google Scholar 

  663. V. R. Potter, ‘Enzyme Studies on the Deletion Hypothesis of Carcinogenesis’, Bertner Foundation Lecture, Symposium on the ‘Molecular Basis of Neoplasia’, Univ. Texas, Houston, 1961, Abstract p. 14.

    Google Scholar 

  664. V. R. Potter and C. Heidelberger, Physiol. Rev. 30, 487 (1950).

    Google Scholar 

  665. V. R. Potter , H. C. Pitot, T. Ono, and H. P. Morris, Cancer Research 20, 1255 (1960).

    Google Scholar 

  666. A. K. Powell, Brit. J. Cancer 5, 264 (1951).

    Google Scholar 

  667. H. M. Powell, J. Chem. Soc, 61 (1948).

    Google Scholar 

  668. D. M. Prescott, Nature 172, 593 (1953).

    Google Scholar 

  669. B. C. Pressman and H. A. Lardy, Biochim. Biophys. Acta 21, 458 (1956).

    Google Scholar 

  670. R. Preussmann, Arzneimittelforsch. 8, 9, 638 (1958).

    Google Scholar 

  671. J. M. Price, J. W. Harman, E. C. Miller, and J. A. Miller, Cancer Research 12, 192 (1952).

    Google Scholar 

  672. J. M. Price, E. C. Miller, and J. A. Miller, J. Biol. Chem. 173, 345 (1948).

    Google Scholar 

  673. J. M. Price, E. C. Miller, J. A. Miller, and G. M. Weber, Cancer Research 9, 398 (1949); 10, 18 (1950).

    Google Scholar 

  674. J. M. Price, J. A. Miller, and E. C. Miller, Cancer Research 11, 523 (1951).

    Google Scholar 

  675. A. Pullman, in ‘La Mésomérie’ Symposium, L. de Broglie, Editor, Rev. Optique Théor. & Instrument, Suppl., Paris, 1947, p. 101.

    Google Scholar 

  676. A. Pullman, Bull. Soc. Chim. France 21, 595 (1954).

    Google Scholar 

  677. A. Pullman and B. Pullman, Adv. Cancer Res. 3, 117 (1955).

    Google Scholar 

  678. A. Pullman and B. Pullman, ‘La Structure Moléculaire et la Cancérisation par les Substances Chimiques’, Masson, Paris, 1955.

