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In Vitro Dissolution Rate as a Parameter in Structure-Activity Studies

  • J. C. Dearden
  • J. H. Collett
  • E. Tomlinson
Part of the Experientia Supplementum book series (EXS, volume 23)

Abstract

In the last decade, many attempts have been made to correlate biological activity with physico-chemical factors, both empirical and theoretical. Of these factors, partition coefficient has emerged as perhaps the most significant, and it has often been shown that the variation of biological activity within a series of compounds can be accounted for largely by variation in partition coefficient.

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References

  1. 1.
    Dearden, J. C. and Tomlinson, E., J. Pharm. Pharmacol. 23, 73S (1971).CrossRefGoogle Scholar
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    Dearden, J. C. and Tomlinson, E., J. Pharm. Pharmacol. 24, 115P (1972).CrossRefGoogle Scholar
  3. 3.
    Collier, H.O., Dineen, L.C., Johnson, C.A. and Schneider, C., Brit. J. Pharmacol. Chemother. 32, 295 (1968).CrossRefGoogle Scholar
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    Hansch, C., Quinlan, J.E. and Lawrence, G.L., J. org. Chem. 33, 347 (1968).CrossRefGoogle Scholar

Copyright information

© Springer Basel AG 1976

Authors and Affiliations

  • J. C. Dearden
    • 1
    • 2
  • J. H. Collett
    • 1
    • 2
  • E. Tomlinson
    • 1
    • 2
  1. 1.School of Pharmacy, Liverpool Polytechnic, Department of PharmacyUniversity of ManchesterEngland
  2. 2.Department of PharmacyUniversity of Aston in BirminghamEngland

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