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Angiogenesis pp 272–276Cite as

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Liver or lung colonization by F9 teratocarcinoma cells follows specific interactions with the target organ

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Part of the book series: Experientia Supplementum ((EXS,volume 61))

Abstract

It is widely accepted today that, in many instances, cancer metastases do not occur at random, and specific organs represent the preferential target of given tumors. According to the two main theories that have been proposed to explain the organ distribution pattern of metastases, either the vascular connections of the primary tumor [1] and/or specific interactions between the malignant cells and the target organ [2] will decide the localization of metastatic colonies.

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References

  1. Ewing J: A treatise on tumors. 3rd edition, 1928, W.B. Saunders, Philadelphia.

    Google Scholar 

  2. Paget S: Distribution of secondary growths in cancer of the breast. Lancet 1889; 1: 571–573.

    Article  Google Scholar 

  3. Strickland S, Mandavi V: The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell 1978; 15; 393–403.

    Article  Google Scholar 

  4. Terrana B, Rusciano D, Pacenti L: Organ colonization pattern of retinoic acid treated and untreated mouse embryonal carcinoma F9 cells. Cancer Res 1987; 47: 3791–3797.

    Google Scholar 

  5. Rusciano D, Lorenzoni P, Burger MM: The role of both specific cellular adhesion and growth promotion in liver colonization by F9 embryonal carcinoma cells. Int J Cancer 1991; 48, in press.

    Google Scholar 

  6. Gillies RJ, Didier N, Denton M: Determination of cell number in monolayer cultures. Analyt Biochem 1986; 159: 109–113.

    Article  Google Scholar 

  7. Liotta LA, Nageswara Rao C, Wewer UM: Biochemical interactions of tumor cells with the basement membrane. Ann Rev Biochem 1986; 55: 1037–1057.

    Article  Google Scholar 

  8. Doerr R, Zvibel I, Chiuten D, D’Olimpio J, Reid LM: Clonal growth of tumors on tissue-specific biomatrices and correlation with organ site specificity of metastasis. Cancer Res 1989; 49: 384–392.

    Google Scholar 

  9. Burger MM and Madnick HM: General and liver specific metastasis: Possible mechanisms, in Bianchi L, Gerok W, Landmann L, Sickinger K, Stalder GA (eds); Liver in metabolic diseases (Proceedings of the 35`h Falk Symposium). MTP Press Ltd. 1983; pp 351–365.

    Google Scholar 

  10. Sargent NSE, Oestreicher M, Haidvogl H, Madnick HM, Burger MM: Growth regulation of cancer metastases by their host organ. Proc Natl Acad Sci (Wash) 1988; 85: 7251–7255.

    Article  Google Scholar 

  11. Leoncini L, Pacenti L, Rusciano. D, Burroni D, Garbisa S, Cintorino M, Terrana B: Correlation between differentiation and lung colonization by retinoic acid treated F9 cells as revealed by the expression pattern of extracellular matrix and cell surface antigens. Amer J Pathol 1988; 130: 505–514.

    Google Scholar 

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Rusciano, D., Lorenzoni, P., Burger, M.M. (1992). Liver or lung colonization by F9 teratocarcinoma cells follows specific interactions with the target organ. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_43

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  • DOI: https://doi.org/10.1007/978-3-0348-7001-6_43

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7003-0

  • Online ISBN: 978-3-0348-7001-6

  • eBook Packages: Springer Book Archive

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