    Google Scholar 

  679. A. Pullman and B. Pullman, Biophys. Biochim. Acta 36, 343 (1959).

    Google Scholar 

  680. B. Pullman and A. Pullman, ‘Les Théories Electroniques de la Chimie Organique’, Masson, Paris, 1952.

    Google Scholar 

  681. B. Pullman and A. Pullman, Proc. Nat. Acad. Sci. 44, 1197 (1958).

    Google Scholar 

  682. B. Pullman and A. Pullman, Rev. Mod. Phys. 32, 428 (1960).

    Google Scholar 

  683. F. W. Putnam, Adv. Protein Chem. 4, 80 (1948).

    Google Scholar 

  684. W. S. Rapson, D. H. Saunder, and E. T. Stewart, J. Chem. Soc, 1110 (1946).

    Google Scholar 

  685. N. Rashevsky, Bull. Math. Biophysics 17, 229 (1955).

    Google Scholar 

  686. R. P. Rastogi, J. A. Miller, and E. C. Miller, Proc. Am, Assoc. Cancer Res. 2, 141 (1956).

    Google Scholar 

  687. L. J. Rather, Bull. Johns Hopkins Hosp. 88, 38 (1951).

    Google Scholar 

  688. F. E. Ray, P. Cambel, M. L. Jung, J. H. Peters, and S. Woislawski, J. Natl. Cancer Inst. 13, 955 (1952).

    Google Scholar 

  689. K. R. Rees and G. F. Rowland, Biochem. J. 78, 89 (1961).

    Google Scholar 

  690. C. Reid, Science 131, 1078 (1960).

    Google Scholar 

  691. E. Reid, Nature 175, 461 (1955).

    Google Scholar 

  692. E. Reid and B. M. Stevens, Biochim. Biophys. Acta 19, 554 (1956), and Biochem. J. 68, 367 (1958).

    Google Scholar 

  693. A. E. Reif, Nature 190, 415 (1961).

    Google Scholar 

  694. B. Reiner and S. Zamenhoff, J. Biol. Chem. 228, 475 (1957).

    Google Scholar 

  695. H. G. Richmond, Scottish Med. J. 2, 169 (1957).

    Google Scholar 

  696. J. J. Roberts and G. P. Warwick, Biochem. Pharmacol. 7, 60 (1958); 6, 205, 217 (1961).

    Google Scholar 

  697. F. J. C. Roe, Nature 175, 636 (1955).

    Google Scholar 

  698. F. J. C. Roe, Brit. J. Cancer 10, 72 (1956).

    Google Scholar 

  699. F. J. C. Roe, Cancer Research 17, 64 (1957).

    Google Scholar 

  700. F. J. C. Roe and O. M. Glendenning, Brit. J. Cancer 10, 357 (1956).

    Google Scholar 

  701. F. J. C. Roe and M. H. Salaman, Brit. J. Cancer 8, 666 (1954).

    Google Scholar 

  702. F. J. C. Roe and M. H. Salaman, Brit. J. Cancer 9, 177 (1955).

    Google Scholar 

  703. I. M. Roitt and W. A. Waters, J. Chem. Soc, 3060 (1949).

    Google Scholar 

  704. L. H. Rombach and I. R. MacGregor, J. Org. Chem. 19, 428 (1954).

    Google Scholar 

  705. P. Rondoni, Adv. Cancer Res. 3, 171 (1955).

    Google Scholar 

  706. F. L. Rose, J. A. Hendry, and A. L. Walpole, Nature 165, 993 (1950).

    Google Scholar 

  707. S. M. Rose, J. Natl. Cancer Inst. 20, 653 (1958).

    Google Scholar 

  708. A. Rosin, Cancer Research 9, 583 (1949).

    Google Scholar 

  709. W. C. J. Ross, Adv. Cancer Res. 1, 397 (1953).

    Google Scholar 

  710. G. Rudali, H. Chalvet, and F. Winternitz, Compt. Rend. 240, 1738 (1955).

    Google Scholar 

  711. H. P. Rusch, D. Bosch, and R. K. Boutwell, Acta Un. Intern. Cancrum 11, 699 (1955).

    Google Scholar 

