Abstract
The toxicity of DDT when administered by different routes offers unimpeachable evidence for the absorption of the compound by those routes. The time of onset of typical signs of intoxication gives some idea of the relative rates of absorption. Thus, rats injected intravenously at the rate of 50 mg/kg showed convulsions in 20 minutes, while those receiving DDT orally at the rate of 500 mg/kg showed convulsions only after 2 hours. Both groups of rats died in approximately 2 to 3 hours after the first convulsion. Signs appeared in animals injected intraperitoneally at the rate of 1,000 mg/kg after about 6 hours (Judah [313]).
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© 1959 Springer Basel AG
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Hayes, W.J., Simmons, S.W., Knipling, E.F. (1959). Physiology. In: Müller, P., Simmons, S.W. (eds) DDT: The Insecticide Dichlorodiphenyltrichloroethane and Its Significance / Das Insektizid Dichlordiphenyltrichloräthan und Seine Bedeutung. Chemische Reihe, vol 10 . Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6809-9_6
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DOI: https://doi.org/10.1007/978-3-0348-6809-9_6
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-6796-2
Online ISBN: 978-3-0348-6809-9
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