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Liposomes as Carriers for in Vivo Transfer and Expression of the Insulin Gene

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Modern Trends of Colloid Science in Chemistry and Biology

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Abstract

Recent studies have shown that, when injected intravenously, liposomes are taken up mainly in the liver and spleen by the macrophages of the reticulo-endothelial system (2–5). Intravenous injection of liposome entrapped molecules having long latency periods allows the transport of substantial amounts of such molecules to the cellular sites of liposome uptake, i.e., splenic macrophages and liver Kupffer cells (4,).

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Abbreviations

FACS:

fluorescence activated cell sorter

PBS:

phosphate buffered saline

PL:

phospholipids

PtdCho:

phosphatidylcholine

PtdSer:

phosphatidylserine

LC:

lactosylceramide

Choi:

cholesterol

TLC:

thin layer chromatography.

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Authors and Affiliations

  1. Centre de Biophysique Moléculaire, C.N.R.S., 1A, avenue de la Recherche Scientifique, 45045, Orléans Cédex, France

    C. Nicolau, A. Legrand & E. Grosse

Authors
  1. C. Nicolau
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  2. A. Legrand
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  3. E. Grosse
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Editor information

Editors and Affiliations

  1. Physikalisch-Chemisches Institut, Universität Basel, Klingelbergstrasse 80, CH-4056, Basel, Switzerland

    Hans-Friedrich Eicke

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© 1985 Springer Basel AG

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Nicolau, C., Legrand, A., Grosse, E. (1985). Liposomes as Carriers for in Vivo Transfer and Expression of the Insulin Gene. In: Eicke, HF. (eds) Modern Trends of Colloid Science in Chemistry and Biology. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6513-5_12

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  • DOI: https://doi.org/10.1007/978-3-0348-6513-5_12

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-7643-1711-9

  • Online ISBN: 978-3-0348-6513-5

  • eBook Packages: Springer Book Archive

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