  712. H. A. Sack, J. recherche Centre Natl. Recherche Sci., Laboratoires de Bellevue, Paris, No. 16, 1 (1951).

    Google Scholar 

  713. H. Sachs, J. Biol. Chem. 228, 23 (1957).

    Google Scholar 

  714. M. H. Salaman, Ann. Rep. Brit. Emp. Cancer Campaign. 33, 162 (1955).

    Google Scholar 

  715. M. H. Salaman and O. M. Glendenning, Brit. J. Cancer 11, 434 (1957).

    Google Scholar 

  716. M. H. Salaman and F. J. C. Roe, Brit. J. Cancer 7, 472 (1953).

    Google Scholar 

  717. M. H. Salaman and F. J. C. Roe, Brit. J. Cancer 10, 363 (1956).

    Google Scholar 

  718. W. D. Salmon, D. H. Copeland, and M. J. Burns, J. Natl. Cancer Inst. 15, 1549 (1955).

    Google Scholar 

  719. D. A. Salzberg, Acta Un. Intern. Cancrum 11, 704 (1955).

    Google Scholar 

  720. A. Samuels, 5th Ann. Meet., The Biophysical Society, St. Louis, Mo., 1961, Abstract TB 9.

    Google Scholar 

  721. R. B. Sandin, R. Melby, A. S. Hay, R. N. Jones, E. C. Miller, and J. A. Miller, J. Am. Chem. Soc. 74, 5073 (1952).

    Google Scholar 

  722. K. K. Sanford, G. D. Likely, and W. R. Earle, J. Natl. Cancer Inst. 15, 215 (1954).

    Google Scholar 

  723. C. Sannié, R. Truhaut, and P. Guérin, Bull. Assoc. franç. Cancer 29, 106 (1941).

    Google Scholar 

  724. C. Sassi and C. Parrucini, Med. Lavoro 45, 93 (1954).

    Google Scholar 

  725. E. Sawicki and F. E. Ray, J. Org. Chem. 19, 1686 (1954).

    Google Scholar 

  726. E. Sawicki and F. E. Ray, J. Org. Chem. 19, 1903 (1954).

    Google Scholar 

  727. L. M. Schabad, C. R. Soc. Biol. 124, 213 (1937), and Acta Un. Intern. Cancrum 3, 189 (1938).

    Google Scholar 

  728. W. Schiller, Am. J. Cancer 31, 486 (1937).

    Google Scholar 

  729. H. R. Schinz, H. Fritz-Niggli, T. W. Campbell, and H. Schmid, Oncologia 8, 233 (1955).

    Google Scholar 

  730. E. Schirm, J. Prakt. Chem. 144, 69 (1935).

    Google Scholar 

  731. D. Schmähl and R. Preussmann, Naturwiss. 46, 175 (1959).

    Google Scholar 

  732. D. Schmähl and R. Preussmann, Naturwiss. 47, 89 (1960).

    Google Scholar 

  733. O. Schmidt , Ztschr. Phys. Chem. B39, 59 (1938).

    Google Scholar 

  734. O. Schmidt, Ztschr. Phys. Chem. B42, 83 (1939).

    Google Scholar 

  735. O. Schmidt, Ztschr. Phys. Chem. B 44, 185, 194 (1939).

    Google Scholar 

  736. O. Schmidt, Naturwiss. 29, 146 (1941).

    Google Scholar 

  737. W. C. Schneider, Cancer Research 6, 685 (1946), and J. Natl. Cancer Inst. 10, 969 (1950).

    Google Scholar 

  738. R. Schoental, Nature 188, 420 (1960).

    Google Scholar 

  739. R. Schoental and M. A. Head, Brit. J. Cancer 9, 457 (1955).

    Google Scholar 

  740. R. Schoental, M. A. Head, and P. R. Peacock, Brit. J. Cancer 8, 458 (1954).

    Google Scholar 

  741. R. Schoental and P. N. Magee, J. Path. Bact. 74, 305 (1957).

    Google Scholar 

  742. H. E. Schroeder and S. N. Boyd, in ‘Molecular Structure and Biological Speci-ficity’, L. Pauling and H. A. Itano, Editors, Amer. Inst. Biol. Sci., Washington, 1957, p. 116.

