Skip to main content

Chemical Structure-Biological Activity Relationships in the Phenoxyacetic Acid Series

  • Chapter
Quantitative Structure-Activity Relationships

Part of the book series: Experientia Supplementum ((EXS,volume 23))

Abstract

Many phenoxyacetic acids show interesting hypocholesterolaemic and anti-lipolytic activity. So reported Thorp [1] 74% of the 116 investigated phenoxyacetic acids to be active. Hundreds of analogues have since been synthesised and some have successfully entered medical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Thorp, J.M., J. Atherosclerosis Res. 3, 351 (1963).

    Article  Google Scholar 

  2. Thorp, J.M., Lancet. 1, 1323 (1962).

    Article  Google Scholar 

  3. Kariya, T., Grisar, J.M., Wiech, N.L. and Blohm, T.R., J. med. Chem. 15, 659 (1972).

    Article  Google Scholar 

  4. Hoffmann, R., J. chem. Phys. 39, 1397 (1963).

    Article  Google Scholar 

  5. Zeelen, F. J., in: Medicinal Chemistry related to Dopamine. Section of Medicinal Chemistry Royal Netherlands Chemical Society, p. 22 (1972). Zeelen, F. J. Rec. Trav. Chim. in press. (1973).

    Google Scholar 

  6. Grisar, J.M., Parker, R.A., Kariya, T., Blohm, T.R., Fleming, R.W., Petrow, V., Wenstrup. D.L. and Johnson, R.G., J. med. Chem. 15, 1273 (1972).

    Article  Google Scholar 

  7. Witiak, D.T., Chun-Lun Ho, T., Hackney, R.E. and Connor, W.E., J. med. Chem. 11, 1086 (1968).

    Article  Google Scholar 

  8. Witiak, D.T., Hackney, R.E. and Whitehouse, M.W., J. med. Chem. 12, 697 (1969).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Springer Basel AG

About this chapter

Cite this chapter

Zeelen, F.J. (1976). Chemical Structure-Biological Activity Relationships in the Phenoxyacetic Acid Series. In: Tichý, M. (eds) Quantitative Structure-Activity Relationships. Experientia Supplementum, vol 23. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5795-6_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-5795-6_23

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5796-3

  • Online ISBN: 978-3-0348-5795-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics