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Viral Hemorrhagic Fevers

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Viral Infections of the Human Nervous System

Part of the book series: Birkhäuser Advances in Infectious Diseases ((BAID))

Abstract

Viral hemorrhagic fever (VHF) agents are dominantly from four major RNA virus families: the Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. General and hemorrhagic signs and symptoms of these viral infections are well known, but their neurological complications and clinical variants with distinct neurologic syndromes are not so famous. Pathologic features of VHF disease: systemic rapid viral replication, abnormal immune and inflammatory responses culminating in hemorrhage, edema, coagulopathies, multiorgan failure, and molecular properties, such as those shared with encephalitic members of the same family, are now, being recognized to contribute to a wide spectrum of neurologic disorders. Efforts to characterize and understand the pathogenesis of these VHF-associated central nervous system disorders are underway.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University, School of Medicine, Atlanta, GA, USA

    Guey Chuen Perng

  2. Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan

    Guey Chuen Perng

  3. Department of Internal Medicine (Neurology), University of Manitoba, Winnipeg, MB, Canada

    Marylou V. Solbrig

  4. Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada

    Marylou V. Solbrig

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  1. Guey Chuen Perng
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  2. Marylou V. Solbrig
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Correspondence to Marylou V. Solbrig .

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  1. , Health Sciences Centre, University of Manitoba, Sherbrook Street 820, Winnipeg, R3A 1R9, Manitoba, Canada

    Alan C. Jackson

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Perng, G.C., Solbrig, M.V. (2013). Viral Hemorrhagic Fevers. In: Jackson, A. (eds) Viral Infections of the Human Nervous System. Birkhäuser Advances in Infectious Diseases. Springer, Basel. https://doi.org/10.1007/978-3-0348-0425-7_14

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