Abstract
The acute toxic effects in mice of either sex and 18–23 g of body weight were studied after oral (p. o.), intraperitoneal (i. p.) and intravenous (i. v.) administration of a homologous series of eleven l-ethyl piperidine derivatives (substances Nos 1–11 — first group) and three substances (Nos 12–14 — second group) of identical side alkyl chains but different basic chemical structures (Fig. 1). It was attempted to find the toxicologically most suitable substance and to study the structure-toxicity relationships. After termination of the study of structure-toxicity relationships further four substances were synthesized and examined (see Fig. 5, substances A, B, C., and No. 20) to confirm the conclusions of this study.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Litchfield, J.T., Jr. and Wilcoxon, F., J. Pharmacol. exp. Ther. 96, 99 (1949)
Barnes, C. D. and Eltherington, L. G., in: Drug dosage in laboratory animals. University of California Press, Berkeley and Los Angeles, 1965.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer Basel AG
About this chapter
Cite this chapter
Vrbovský, L. (1976). Structure-Toxicity Relationships. In: Tichý, M. (eds) Quantitative Structure-Activity Relationships. Experientia Supplementum, vol 23. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5795-6_19
Download citation
DOI: https://doi.org/10.1007/978-3-0348-5795-6_19
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-5796-3
Online ISBN: 978-3-0348-5795-6
eBook Packages: Springer Book Archive