Skip to main content
SpringerLink
Log in
Book cover

Metallothionein II pp 257–264Cite as

Birkhäuser

Human Hepatic Metallothioneins: Resolution of Six Isoforms

  • Chapter

Part of the book series: Experientia Supplementum ((EXS,volume 52))

Abstract

Both by analytical and preparative reversed-phase high-performance liquid chromatography (HPLC) human hepatic metallothionein (MT) was resolved into six isoproteins. All six isoforms can be differentiated by amino acid analysis. One of the isoproteins is identical with the previously sequenced charge-separable form MT-2 while the remaining five are subforms of the less negatively charged MT-1 fraction. Comparison of the HPLC profiles obtained from postmortem liver samples of different individuals indicates that invariably all six isoMTs are present in human liver although their relative amounts are varying.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bühler, R.H.O. and Kägi, J.H.R. (1974) FEBS Lett. 39, 229–234.

    Article  Google Scholar 

  2. Kissling, M.M. and Kägi, J.H.R. (1979) In: “Metallothionein” J.H.R. Kägi and M. Nordberg, eds., Birkhäuser Verlag, Basel, pp. 145–151.

    Book  Google Scholar 

  3. Karin, M. and Richards, R.I. (1982b) Nature (London) 299, 797–802.

    Article  Google Scholar 

  4. Klauser, S., Kägi, J.H.R., and Wilson, K.J. (1983) Biochem. J. 209, 71–80.

    Google Scholar 

  5. Karin, M. and Richards, R.I. (1982a) Nucleic Acid Res. 10, 3173–3181.

    Article  Google Scholar 

  6. Hunziker, P.E., Kern, A., Looser, B., and Kägi, J.H.R., in preparation.

    Google Scholar 

  7. Richards, R.I., Heguy, A., and Karin, M. (1984) Cell (Cambridge, Mass.) 37, 263–272.

    Article  Google Scholar 

  8. Schmidt, C.J., Jubier, M.R., and Hamer, D.H. (1985) J. Biol. Chem. 260, 7731–7737.

    Google Scholar 

  9. Gedamu, L., personal communication.

    Google Scholar 

  10. Hunziker, P.E. and Kägi, J.H.R. (1985) Biochem. J. 231, 375–382.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biochemisches Institut, Universität Zürich, CH-8057, Zürich, Switzerland

    P. E. Hunziker & J. H. R. Kägi

Authors
  1. P. E. Hunziker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. H. R. Kägi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

    Jeremias H. R. Kägi

  2. Dept. of Environmental Medicine, Hokkaido University, Kita-ku, Sapporo, 060, Japan

    Yutaka Kojima

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Basel AG

About this chapter

Cite this chapter

Hunziker, P.E., Kägi, J.H.R. (1987). Human Hepatic Metallothioneins: Resolution of Six Isoforms. In: Kägi, J.H.R., Kojima, Y. (eds) Metallothionein II. Experientia Supplementum, vol 52. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6784-9_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-6784-9_20

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6786-3

  • Online ISBN: 978-3-0348-6784-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation