Abstract
The proton conductance of the inner membrane of hamster brown adipose tissue mitochondria can be regulated in vitro by exogenous purine nucleotides, which “bind to a component on the outer face of the inner membrane. This unique mechanism has been proposed to represent the molecular site of non-shivering thermogenesis in this tissue. Using a photo-affinity analogue of ATP, we have identified the nucleotide binding component as a protein of 32,000 daltons.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cannon, B., Sundin, U. and Romert, L.: FEBS Lett. 74 (1977) 43–46.
Flatmark, T. & Pederson, J.I.: Biochim.Biophys.Acta 416 (1975) 53–103.
Mitchell, P.: Biochem.Soc.Trans. 4 (1976) 399–430.
Mcholls, D.G.: Ear. J. Biochem. 49 (1974) 573–583.
Mcholls, D.G.: Ear. J. Biochem. 62 (1976) 223–228.
Mcholls, D.G.: FEBS Lett. 61 (1976) 103–110.
Nicholls, D.G. and Bernson, V.S.M.: Ear. J. Biochem. (in press).
Nicholls, D.G. and Lindberg, O.: Ear. J. Biochem. 37 (1973) 523–530.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer Basel AG
About this paper
Cite this paper
Nicholls, D.G., Bernson, V.S.M., Heaton, G.M. (1978). The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Responsible for Regulating Energy Dissipation. In: Girardier, L., Seydoux, J. (eds) Effectors of Thermogenesis. Experientia Supplementum, vol 32. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5559-4_9
Download citation
DOI: https://doi.org/10.1007/978-3-0348-5559-4_9
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-5561-7
Online ISBN: 978-3-0348-5559-4
eBook Packages: Springer Book Archive