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Is IL-17 Required to Control Tuberculosis?

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IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Herein we review the state of knowledge regarding the role of IL-17 in tuberculosis (TB). IL-17 is induced following exposure to mycobacteria in mice and humans, yet its role in protection and the immunopathologic consequences of infection is not defined. It appears that the IL-17 response to mycobacterial infection is dependent on IL-23 and that the induction of this cytokine is dependent upon pathogen-associated molecules on the surface of the mycobacterium. While there is evidence for a protective role, there is also evidence for a pathologic role; it is therefore critical to decipher the impact of IL-17 so that preventive and therapeutic measures can be appropriately tailored.

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Authors and Affiliations

  1. Trudeau Institute, Inc, Saranac Lake, NY, 12983, USA

    Andrea M. Cooper

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  1. Andrea M. Cooper
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  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Valérie Quesniaux

  2. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Bernhard Ryffel

  3. Novartis Institute for Biomedical, Research (NIBR), Novartis Pharma AG, Basel, 4002, Switzerland

    Franco Padova

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Cooper, A.M. (2013). Is IL-17 Required to Control Tuberculosis?. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_14

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