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Views on the Nature of the Gene, the Structure and Function of the Chromosome, and Heterochromatic Heredity

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Controversial Geneticist and Creative Biologist

Part of the book series: Experientia Supplementum ((EXS,volume 35))

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Abstract

Goldschmidt’s early acceptance of the classical definition of genes, as discrete, hereditary units, linearly arranged on chromosomes (derived from the Mendelian genetic analyses of the Morgan school) changed eventually to outright rejection1,2 when he considered the facts regarding position effects discovered by Sturtevant in 19253 in which physical rearrangements among the chromosomes lead to different activities of the same gene. He proposed an alternative model in 1938 (see below) in which the chromosome was the basic functional unit of heredity and any breakage or rearrangement within the chromosome would result in a change in the genetic functioning of the chain-like molecule as a whole.

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References

  1. R.B. Goldschmidt, Sci. Monthly 46: 268 (1938).

    Google Scholar 

  2. R.B. Goldschmidt, Physiological Genetics, McGraw-Hill Book Co. (1938).

    Google Scholar 

  3. A.H. Sturtevant, Genetics 10:117 (1925).

    Google Scholar 

  4. R.B. Goldschmidt, Science 43: 98 (1916).

    Article  Google Scholar 

  5. R.B. Goldschmidt, P.N.A.S. 2:53 (1916).

    Article  Google Scholar 

  6. R.B. Goldschmidt, Amer. Nat. 50:705 (1916).

    Article  Google Scholar 

  7. R.B. Goldschmidt, Nature 107: 780 (1921).

    Article  Google Scholar 

  8. R.B. Goldschmidt, Genetics 20:1 (1938).

    Google Scholar 

  9. R.B. Goldschmidt, Quart. Rev. Biol. 3: 307 (1928).

    Google Scholar 

  10. R.B. Goldschmidt, Theoretical Genetics, University of California Press (1955).

    Google Scholar 

  11. O.T. Avery, C.M. MacLeod, M. McCarty, J. Exp. Med. 79: 137 (1944).

    Article  Google Scholar 

  12. A.D. Hershey and M. Chase, J. Gen. Physiol. 36: 39 (1952).

    Article  Google Scholar 

  13. J.D. Watson and F.H. Crick, Nature 171:737 (1953).

    Google Scholar 

  14. J.D. Watson and F.H. Crick, Nature 171: 964 (1953).

    Article  Google Scholar 

  15. S. Benzer, P.N.A.S. 41: 344 (1955).

    Article  Google Scholar 

  16. S. Benzer, in “The Chemical Basis of Heredity” (McElroy and Glass, eds.) Johns Hopkins Press (1957).

    Google Scholar 

  17. S. Benzer, P.N.A.S. 47: 403 (1961).

    Article  Google Scholar 

  18. M.W. Nirenberg and J.H. Matthei, P.N.A.S. 47: 1588 (1961).

    Article  Google Scholar 

  19. P. Lengyel, J. Speyer, and S. Ochoa, P.N.A.S. 47: 1936 (1961).

    Article  Google Scholar 

  20. C. Yanofsky, B.C. Carlton, J.R. Guest, D.R. Helinski, U. Henning, P.N.A.S. 51: 266 (1964).

    Article  Google Scholar 

  21. F. Jacob and J. Monod, J. Mol. Biol. 3: 318 (1961).

    Article  Google Scholar 

  22. A. Chovnick, W. Gelbart, M. McCarron and B. Osmond, Genetics 84: 233 (1976).

    Google Scholar 

  23. T.F.R. Wright, G.C. Bewley, and A.F. Sherald, Genetics 84: 287 (1976).

    Google Scholar 

  24. O.L. Miller, Jr. and B. Beatty, Science 164: 955 (1969).

    Article  Google Scholar 

  25. B.A. Hamkalo and O.L. Miller, Jr., in “Gene Expression and its Regulation”, Plenum Press (1971).

    Google Scholar 

  26. U. Laemmli, Cell 3: 817 (1977).

    Google Scholar 

  27. J.G. Gall, Nature 198: 36 (1963).

    Article  Google Scholar 

  28. R. Kavenoff and B.H. Zimm, Chromosoma 41: 1 (1973).

    Article  Google Scholar 

  29. B. Daneholt, Nature 240: 229 (1972).

    Google Scholar 

  30. W. Beerman, Chromosoma 5: 139 (1952).

    Article  Google Scholar 

  31. M. Kodani, J. Heredity 33: 115 (1942).

    Google Scholar 

  32. M. Kodani, Genetics 32: 18 (1949).

    Google Scholar 

  33. R.B. Goldschmidt, E. Gardner, and M. Kodani, P.N.A.S. 25: 314 (1939).

    Article  Google Scholar 

  34. J.G. Gall and H.G. Callan, P.N.A.S. 48: 562 (1962).

    Article  Google Scholar 

  35. O.L. Miller, Jr. and A.H. Bakken, Acta Endoc. 168:155 (1972).

    Google Scholar 

  36. E. Heitz, Ber. deutsch. bot. Ges. 47: 274 (1929).

    Google Scholar 

  37. M.F. Lyon, Nature 190: 372 (1961).

    Article  Google Scholar 

  38. W.K. Baker, Ann. Rev. Genetics 14: 133 (1968).

    Article  Google Scholar 

  39. R.B. Goldschmidt, Hereditas (Suppl.), p. 244 (1949).

    Google Scholar 

  40. R.B. Goldschmidt, A. Hannah, and L.K. Piternick, Univ. Cal. Publ. Zool. 55:67 (1951).

    Google Scholar 

  41. R.B. Goldschmidt, J. Exp. Zool. 119: 405 (1952).

    Article  Google Scholar 

  42. J.G. Gall, E.H. Cohen, and M.L. Polan, Chromosoma 33: 319 (1971).

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Zoology, University of Washington, Seattle, WA, 98195, USA

    Aimée H. Bakken

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  1. Aimée H. Bakken
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Editor information

Editors and Affiliations

  1. University of Washington, Seattle, Wash., USA

    Leonie K. Piternick

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© 1980 Springer Basel AG

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Bakken, A.H. (1980). Views on the Nature of the Gene, the Structure and Function of the Chromosome, and Heterochromatic Heredity. In: Piternick, L.K. (eds) Controversial Geneticist and Creative Biologist. Experientia Supplementum, vol 35. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5855-7_6

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  • DOI: https://doi.org/10.1007/978-3-0348-5855-7_6

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5857-1

  • Online ISBN: 978-3-0348-5855-7

  • eBook Packages: Springer Book Archive

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