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Structure-Toxicity Relationships

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Part of the book series: Experientia Supplementum ((EXS,volume 23))

Abstract

The acute toxic effects in mice of either sex and 18–23 g of body weight were studied after oral (p. o.), intraperitoneal (i. p.) and intravenous (i. v.) administration of a homologous series of eleven l-ethyl piperidine derivatives (substances Nos 1–11 — first group) and three substances (Nos 12–14 — second group) of identical side alkyl chains but different basic chemical structures (Fig. 1). It was attempted to find the toxicologically most suitable substance and to study the structure-toxicity relationships. After termination of the study of structure-toxicity relationships further four substances were synthesized and examined (see Fig. 5, substances A, B, C., and No. 20) to confirm the conclusions of this study.

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References

  1. Litchfield, J.T., Jr. and Wilcoxon, F., J. Pharmacol. exp. Ther. 96, 99 (1949)

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  2. Barnes, C. D. and Eltherington, L. G., in: Drug dosage in laboratory animals. University of California Press, Berkeley and Los Angeles, 1965.

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© 1976 Springer Basel AG

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Vrbovský, L. (1976). Structure-Toxicity Relationships. In: Tichý, M. (eds) Quantitative Structure-Activity Relationships. Experientia Supplementum, vol 23. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5795-6_19

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  • DOI: https://doi.org/10.1007/978-3-0348-5795-6_19

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-5796-3

  • Online ISBN: 978-3-0348-5795-6

  • eBook Packages: Springer Book Archive

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