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Relationships Among Activity Coefficients, Partition Coefficients and Solubilities

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Book cover Quantitative Structure-Activity Relationships

Part of the book series: Experientia Supplementum ((EXS,volume 23))

Abstract

The partition coefficient of a compound in a partitioning system of two liquid phases is the most frequently used characteristics for structure-activity relationships. Thanks to Hansch and his co-workers, partition coefficients of compounds in the octanol/water system have become universally and very successfully used [1].

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References

  1. Leo, A., Hansch C. and Elkins, D., Chem. Rev. 71, 525 (1971).

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  2. Meyer, H., Arch. exp. Pathol. Pharmacol. 42, 109 (1899).

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  3. Meyer, K.H. and Hemmi, H., Biochem. Z. 277, 39 (1935).

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  5. Boyce, C.B.C. and Milborrow, B.V., Nature (London) 208, 537 (1965).

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© 1976 Springer Basel AG

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Boček, K. (1976). Relationships Among Activity Coefficients, Partition Coefficients and Solubilities. In: Tichý, M. (eds) Quantitative Structure-Activity Relationships. Experientia Supplementum, vol 23. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5795-6_33

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  • DOI: https://doi.org/10.1007/978-3-0348-5795-6_33

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5796-3

  • Online ISBN: 978-3-0348-5795-6

  • eBook Packages: Springer Book Archive

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