Abstract
It is well known that hydrophobicity has a strong influence on biological activity in many series of drugs. As suggested by Hansch [1, 2] this influence may be due to transport processes, but it may also be due to hydrophobic interactions with a recepting protein [3, 4]. The purpose of the present paper is to discuss some criteria which may be helpful to discriminate between these two possibilities and, furthermore, to show that hydrophobic interactions probably dominate over transport in much more cases than is generally believed at present.
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© 1976 Springer Basel AG
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Franke, R. (1976). On the Parabolic Relationship Between Biological Activity and Hydrophobicity of Drugs: Transport or Protein Binding?. In: Tichý, M. (eds) Quantitative Structure-Activity Relationships. Experientia Supplementum, vol 23. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5795-6_2
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DOI: https://doi.org/10.1007/978-3-0348-5795-6_2
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-5796-3
Online ISBN: 978-3-0348-5795-6
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