    Google Scholar 

  743. J. H. Schulman and M. Z. Dogan, Disc. Faraday Soc, No. 16, 158 (1954).

    Google Scholar 

  744. O. Schürch and A.Winterstein, Ztschr. Physiol. Chem. 236, 79 (1935).

    Google Scholar 

  745. W. W. Scott and H. L. Boyd, J. Urol. 70, 914 (1955).

    Google Scholar 

  746. H. Selye, J. Natl. Cancer Inst. 15, 1291 (1955).

    Google Scholar 

  747. A. Sempronj and E. Morelli, Am. J. Cancer 35, 534 (1939).

    Google Scholar 

  748. H. Setälä, Acta Path. Microbiol. Scandinav., Suppl. 115, 1956.

    Google Scholar 

  749. K. Setälä, Nature 174, 873 (1954), and Science 120, 1075 (1954).

    Google Scholar 

  750. K. Setälä, in ‘Berliner Symposium über Fragen der Carcinogenese’, Akademie-Verlag, Berlin, 1960, p.53.

    Google Scholar 

  751. K. Setälä, Acta Un. Intern. Cancrum 17, 32 (1961).

    Google Scholar 

  752. K. Setälä, L. Merenmies, Y. Aho, L. Stjernvall, and O. Ayräpää, Naturwiss. 46, 311 (1959).

    Google Scholar 

  753. K. Setälä, L. Merenmies, L. Stjernvall, and Y. Aho, J. Natl. Cancer Inst. 23, 953 (1959).

    Google Scholar 

  754. K. Setälä, E. E. Niskanen, and M. Nyholm, Naturwiss. 48, 226 (1961).

    Google Scholar 

  755. R. Setlow, Biochim. Biophys. Acta 16, 444 (1955).

    Google Scholar 

  756. M. J. Shear, Am. J. Cancer 28, 334 (1936).

    Google Scholar 

  757. M. J. Shear, Am. J. Cancer 33, 499 (1938).

    Google Scholar 

  758. M. J. Shear and J. Leiter, J. Natl. Cancer Inst. 2, 99 (1941).

    Google Scholar 

  759. M. J. Shear and J. Leiter, J. Natl. Cancer Inst. 2, 241 (1941).

    Google Scholar 

  760. K. Shikama and I. Yamazaki, Nature 190, 83 (1961).

    Google Scholar 

  761. M. B. Shimkin, Cancer 7, 410 (1954).

    Google Scholar 

  762. P. Shubik and J. L. Hartwell, ‘Survey of Compounds Which Have Been Tested for Carcinogenic Activity’. Supplement I, U.S. Public Health Service Publication No. 149, Washington, 1957.

    Google Scholar 

  763. G. Siebert, Experientia 14, 449 (1958).

    Google Scholar 

  764. P. Siekevitz, Exp. Cell Res., Suppl. 7, 90 (1959).

    Google Scholar 

  765. P. Siekevitz, in ‘Regulation of Cell Metabolism’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 17.

    Google Scholar 

  766. P. Siekevitz and V. R. Potter, Cancer Research 13, 513 (1953).

    Google Scholar 

  767. M. V. Simpson, E. FArber, and H. Tarver, J. Biol. Chem. 182, 81 (1950).

    Google Scholar 

  768. J. C. Skou, Biochim. Biophys. Acta 31, 1 (1959).

    Google Scholar 

  769. A. R. Sommerville and C. Heidelberger, Cancer Research 21, 581 (1961).

    Google Scholar 

  770. S. Sorof and P. P. Cohen, Cancer Research 11, 376 (1951).

    Google Scholar 

  771. S. Sorof, P. P. Cohen, E. C. Miller, and J. A. Miller, Cancer Research 11, 383 (1951).

    Google Scholar 

  772. S. Sorof, E. M. Young, and P. L. Fetterman, Exp. Cell Res. 20, 253 (I960).

    Google Scholar 

  773. S. Sorof, E. M. Young, and M. G. Ott, Cancer Research 18, 33 (1958).

    Google Scholar 

  774. S. Spitz, W. H. Maguigan, and K. Dobriner, Cancer 3, 789 (1950).

    Google Scholar 

  775. S. Stamer, Acta Path. Microbiol. Scandinav., Suppl. 47, 158 (1943).

    Google Scholar 

  776. S. Stamer and J. Engelbreth-Holm, Acta Path. Microbiol. Scandinav. 20, 360 (1943).

    Google Scholar 

  777. P. E. Steiner, Cancer Research 3, 385 (1943).

    Google Scholar 

  778. P. E. Steiner and J. H. Edgecomb, Cancer Research 12, 657 (1952).

    Google Scholar 

  779. P. E. Steiner and H. J. Falk, Cancer Research 11, 56 (1951).

    Google Scholar 

  780. J. Steinhardt, C. H. Fugitt, and M. J. Harris, J. Res. Natl. Bureau Standards 26, 293 (1941).

    Google Scholar 

  781. J. A. Stekol, U. Mody, and J. Perry, J. Biol. Chem. 235, PC 59, (1960).

    Google Scholar 

  782. H. L. Stewart, K. C. Snell and W.V. Hare, J. Natl. Cancer Inst. 21, 999 (1958).

    Google Scholar 

  783. H. F. Stich, J. Natl. Cancer Inst. 24, 1238 (1960).

    Google Scholar 

  784. N. E. Stinson, Nature 188, 678 (1960).

    Google Scholar 

  785. M. J. Striebich, E. Shelton, and W. C. Schneider, Cancer Research 13, 279 (1953).

    Google Scholar 

  786. L. C. Strong, Brit. J. Cancer 3, 97 (1949).

    Google Scholar 

  787. E. Stubblefield and G. C. Mueller, Cancer Research 20, 1646 (1960).

    Google Scholar 

  788. J.M. Sturtevant, S.A.Rice, and P. Geiduschek, Disc. Faraday Soc. 25,138 (1958).

    Google Scholar 

  789. M. Sullivan and K. Blanchard, Bull. Johns Hopkins Hosp. 81, 65 (1947).

    Google Scholar 

  790. N. Svartholm, Arkiv. Kemi. Min. Geol. A 15, No. 13 (1941).

    Google Scholar 

  791. W. Szybalski, 15th Ann. Symp. on Fundamental Cancer Res., ‘The Molecular Basis of Neoplasia’, Houston, 1961, Abstract p. 9.

