Abstract
Angiogenesis plays a critical role in a number of physiological and pathological settings, including wound healing, diabetic retinopathy, and tumor growth [1]. Until recently however, angiogenesis could only be studied in animal models, with the attendant drawbacks of not being able to precisely define the molecular components of this process in vivo. In an attempt to better understand the regulatory mechanisms of angiogenesis, we set out to develop novel experimental systems, in which essential components of the neovascularization process can be recapitulated and subsequently modulated and analyzed under well-defined in vitro conditions. In order to approximate as closely as possible the in vivo situation, we have designed three-dimensional culture systems allowing the re-establishment of the normal interactions between microvascular endothelial cells and the surrounding extracellular matrix.
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© 1992 Birkhäuser Verlag Basel/Switzerland
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Montesano, R., Pepper, M.S., Vassalli, JD., Orci, L. (1992). Modulation of angiogenesis in vitro. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_21
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DOI: https://doi.org/10.1007/978-3-0348-7001-6_21
Publisher Name: Birkhäuser, Basel
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Online ISBN: 978-3-0348-7001-6
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