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Thrombospondin modulates basic fibroblast growth factor activities on endothelial cells

  • Chapter
Angiogenesis

Part of the book series: Experientia Supplementum ((EXS,volume 61))

Abstract

We previously reported that thrombospondin (TSP) induces endothelial cell (EC) adhesion, spreading and motility, suggesting that it can play a role in angiogenesis. We then studied whether TSP might modulate EC response to known angiogenic stimuli in vitro. Here we describe that TSP inhibits EC chemotactic response to basic fibroblast growth factor (bFGF). Furthermore, TSP and its 140 kD fragment reduce EC proliferative response to serum and bFGF. These data support the indicated role of TSP and its 140 kD fragment in angiogenesis and in related pathologies including tumor malignancy.

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Author information

Authors and Affiliations

  1. Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy

    Giulia Taraboletti, Dorina Belotti & Raffaella Giavazzi

Authors
  1. Giulia Taraboletti
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  2. Dorina Belotti
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  3. Raffaella Giavazzi
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Editor information

Editors and Affiliations

  1. Research Division, Dept. of Surgery, University Hospital Zurich, 8091, Zurich, Switzerland

    Rudolf Steiner

  2. Dept. of Chemical and Bioengineering, University of Pennsylvania, Room 312, Towne Building/D3, 19104, Philadelphia, PA, USA

    Paul B. Weisz

  3. Dept. of Chemical Engineering and Harvard — MIT Division of Health, Science and Technology, Massachusetts Institute of Technology, Building E 25 Room 342, 02139, Cambridge, MA, USA

    Robert Langer

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Taraboletti, G., Belotti, D., Giavazzi, R. (1992). Thrombospondin modulates basic fibroblast growth factor activities on endothelial cells. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_32

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  • DOI: https://doi.org/10.1007/978-3-0348-7001-6_32

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7003-0

  • Online ISBN: 978-3-0348-7001-6

  • eBook Packages: Springer Book Archive

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