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Five FGF receptors with distinct expression patterns

  • Chapter
Angiogenesis

Part of the book series: Experientia Supplementum ((EXS,volume 61))

Abstract

The fibroblast growth factors (FGF) constitute a polypeptide family whose members can interact with cell surface receptors to modulate gene expression for cell proliferation and differentiation. Seven struc­turally related heparin binding FGFs are known. The first discovered members of the family were aFGF and bFGF, also called HBGF-1/ ECGF (heparin binding growth factor/endothelial cell growth factor) and HBGF-2, respectively. The tertiary fold of bFGF is similar to that of interleukin-1 [1–3]. Amino acid sequence analysis demonstrates 55% identity between aFGF and bFGF. Sequence homology and similar biological responses suggest that they are derived from a common ancestral gene. Both aFGF and bFGF also lack an N-terminal signal peptide sequence (Fig. 1) and thus their mechanism of secretion is unknown.

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Author information

Authors and Affiliations

  1. Cancer Biology Laboratory, Departments of Virology and Pathology, University of Helsinki, 00290, Helsinki, Finland

    Jaana Korhonen, Juha Partanen, Elina Eerola, Satu Vainikka, Riitta Alitalo, Tomi P. Mäkelä & Kari Alitalo

  2. Department of Medical Biochemistry, University of Turku, 20520, Turku, Finland

    Minna Sandberg & Harri Hirvonen

Authors
  1. Jaana Korhonen
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  2. Juha Partanen
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  3. Elina Eerola
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  4. Satu Vainikka
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  5. Riitta Alitalo
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  6. Tomi P. Mäkelä
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  7. Minna Sandberg
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  8. Harri Hirvonen
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  9. Kari Alitalo
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Editor information

Editors and Affiliations

  1. Research Division, Dept. of Surgery, University Hospital Zurich, 8091, Zurich, Switzerland

    Rudolf Steiner

  2. Dept. of Chemical and Bioengineering, University of Pennsylvania, Room 312, Towne Building/D3, 19104, Philadelphia, PA, USA

    Paul B. Weisz

  3. Dept. of Chemical Engineering and Harvard — MIT Division of Health, Science and Technology, Massachusetts Institute of Technology, Building E 25 Room 342, 02139, Cambridge, MA, USA

    Robert Langer

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Korhonen, J. et al. (1992). Five FGF receptors with distinct expression patterns. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_16

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  • DOI: https://doi.org/10.1007/978-3-0348-7001-6_16

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7003-0

  • Online ISBN: 978-3-0348-7001-6

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