Abstract
Thyroid hormones have been known to increase renal plasma flow (RPF), glomerular filtration rate (GFR), and filtered Na+-load. It was proposed that the increase in (Na+ + K+)-Adenosine Triphosphatase activity might have been an adaptive response to an increase in filtered Na+-load. The present study was undertaken to test this hypothesis. The results indicate that the effect of triiodothyronine (T3) on the (Na+ + K+)-Adenosine Triphosphatase activity precedes its effect on the RPF, GFR, and filtered Na+-load. T3 probably has a direct effect on the de novo synthesis of this enzyme in the rat kidney cortex.
This work was financially supported by the American Heart Assoc, Maryland Affiliated, Inc. Grant 3MC8-AP.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Asano, Y., U. Liberman, I.S. Edelman: Effect of Thyroid hormone on NaK-ATPase activity and oxygen consumption in rat skeletal muscle. J. Clin. Invest. 57(1976):368–379.
Discala, V.A. and M.T. Kinney: Effects of myxedema on renal diluting and concentrating mechanisms. Am. J. Med. 50 (1971) 325–335.
Holmes, E.W. and V.A. Discala: Studies on the exaggerated natriutetic response to saline infusion in the hypothyroid rat. J. Clin. Invest. 49 (1970) 1224–1236.
Ismail-Beigi, F., I.S. Edelman: Mechanisms of thyroid calorigenesis: Role of active Na+ transport. Proc. Nat’l Acad. Sci. 67 (1970) 1071–1078.
Ismail-Beigi, F., I.S. Edelman: The mechanism of the Calorigenic action of thyroid hormone. Stimulation of Na+ and K+ activated ATPase. J. Gen. Physiol. 57 (1971) 710–722.
Katz, A-I and M.D. Lindheimer: Renal NaK-ATPase and Na+ reabsorption in the hypothyroid rat. J. Clin. Invest. 52 (1973) 796–804.
Lo, C.S., T. August, U. Liberman and I.S. Edelman: Dependence of renal NaK-ATPase activity on thyroid status. J. Biol. Chem. 25 (1976) 7826–7833.
Lo, C.S. and I.S. Edelman: Effect of Triiodothyronine on the synthesis and degradation of renal cortical NaK-ATPase. J. Biol. Chem. 251 (1976) 7834–7840.
Michael, V.F., R.L. Barenberg, R. Chanez, C.A. Vaamonde, and S. Papper: Renal handling of Na and H2O in the hypothyroid rat. J. Clin. Invest. 51 (1972) 1405–1412.
Philipson, K.D. and I.S. Edelman: Thyroid hormone control of Na+K+-ATPase and K+-dependent phosphatase in rat heart. Amer. J. Physiol. 1 (3) (1977) C196–C201.
Philipson, K.D. and I.S. Edelman: Characteristics of thyroid stimulated Na+-K+ ATPase of rat heart. Amer. J. Physiol. 1 (3) (1977) C–202–C–206.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer Basel AG
About this paper
Cite this paper
Lo, CS., Lo, T.N. (1978). Thyroidal Regulation of Renal Functions and of Renal Cortical Adenosine Triphosphatase Activity in the Rat. In: Girardier, L., Seydoux, J. (eds) Effectors of Thermogenesis. Experientia Supplementum, vol 32. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5559-4_24
Download citation
DOI: https://doi.org/10.1007/978-3-0348-5559-4_24
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-5561-7
Online ISBN: 978-3-0348-5559-4
eBook Packages: Springer Book Archive