Abstract
There has been considerable controversy as to the nature of the low molecular weight copper-binding protein present in liver and other tissues. Although it has been claimed (1–4) that the copper-induced protein in rat liver is not metallothionein there is a marked lack of agreement as to the amino acid composition and charge properties of the protein. The cysteine content has ranged from 2 to 14% and the protein has been reported to bind reversibly (3), irreversibly (2) or not at all (4) to anion-exchange columns. In contrast with these findings, Bremner and Young were able to isolate and unequivocally identify copper-thioneins from the livers of copper-injected rats (4) and also from pigs (5). Copper-thioneins have also been isolated from the livers of neonatal calves (6) and the kidneys of copper-poisoned sheep (7) and growing rats (8).
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References
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Bremner, I. (1979). Factors Influencing the Occurrence of Copper-Thioneins in Tissues. In: Kägi, J.H.R., Nordberg, M. (eds) Metallothionein. Experientia Supplementum, vol 34. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6493-0_20
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DOI: https://doi.org/10.1007/978-3-0348-6493-0_20
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