Abstract
Metalloproteinases are a multigene family of metal-dependent enzymes (usually CA+2 or Zn+2) whose activity is considered to be the key rate-limiting step in extracellular matrix degradation. Of the enzyme systems whose activity and control could have significant physiological ramifications, the metalloproteinase family has, in recent years, been shown to play a prominent role in the regulation of such phenomena as neovascularization, tumor growth and metastasis. An accumulating body of evidence has suggested that the control of metalloproteinases, specifically by their endogenous inhibitors, might provide an important strategy for the control of such phenomenon.
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References
Matrisian L: Metalloproteinases and their inhibitors in matrix remodelling. Trends Genet 1990; 6: 121–125.
Librach CL, Werb Z, Fitzerald ML, Chiu K, Corwin NM, Esteves RA, Grobelny D, Galardy R, Damsky C, Fisher SJ: 92-kD Type IV collagenase mediates invasion of human cytotrophoblasts. J Cell Biol 1991; 113: 437–449.
Brem H, Folkman J: Inhibition of tumor angiogenesis mediated by cartilage. J Expt Med 1975; 141: 427–439.
Eisenstein R, Kuettner KE, Neopolitan C, Soble L, Sorgente N: The resistance of certain tissues to invasion. III. Cartilage extracts inhibit the growth of fibroblasts and endothelial cells in culture. Am J Pathol 1975; 81: 337–348.
Sorgente N, Kuettner KE, Soble L, Eisenstein R: The resistance of certain tissues to invasion. II. Evidence for extractable factors in cartilage which inhibit invasion by vascularized mesenchyme. Am J Pathol 1975; 32: 217–222.
Shirai E: Production of an anti-angiogenesis factor by cultured chondrocytes and establishment of a cell line which produces the factor. J Osaka Univ Dent Soc 1987; 32: 163–180.
Langer R, Brem H, Falterman K, Klein M, Folkman J: Isolation of a cartilage factor that inhibits tumor neovascularization. Science 1976; 193: 70–72.
Langer R, Conn H, Vacanti J, Haudenschild C, Folkman J: Control of tumor growth in animals by infusion of an angiogenesis inhibitor. Proc Natl Acad Sci USA 1980; 7: 4331–4335.
Moses MA, Sudhalter J, Langer R: Identification of an inhibitor of neovascularization from cartilage. Science 1990; 248: 1408–1410.
Ausprunk D, Folkman J: Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 1977; 14: 53–65.
Connolly DJ, Knight MB, Harakas NK, Wittwer AJ, Feder J: Determination of the number of endothelial cells in culture using an acid phosphatase assay. Anal Biochem 1986; 152: 136–140.
Langer R, Moses MA: Biocompatible controlled release polymers for delivery of polypeptides and growth factors. J Cell Biochem 1991; 45: 340–345.
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© 1992 Birkhäuser Verlag Basel/Switzerland
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Moses, M.A., Langer, R. (1992). Metalloproteinase inhibition as a mechanism for the inhibition of angiogenesis. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_23
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DOI: https://doi.org/10.1007/978-3-0348-7001-6_23
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7003-0
Online ISBN: 978-3-0348-7001-6
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