Hypothetic Interindividual and Interspecies Relevance of microRNAs Released in Body Fluids

  • Ivan Igaz
  • Peter IgazEmail author
Part of the Experientia Supplementum book series (EXS, volume 106)


MicroRNAs may not only be relevant within the organism, but microRNAs released in body fluids might affect other individuals and hypothetically also other species. Such interindividual and cross-species activity of microRNAs appears to be very interesting, but these actions are largely hypothetic at present warranting extensive experimental validation. Food-derived microRNAs might extend the relevance of food for epigenetic regulation; however, the efficient gastrointestinal transfer of microRNAs needs to be demonstrated. We have raised the hypothesis that the nonprotein coding “dark matter” of the genome containing microRNA genes might be relevant in the regulation of interindividual and interspecies epigenetic communication.


microRNA Cross-species Cross-kingdom Interindividual Interspecies 


  1. Baier SR, Nguyen C, Xie F et al (2014a) MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. J Nutr 144:1495–1500CrossRefPubMedPubMedCentralGoogle Scholar
  2. Baier SR, Xie F, Zempleni J (2014b) Reply to Witwer. J Nutr 144:1882PubMedGoogle Scholar
  3. Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136:215–233CrossRefPubMedPubMedCentralGoogle Scholar
  4. Catalgol B, Batirel S, Taga Y et al (2012) Resveratrol: French paradox revisited. Front Pharmacol 3:141CrossRefPubMedPubMedCentralGoogle Scholar
  5. Curry A (2013) Archaeology: the milk revolution. Nature 500:20–22CrossRefPubMedGoogle Scholar
  6. Djebali S, Davis CA, Merkel A et al (2012) Landscape of transcription in human cells. Nature 489:101–108CrossRefPubMedPubMedCentralGoogle Scholar
  7. Hirschi KD (2012) New foods for thought. Trends Plant Sci 17:123–125CrossRefPubMedGoogle Scholar
  8. Howard KM, Jati Kusuma R et al (2015) Loss of miRNAs during processing and storage of cow’s (Bos taurus) milk. J Agric Food Chem 63:588–592CrossRefPubMedPubMedCentralGoogle Scholar
  9. Igaz I, Igaz P (2015) Possible role for microRNAs as inter-species mediators of epigenetic information in disease pathogenesis: is the non-coding dark matter of the genome responsible for epigenetic interindividual or interspecies communication? Med Hypotheses 84:150–154CrossRefPubMedGoogle Scholar
  10. Karnani M, Annila A (2009) Gaia again. Bio Systems 95:82–87CrossRefPubMedGoogle Scholar
  11. LaMonte G, Philip N, Reardon J et al (2012) Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Cell Host Microbe 12:187–199CrossRefPubMedPubMedCentralGoogle Scholar
  12. Lancon A, Kaminski J, Tili E et al (2012) Control of MicroRNA expression as a new way for resveratrol to deliver its beneficial effects. J Agric Food Chem 60:8783–8789CrossRefPubMedGoogle Scholar
  13. Liang H, Huang L, Cao J et al (2012) Regulation of mammalian gene expression by exogenous microRNAs. Wiley Interdiscip Rev RNA 3:733–742CrossRefPubMedGoogle Scholar
  14. Melnik BC (2015) The pathogenic role of persistent milk signaling in mTORC1- and milk- microRNA-driven type 2 diabetes mellitus. Curr Diabetes Rev 11:46–62CrossRefPubMedPubMedCentralGoogle Scholar
  15. Melnik BC, John S, Schmitz G (2015) Milk consumption during pregnancy increases birth weight, a risk factor for the development of diseases of civilization. J Transl Med 13:13CrossRefPubMedPubMedCentralGoogle Scholar
  16. Melnik BC, John SM, Schmitz G (2013) Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr J 12:103CrossRefPubMedPubMedCentralGoogle Scholar
  17. Melnik BC, John SM, Schmitz G (2014) Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy? J Transl Med 12:43CrossRefPubMedPubMedCentralGoogle Scholar
  18. Snow JW, Hale AE, Isaacs SK et al (2013) Ineffective delivery of diet-derived microRNAs to recipient animal organisms. RNA Biol 10:1107–1116CrossRefPubMedPubMedCentralGoogle Scholar
  19. Witwer KW (2012) XenomiRs and miRNA homeostasis in health and disease: evidence that diet and dietary miRNAs directly and indirectly influence circulating miRNA profiles. RNA Biol 9:1147–1154CrossRefPubMedPubMedCentralGoogle Scholar
  20. Witwer KW (2014) Diet-responsive mammalian miRNAs are likely endogenous. J Nutr 144:1880–1881CrossRefPubMedGoogle Scholar
  21. Witwer KW, Hirschi KD (2014) Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist. BioEssays 36:394–406CrossRefPubMedPubMedCentralGoogle Scholar
  22. Yang L, Froberg JE, Lee JT (2014) Long noncoding RNAs: fresh perspectives into the RNA world. Trends Biochem Sci 39:35–43CrossRefPubMedGoogle Scholar
  23. Zhang L, Hou D, Chen X et al (2012a) Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 22:107–126CrossRefPubMedGoogle Scholar
  24. Zhang Y, Wiggins BE, Lawrence C et al (2012b) BMC Genomics 13:381CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of GastroenterologySzt Imre Teaching Hospital BudapestBudapestHungary
  2. 2.2nd Department of MedicineSemmelweis UniversityBudapestHungary

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