Stucture-Activity Relationships in a Series of Cinnamic Acids in the Stabilizing Action on Erythrocyte Membrane
Recently it was found that nonsteroidal antiinflammatory agents of acidic character protect canine and human erythrocytes from hypotonic haemolysis. In view of the marked antiinflammatory activity found in arylaliphatic acids, we synthesized a series of cinnamic acids substituted on the aromatic ring and branched in the α-position in relation to the carboxyl group (Fig. 1). These compounds were concurrently tested for both antiinflammatory activity and stabilizing action on rat erythrocytes as suitable model membranes. This latter effect was correlated with physico-chemical properties of the compounds by the regression analysis method.
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