    Google Scholar 

  792. N. Takizawa, Proc. Imper. Acad. Japan 16, 309 (1940).

    Google Scholar 

  793. N. Takizawa, Gann 34, 1, 158 (1940); 35, 327 (1941).

    Google Scholar 

  794. A. Tannenbaum, Acta Un. Intern. Cancrum 17, 72 (1961).

    Google Scholar 

  795. H. Tarver, in ‘Amino Acids and Proteins’, D. M. Greenberg, Editor, C. C. Thomas, Springfield, 1951, p. 769.

    Google Scholar 

  796. H. Terayama and M. Otsuka, Gann 51, 113 (1960).

    Google Scholar 

  797. R. Thomas, Biochim. Biophys. Acta 14, 131 (1954).

    Google Scholar 

  798. H.Tiedemann, Ztschr. Naturforsch. 8b, 49 (1953).

    Google Scholar 

  799. G. M. Timmis, 12th Intern. Congr. Pure and Appl. Chem., 1951, Abstract p. 334.

    Google Scholar 

  800. G. M. Timmis, Biochem. Pharmacol. 4, 49 (1960).

    Google Scholar 

  801. Y. Tokoro, Gann 34, 149 (1940).

    Google Scholar 

  802. E. G. Trams, V. N. Mareshwar, and P. K. Smith, Cancer Research 21, 560 (1961).

    Google Scholar 

  803. E. G. Trams, M. W. Nadkarni, V. DeQuattro, M. Davies, and P. K. Smith, Bio-chem. Pharmacol. 2, 7 (1959).

    Google Scholar 

  804. W. Troll and N. Nelson, J. Am. Industr. Hyg. Assoc. 19, 499 (1958).

    Google Scholar 

  805. R. Truhaut, ‘Les facteurs chimiques de cancérisation. Le problème des substances cancérigènes endogènes’, Soc. Edition Enseignement Supérieur, Paris, 1947, p. 95; and Thérapie 5, 199 (1950).

