Abstract
In 1976 Kojima et al. (1) reported the first amino acid sequence of a metallothionein, equine renal MT-1B. Since then, the primary structures have been determined also for the form MT-1A of equine kidney (2,3) as well as for some metallothioneins of the liver of horse (3), man (4,5), rabbit (6), and mouse (7,8). From comparison of the various equine and human sequences we suggested tentatively that cells from euplacental mammals contain two different cistrons coding for metallothionein which may have evolved by duplication from an ancestral gene (5). This view has now received support also from the recently completed sequence studies of the two mouse isometallothioneins (7,8). In this paper, we report the N-terminal amino acid sequence of another rodent isometallothionein, rat MT-2, and document its very close relationship to mouse-MT-II.
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References
Kojima, Y., Berger, C., Vallee, B.L., and Kägi, J.H.R. (1976) Proc. Natl. Acad. Sci. USA 73, 3413–3417.
Kojima, Y. and Kägi, J.H.R. (1978) Trends Biochem. Sci. 3, 90–93.
Kojima, Y., Berger, C., and Kägi, J.H.R. (1979) This volume, pp. 153–161.
Kissling, M.M. and Kägi, J.H.R. (1977) FEBS Lett. 82, 247–250.
Kissling, M.M. and Kägi, J.H.R. (1979) This volume, pp. 145–151.
Kimura, M., Otaki, N., and Imano, M. (1979) This volume, pp. 163–168.
Huang, I-Y., Yoshida, A., Tsunoo, H., and Nakajima, H. (1977) J. Biol. Chem. 252, 8217–8221.
Huang, I-Y., Tsunoo, H., Kimura, M., Nakajima, H., and Yoshida, A. (1979) This volume, pp. 169–172.
Andersen, R.D., Winter, W.P., Mäher, J.J., and Bernstein, I.A. (1978) Biochem. J. 174, 327–338.
Winge, D.R., Premakumar, R., and Rajagopalan, K.V. (1975) Arch. Biochem. Biophys. 170, 242–252.
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Kissling, M.M., Berger, C., Kägi, J.H.R., Andersen, R.D., Weser, U. (1979). The Amino-Terminal Sequence of a Rat Liver Metallothionein (MT-2). In: Kägi, J.H.R., Nordberg, M. (eds) Metallothionein. Experientia Supplementum, vol 34. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6493-0_10
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DOI: https://doi.org/10.1007/978-3-0348-6493-0_10
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-6494-7
Online ISBN: 978-3-0348-6493-0
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