Abstract
Since the discovery of IL-17 expression in synovial fluid and biopsies in RA patients, the role of this proinflammatory T cell cytokine in arthritis has been extensively studied using animal models of arthritis. In this chapter, an overview is given of the most important publications elucidating the role of IL-17 in the onset and the progression of experimental arthritis. IL-17 is essential for normal T and B cell development but is also locally involved in the arthritic process, enhancing the expression of proinflammatory cytokines and chemokines. IL-17 also contributes to joint destruction directly by upregulation of MMPs and stimulating osteoclastogenesis through RANKL induction. The recently discovered Th17 cell is regarded as the main source of IL-17, and the influence of IL-12/IL-23 and other mediators in experimental arthritis will be discussed.
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Koenders, M.I., van den Berg, W.B. (2013). Critical Role of IL-17 in Experimental Arthritis. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_9
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