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Inflammasome: IL-1/IL-17 Response in Lung Inflammation

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IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Airway exposure to endotoxin and other microbial TLR agonists induces a rapid production of mediators including IL-1 and IL-17, neutrophil recruitment, and bronchoconstriction which are abrogated in mice deficient for distinct TLRs or the common adaptor molecule myeloid differentiation factor 88 (MyD88). Furthermore, administration of IL-1β mobilizes neutrophils and induces IL-17 production in the lung. Therefore, IL-17 participates in IL-1β-induced lung inflammation. Importantly, lung injury by particles, chemicals, and allergens activates the NLPR3 inflammasome complex leading to the cleavage of pro-IL-1β into active IL-1β- and IL-17-dependent inflammation and repair. In conclusion, TLR agonists and lung injury induces the activation of the NLPR inflammasome with maturation of IL-1β leading to IL-17-dependent lung inflammation.

Grant support by “Ministère de l’Education Nationale, de la Recherche et de la Technologie,” Fondation de la Recherche, and CNRS. The work was also supported by grants from Le Studium (Orleans), Biomedical Research Foundation, and Fondation de la Recherche Médicale.

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Abbreviations

LPS:

Lipopolysaccharide

TLR:

Toll-like receptor

TIR:

Toll-interleukin 1 receptor

TIRAP:

TIR-domain-containing adaptor protein

TRIF:

TIR-domain-containing adaptor-inducing interferon-β

Penh:

Enhanced respiratory pause

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Author information

Authors and Affiliations

  1. CNRS UMR7355, INEM, Orleans, 45071, France

    Isabelle Couillin, Mamdouh Sedhom, Marc Le Bert, Hana Čipčić Paljetak, Francois Erard & Bernhard Ryffel

  2. University Capetown, 1101717, Capetown, RSA

    Isabelle Couillin & Bernhard Ryffel

  3. UMR7355 INEM, Experimental and Molecular Immunology and Neurogenetics, CNRS et Université d’Orleans, Orleans - Cedex 2, France

    Isabelle Couillin & Bernhard Ryffel

  4. Artimmune SAS, Orleans, France

    Dieudonnée Togbe

  5. Biomedical Research Foundation, SBF, Matzingen, Switzerland

    René Moser

Authors
  1. Isabelle Couillin
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  2. Dieudonnée Togbe
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  3. Mamdouh Sedhom
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  4. Marc Le Bert
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  8. Bernhard Ryffel
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Corresponding author

Correspondence to Isabelle Couillin .

Editor information

Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Valérie Quesniaux

  2. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orleans CX 2, 45071, France

    Bernhard Ryffel

  3. Novartis Institute for Biomedical, Research (NIBR), Novartis Pharma AG, Basel, 4002, Switzerland

    Franco Padova

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Couillin, I. et al. (2013). Inflammasome: IL-1/IL-17 Response in Lung Inflammation. In: Quesniaux, V., Ryffel, B., Padova, F. (eds) IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0522-3_11

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  • DOI: https://doi.org/10.1007/978-3-0348-0522-3_11

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