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Tumor angiogenesis: evidence of new blood channels from plasma infiltrations

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Part of the book series: Experientia Supplementum ((EXS,volume 61))

Abstract

Stroma formation in Ehrlich carcinoma, studied with histochemical and TEM techniques, is similar to wound healing. In this tumour mast cells, macrophages, adipocytes, platelets and fibrin seem to co-operate locally with malignant cells in regulating stroma formation. The gaps opened in the tumor parenchyma by plasma outpouring from local blood vessels seem to offer easy routes for endothelial cell migration towards ill-nourished areas, and may explain the irregular aspect of tumor microvascularity.

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References

  1. Zipori D: Stromal cells in tumor growth and regression. Cancer J 1990; 3: 164–169.

    Google Scholar 

  2. Nagy JA, Brown LF, Senger DR, Lanir N, Van De Water L, Dvorak AM, Dvorak HF: Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta 1988; 948: 305–326.

    Google Scholar 

  3. Blood CH, Zetter BR: Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta 1990; 1032: 89–118.

    Google Scholar 

  4. Freitas I, Pontiggia P, Barni S, Bertone V, Parente M, Novarina A, Roveta G, Gerzeli G, Stoward PJ: Histochemical probes for the detection of hypoxic tumour cells. Anticancer Res 1990; 10: 613–622.

    Google Scholar 

  5. Freitas I, Baronzio GF, Bertone V, Griffin P, Gerzeli G, Pontiggia P, Stoward PJ: Stroma formation in Ehrlich carcinoma: I. Oedema phase. A mitosis burst as an index of physiological reoxygenation? Anticancer Res, in press.

    Google Scholar 

  6. Rojkind M: From regeneration to scar: the collagen way. Lab Invest 1991; 64: 131–134.

    Google Scholar 

  7. Montesano R, Pepper MS, Mohle-Steinlein U, Risau W, Wagner EF, Orci L: Increased proteolytic activity is responsible for the aberrant morphogenetic behaviour of endothelial cells expressing the middle T oncogene. Cell 1990; 62: 435–445.

    Article  Google Scholar 

  8. Patterson WB (ed.): Wound Healing and Tissue Repair. University of Chicago Press, 1956, pp. 1–24.

    Google Scholar 

  9. Gasic GJ, Tuszynski G, Gorelik E: Interaction of the hemostatic and immune systems in the metastatic spread of tumor cells. Int Rev Exp Pathol 1986; 29: 173–212.

    Google Scholar 

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Freitas, I. et al. (1992). Tumor angiogenesis: evidence of new blood channels from plasma infiltrations. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_14

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  • DOI: https://doi.org/10.1007/978-3-0348-7001-6_14

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-7003-0

  • Online ISBN: 978-3-0348-7001-6

  • eBook Packages: Springer Book Archive

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