    Google Scholar 

  806. F. C. Turner, J. Natl. Cancer Inst. 2, 81 (1941).

    Google Scholar 

  807. A. R. Ubbelohde and F. A. Lewis, ‘Graphite and Its Crystal Compounds’, Cla-rendon Press, Oxford, 1960, p. 110.

    Google Scholar 

  808. M. Umeda, Gann 47, 51 (1956).

    Google Scholar 

  809. K. ViCKERMAN, Nature 188, 248 (1960).

    Google Scholar 

  810. A. Vladimirov and S. V. Konev, Biophysics (Pergamon transi.) 2, 1 (1957).

    Google Scholar 

  811. H. J. Vogel, Proc. Natl. Acad. Sci. 43, 491 (1957).

    Google Scholar 

  812. G. S. Voronjansky, T. A. PiSAREVA and J. E. Sorin, Arch. des Sci. Biol. (Moscow) 55, (2), 89 (1939).

    Google Scholar 

  813. A. L. Walpole, Ann. N. Y. Acad. Sci. 68, 750 (1958).

    Google Scholar 

  814. A. L. Walpole, D. C. Roberts, F. L. Rose, J. A. Hendry, and R. F. Homer, Brit. J. Pharmacol. 9, 306 (1954).

    Google Scholar 

  815. A. L. Walpole, M. H. C. Williams, and D. C. Roberts, Brit. J. industr. Med. 9, 255 (1952).

    Google Scholar 

  816. A. L. Walpole, M. H. C. Williams, and D. C. Roberts, Brit. J. industr. Med. 11, 105 (1954).

    Google Scholar 

  817. A. L. Walpole, M. H. C.Williams and D. C. Roberts, Brit. J. Cancer 9, 170 (1955).

    Google Scholar 

  818. A. L. Walpole, M. H. C. Williams, D. C. Roberts, and J. A. Hendry, Acta Un.Intern. Cancrum 10, 174 (1954)

    Google Scholar 

  819. S. S. Waravdekar and K. J. Ranadive, J. Natl. Cancer Inst. 18, 555 (1957).

    Google Scholar 

  820. S. S. Waravdekar and K. J. Ranadive, J. Natl. Cancer Inst. 21, 1151 (1958).

    Google Scholar 

  821. D. N. Ward and J. D. Spain, Cancer Research 17, 623 (1957).

    Google Scholar 

  822. F. L. Warren, Biochem. J. 37, 338 (1943).

    Google Scholar 

  823. G. Weber, Biochem. J. 75, 345 (1960).

    Google Scholar 

  824. G. Weber, G. Banerjee, and H. P. Morris, Cancer Research 21, 933 (1961).

    Google Scholar 

  825. G. Weber and A. Cantero, Cancer Research 17, 995 (1957).

    Google Scholar 

  826. H. W. Wedler, Deutsch. Med. Wschr. 69, 575 (1943).

    Google Scholar 

  827. C. S. Weil, H. F. Smyth, and T. W. Nale, Arch. Industr. Hyg. 5, 535 (1952).

    Google Scholar 

  828. E. Weiler, Strahlentherapie 93, 213 (1954).

    Google Scholar 

  829. E. Weiler, Ztschr. Naturforsch. 7b, 324 (1952); 11b, 32 (1956).

    Google Scholar 

  830. E. Weiler, Brit. J. Cancer 10, 553, 560 (1956).

    Google Scholar 

  831. E. Weiler, in ‘Carcinogenesis. Mechanisms of Action’, Ciba Foundation Symp., Little, Brown and Co., Boston, 1959, p. 165.

