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Angiogenin and endothelial cells

  • Chapter
Angiogenesis

Part of the book series: Experientia Supplementum ((EXS,volume 61))

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Abstract

Antiogenin is a potent blood vessel-inducing polypeptide that has a unique ribonucleolytic activity. Initially identified from tumor cells conditioned medium through its ability to induce neovascularization in the chick embryo chorioallantoic membrane assay [1], angiogenin has also been purified from normal plasma [2] which suggested that it might be involved in endothelium homeostasis. Angiogenin is highly homologous to pancreatic ribonuclease A with 68% amino acid sequence homology and conserved essential active site residues [3]. However, angiogenin is inactive in standard ribonuclease assays but has a ribonucleolytic specificity toward ribosomal and transfer RNAs [4]. This enzymic activity might be relevant to the process of angiogenesis since a functional active site seems necessary for the expression of its angiogenic property [5]; however, it appears not to be sufficient [6].

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Author information

Authors and Affiliations

  1. Laboratoire de Biotechnologie des Cellules Eucaryotes, Université Paris, Val de Marne, Créteil, France

    Josette Badet, Fabrice Soncin & Denis Barritault

Authors
  1. Josette Badet
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  2. Fabrice Soncin
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  3. Denis Barritault
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Editor information

Editors and Affiliations

  1. Research Division, Dept. of Surgery, University Hospital Zurich, 8091, Zurich, Switzerland

    Rudolf Steiner

  2. Dept. of Chemical and Bioengineering, University of Pennsylvania, Room 312, Towne Building/D3, 19104, Philadelphia, PA, USA

    Paul B. Weisz

  3. Dept. of Chemical Engineering and Harvard — MIT Division of Health, Science and Technology, Massachusetts Institute of Technology, Building E 25 Room 342, 02139, Cambridge, MA, USA

    Robert Langer

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Badet, J., Soncin, F., Barritault, D. (1992). Angiogenin and endothelial cells. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_36

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  • DOI: https://doi.org/10.1007/978-3-0348-7001-6_36

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7003-0

  • Online ISBN: 978-3-0348-7001-6

  • eBook Packages: Springer Book Archive

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