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Transcriptional Control Mechanisms Which Regulate the Expression of Human Metallothionein Genes

  • Michael Karin
  • Alois Haslinger
  • Adriana Heguy
  • Therese Dietlin
  • Richard Imbra
Part of the Experientia Supplementum book series (EXS, volume 52)

Abstract

The human genome contains at least 12 distinct metallothionein genes. The expression of these genes is regulated at the transcriptional levels by heavy metal ions, steroid hormones, interferon, interleukin 1 and phorbol esters. Comparisons of metallothionein gene sequences reveals a higher level of heterogeneity in the 5′ flanking control regions than in the coding regions. This is due to the presence of distinct promoter elements on each of the genes. These elements are responsible for inducer and tissue specificity of metallothionein gene expression.

Keywords

Enhancer Element Metallothionein Gene Glucocorticoid Responsive Element Southern California School SV40 Enhancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 1987

Authors and Affiliations

  • Michael Karin
    • 1
    • 2
  • Alois Haslinger
    • 1
  • Adriana Heguy
    • 1
  • Therese Dietlin
    • 1
  • Richard Imbra
    • 1
  1. 1.Department of MicrobiologyUniversity of Southern California School of MedicineLos AngelesUSA
  2. 2.Department of MicrobiologyUniversity of Southern California School of MedicineLos AngelesUSA

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