Abstract
Lactate, although an end product of anaerobic glycolysis, is also a substrate for oxidative metabolism. Thus, it is well-known that lactate is taken up and oxidized by the myocardium at a rate proportional to the level in the blood [1]. It has also been demonstrated that lactate is taken up [2] and oxidized [3] by working skeletal muscle. In this regard, lactate is a suitable substrate since it can readily enter the cell and the aerobic pathways with minimum of molecular modification. An unanswered question is if the uptake of lactate may be influenced by the availability of glycogen in the working muscle. Thus, the purpose of the present study was to examine the relationship between the relative production end uptake of lactate by human skeletal muscle during exercise at different glycogen levels of the skeletal muscle.
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References
Goodale, W. T., Olson, R. E. and Hackel, D. B.: The effects of fasting and diabetes mellitus on myocardial metabolism in man. Amer. J. Med. 27, 212–220 (1959).
Stainsby, W. N. and Welch, H. G.: Lactate metabolism of contracting dog skeletal muscle in situ. Amer. J. Physiol. 211, 177–183 (1966).
Jorfeldt, L.: Metabolism of L(+)-lactate in human skeletal muscle during exercise. Acta Physiol. Scand., suppl. 338 (1970).
BergstrÖM, J.: Muscle electrolytes in man. Scand. J. clin. Lab. Invest., suppl. 68 (1962).
Karlsson, J.: Lactate and phosphagen concentration in working muscle of man with special reference to oxygen deficit at onset of work. Acta Physiol. Scand., suppl. 358 [ 1971 ).
Padykula, H. A. and Herman, E.: The specificity of the histochemical method of adenosine triphosphatase. J. Histochem. Cytochem. 3, 170–195 (1955).
Pearse, A. G.E.: Histochemistry-Theoretical and Applied. Boston: Little Brown, appendix 9, 832 (1961).
Gollnick, P. D., Armstrong, R. B., Saubert IV, C. W., Piehl, K. and Saltin, B.: Enzyme activity and fiber composition in skeletal muscle of trained and untrained men. J. Appl. Physiol. 33, 312–319 (1972).
Gollnick, P.D., SJÖDin, B., Karlsson, J., Jansson, E. and Saltin, B.: Human Soleus Muscle: A Comparison of Fiber Composition and Enzyme Activities with other Leg Muscles. Pflügers Arch. 348, 247–255 (1974).
Grimby, L. and Hannerz, J.: Recruitment order of motor units on voluntary contraction: changes induced by proprioceptive afferent activity. J. Neurol. Psychiat. 31, 565–573 (London 1968 ).
Wahren, J., Felig, P., Ahlborg, G. and Jorfeldt, L.: Glucose metabolism during leg exercise in man. J. Clin. Invest. 50, 2715–2725 (1971).
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© 1975 Springer Basel AG
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Essén, B., Pernow, B., Gollnick, P.D., Saltin, B. (1975). Muscle Glycogen Content and Lactate Uptake in Exercising Muscles. In: Howald, H., Poortmans, J.R. (eds) Metabolic Adaptation to Prolonged Physical Exercise. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5523-5_16
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DOI: https://doi.org/10.1007/978-3-0348-5523-5_16
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-7643-0725-7
Online ISBN: 978-3-0348-5523-5
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