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Clinical Efficacy

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Ibuprofen: Pharmacology, Therapeutics and Side Effects

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Abstract

The clinical efficacy of ibuprofen has been shown in a wide variety of painful and inflammatory states, including rheumatoid arthritis (RA), osteoarthritis (OA) and other musculo-skeletal conditions. Its effects at prescription level dosage (1,800–2,400 mg/day) have been shown in a large number of clinical trials. Generally it has comparable effects in relief of pain and joint symptoms to other NSAIDs, including the newer COX-2-selective agents (coxibs). The differences in effects with longer half-life drugs may relate to dose and duration of drug use. In the dental pain, throat pain, headache and fever clinical models and conditions, ibuprofen at OTC doses (<1,200 mg/day) is generally of comparable efficacy to other NSAIDs and the same or slightly more effective than paracetamol OTC.

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    K. D. Rainsford

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Rainsford, K.D. (2012). Clinical Efficacy. In: Ibuprofen: Pharmacology, Therapeutics and Side Effects. Springer, Basel. https://doi.org/10.1007/978-3-0348-0496-7_4

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