    Google Scholar 

  832. H. Weil-Malherbe, Biochem. J. 40, 351, 363 (1946).

    Google Scholar 

  833. H. Weil-Malherbe and F. Dickens, Cancer Research 6, 171 (1946).

    Google Scholar 

  834. S. Weinhouse, Adv. Cancer Res. 3, 269 (1955).

    Google Scholar 

  835. S. Weinhouse, Science 124, 267 (1956).

    Google Scholar 

  836. E. K. Weisburger and J. H. Weisburger, Adv. Cancer Res. 5, 331 (1958).

    Google Scholar 

  837. J. H. Weisburger, Biochim. Biophys. Acta 16, 382 (1955).

    Google Scholar 

  838. J. H. Weisburger, P. H. Grantham, H. P. Morris, and E. K. Weisburger, J. Natl. Cancer Inst. 27, 153 (1961).

    Google Scholar 

  839. J. H. Weisburger, E. K. Weisburger, H. P. Morris, and H. A. Sober, Cancer Research 12, 305 (1952).

    Google Scholar 

  840. J. Weiss, J. Chem. Soc, 245 (1942).

    Google Scholar 

  841. J. Weiss, J. Chem. Soc, 462 (1943).

    Google Scholar 

  842. P. Weiss, Science 115, 487 (1952), and J. Gen Physiol. 41, 1 (1957).

    Google Scholar 

  843. P. Weiss, in ‘Biophysical Science — A Study Program’, J. L. Oncley, Editor, John Wiley, New York, 1959, p. 11.

    Google Scholar 

  844. C. E. Wenner and S. Weinhouse, Cancer Research 13, 21 (1953).

    Google Scholar 

  845. J. Whetstone, Disc. Faraday Soc, No. 16, 132 (1954), and J. Chem. Soc, 4841 (1956).

    Google Scholar 

  846. F. R. White and A. B. Eschenbrenner, J. Natl. Cancer Inst. 6, 19 (1945).

    Google Scholar 

  847. J. M. Whittcutt , D. A. Sutton, and J. R. Nunn, Biochem. J. 75, 557 (1960).

    Google Scholar 

  848. F. H. Wiley, J. Biol. Chem. 124, 627 (1938).

    Google Scholar 

  849. R. Willheim and A. C. Ivy, Gastroenterology 23, 1 (1953).

    Google Scholar 

  850. M. L. Williams, Biochim. Biophys. Acta 47, 411 (1961).

    Google Scholar 

  851. R. T. Williams, ‘Detoxication Mechanisms’, John Wiley, New York, 1959, p. 245.

    Google Scholar 

  852. J. D. Wilson, K. D. Gibson, and S. Udenfriend, J. Biol. Chem. 235, 3213 (1960).

    Google Scholar 

  853. G. H. Wirtz and J. C. Arcos, Experientia 14, 177 (1958).

    Google Scholar 

  854. O. Wiss and H. Hellman, Ztschr. Naturforsch. 8b, 70 (1953).

    Google Scholar 

  855. D. L. Woernley, Arch. Biochem. Biophys. 50, 199 (1954).

    Google Scholar 

  856. G. Wolf, ‘Chemical Induction of Cancer’, Harvard Univ. Press, Cambridge, Mass., 1952, p. 28.

    Google Scholar 

  857. S. Wolff and H. E. Luippold, Science 122, 231 (1955), and in ‘Progress in Radio-logy’, Oliver and Boyd, Edinburgh, 1956, p. 217.

    Google Scholar 

  858. G. E. W. Wolstenholme and C. M. O’Connor, Editors, ‘Regulation of Cell Meta-bolism’, Ciba Foundation Symp., Little, Brown and Co., 1959.

    Google Scholar 

  859. T. W. Wong, D. S. Juras, and R. W. Wissler, J. Natl. Cancer Inst. 22, 363 (1959).

    Google Scholar 

  860. D. L. Woodhouse, Brit. J. Cancer 8, 346 (1954); 9, 418 (1955).

    Google Scholar 

  861. M. Woods, H. G. DuBuy, and D. Burk, Zoologica 35, 30 (1950).

    Google Scholar 

  862. M. Woods, J.; Hunter, and D. Burk, J. Natl. Cancer Inst. 16, 351 (1955).

    Google Scholar 

  863. S. Wright, Am. Naturalist 90, 5 (1956).

    Google Scholar 

  864. R. Wurmser, Compt. Rend. 244, 3533 (1958).

    Google Scholar 

  865. C. S. Wyatt, J. A. Miller, and E. C. Miller, Proc. Am. Assoc. Cancer Res. 3, 279 (1961).

    Google Scholar 

  866. E. L. Wynder and D. Hoffmann, Cancer 12, 1194 (1959).

    Google Scholar 

  867. J. Yamazaki and S. Sato, J. Dermat. Urol. 42, 332 (1937).

    Google Scholar 

  868. N. C. Yang, A. J. Castro, M. Lewis, and T. W. Wong, Science 134, 386 (1961).

    Google Scholar 

  869. F. G. Zac, J. H. Holzner, E. J. Singer, and H. Popper, Cancer Research 20, 96 (1960).

    Google Scholar 

  870. T. Zsolnai, Biochem. Pharmacol. 5, 1 (1960).

    Google Scholar 

  871. G. Zubay, personal communication.

    Google Scholar 

  872. G. Zubay, 15th Ann. Symp. on Fundamental Cancer Res., ‘The Molecular Basis of Neoplasia’, Houston, 1961, Abstract p. 9.

    Google Scholar 

  873. G. Zubay and P. Doty, Biochim. Biophys. Acta 29, 47 (1958).

    Google Scholar 

  874. S. Zylberszac, C. R. Soc. Biol. 145, 136 (1951).

    Google Scholar 

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Authors and Affiliations

  1. The Research Laboratory, US Public Health Service Hospital, 210 State Street, New Orleans, Louisiana, USA

    Joseph C. Arcos

  2. Departments of Medicine and Biochemistry, Tulane University Medical School, New Orleans, Louisiana, USA

    Joseph C. Arcos

  3. Gastrointestinal Research Laboratory, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA

    Martha Arcos

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  1. Joseph C. Arcos
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  1. Basel, Germany

    Ernst Jucker

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Ce chapitre est dédié à la mémoire de Pierre Barbieri.

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Arcos, J.C., Arcos, M. (1962). Molecular Geometry and Mechanisms of Action of Chemical Carcinogens. In: Jucker, E. (eds) Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques. Progress in Drug Research, vol 4. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7044-3_5

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