Abstract
Indacaterol has a 24 h bronchodilatory effect, which allows the drug to be effective with once-daily administration. The speed of onset of bronchodilation after inhalation of indacaterol is as fast as that seen for salbutamol and formoterol. Compared to placebo, significant improvements are seen 5 min after dosing.
Patients with COPD who received indacaterol 150 μg or 300 μg once daily in large (n > 400), randomized, double-blind, placebo-controlled, multicenter phase 3 trials had a significantly higher mean trough FEV1 compared to placebo after 12 weeks treatment. The absolute differences in trough FEV1 between indacaterol and placebo were 130–180 ml and exceeded the predetermined clinically relevant threshold of 120 ml in all trials.
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Dahl, R. (2014). Phase 3 Clinical Efficacy Studies: Lung Function. In: Trifilieff, A. (eds) Indacaterol. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-0348-0709-8_6
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DOI: https://doi.org/10.1007/978-3-0348-0709-8_6
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