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MAO-B Inhibitors in Neurological Disorders with Special Reference to Selegiline

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Book cover Inhibitors of Monoamine Oxidase B

Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

It has been shown that monoamines like serotonin and noradrenaline are preferentially metabolized in man by MAO-A, while benzylamine, phenylethylamine, and phenylethanolamine are specific substrates for MAO-B. Other monoamines are metabolized by both forms, but regional differences exist [1]. In the intestine, MAO-A is the dominant form, while MAO-B is preferentially found in platelets and in the brain, especially in the glial cells [2] (see Chapters 2, 6, 9).

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Authors
  1. K. Wessel
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Editors and Affiliations

  1. Dept. of Pharmacology, ASTA Medica AG, Weismüllerstrasse 45, D-6000, Frankfurt/Main 1, Germany

    I. Szelenyi

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© 1993 Springer Basel AG

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Wessel, K. (1993). MAO-B Inhibitors in Neurological Disorders with Special Reference to Selegiline. In: Szelenyi, I. (eds) Inhibitors of Monoamine Oxidase B. Milestones in Drug Therapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6348-3_13

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  • DOI: https://doi.org/10.1007/978-3-0348-6348-3_13

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6349-0

  • Online ISBN: 978-3-0348-6348-3

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