Do MAO-B Inhibitors Have Any Role in the Treatment of Depression?
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Parkinson’s disease (PD) is clearly associated with changes in affective state and a higher frequency of depression. Depressive symptoms have been found in about 70% of cases of PD , while depression that meets diagnostic criteria and significance is seen in about 40% of PD patients . There is no single type of depression in PD, but rather there are several different depressive syndromes related to the nature of the PD. Mayeux et al.  described depressed PD patients with sleep disturbances, fatigue, psychomotor retardation, and difficulty in concentrating as dominant complaints. Schiffer et al.  reported atypical depression with anxiety and panic disorder to be found significantly more frequently among patients with PD. According to Starkstein et al. , depressed patients with PD reported a significantly higher frequency of worrying, loss of interest, hopelessness, loss of appetite and libido, as well as anxiety, i.e., they showed a predominance of autonomic and affective symptoms. Interestingly, these authors found anergia and motor retardation to be not significantly more frequent in PD patients with depression. In recent years controlled studies have provided evidence that monoamine oxidase inhibitors (MAOIs) are effective antidepressants and comparable to (tricyclic) reuptake inhibitors.
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