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IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity pp 321–331Cite as

Genetic Mouse Models to Investigate IL-17 Responses

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Th17 cells have recently acquired notoriety after their association with tissue inflammation. IL-17A secretion is considered the hallmark of Th17 function. It exhibits strong proinflammatory properties and is considered to be a major driving force in the pathogenesis of autoimmunity. A vast amount of data is now available, highlighting the complex role of IL-17 family cytokines and their functions in physiological processes. As a consequence of the burst of interest surrounding these cytokines, new mouse strains have been developed to study their roles in pathogenic processes. In this chapter, examples of the knowledge gained using mice designed to track IL-17-expressing cell types, alter IL-17A expression or disrupt IL-17 signalling are delineated. Also, current options available for generating such strains and their potential drawbacks are discussed.

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Authors and Affiliations

  1. Institute of Experimental Immunology, University of Zurich, Winterthurerstr. 190, Zürich, CH-8057, Switzerland

    Andrew L. Croxford Ph.D. & Thorsten Buch

  2. Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Trogerstrasse 30, Munich, 81675, Germany

    Thorsten Buch

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  1. Andrew L. Croxford Ph.D.
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Correspondence to Andrew L. Croxford Ph.D. .

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Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Valérie Quesniaux

  2. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Bernhard Ryffel

  3. Novartis Institute for Biomedical, Research (NIBR), Novartis Pharma AG, Basel, 4002, Switzerland

    Franco Padova

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Croxford, A.L., Buch, T. (2013). Genetic Mouse Models to Investigate IL-17 Responses. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_23

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  • DOI: https://doi.org/10.1007/978-3-0348-0522-3_23

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