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Proteases from Inflammatory Cells: Regulation of Inflammatory Response

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Proteases and Their Receptors in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

In this review, we summarize the current data pertaining to proteases mainly from polymorphonuclear neutrophil (PMN) and monocytes in the regulation of the inflammatory response. However, tryptase and chymase stored in mast cell granules, or granzymes from lymphocytes are other examples of proteases, which greatly influence several biological processes including extracellular matrix degradation, vasoconstriction, pathogen clearance, and cell death. A specific emphasis will be given to proteases from PMN, which are the first cells to be recruited to the inflammatory site. Proteases clearly modulate inflammation through cleavage of adhesion molecules, receptor implicated in pathogen recognition, phagocytosis, and production of cytokines. These cleavages can have pro or anti-inflammatory effect. In addition PMN-derived proteases can modulate the apoptosis of PMN and their uptake by macrophage, two pivotal steps in the resolution of inflammation. Deciphering the molecular mechanism governing the protease-based immune regulation should lead to novel and timely therapeutic strategies.

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Abbreviations

ANCA:

Antineutrophil cytoplasmic antibody

ADAM:

A disintegrin and a metalloprotease

BAI1:

Brain-specific angiogenesis inhibitor 1

CCL:

CC chemokine ligand

CCR:

CC chemokine receptor

CR:

Complement receptor

CRP:

C reactive protein

ECM:

Extracellular matrix

EGFR:

Epithelial growth factor receptor

FcγR:

Fcγ receptor

G-CSF:

Granulocyte colony-stimulating factor

G-CSFR:

G-CSF receptor

GM-CSF:

Granulocyte macrophage colony stimulating factor

ICAM:

Intercellular adhesion molecule

LFA-1:

Lymphocyte function-associated antigen 1

LPC:

Lysophosphatidylcholine

LPS:

Lipopolysaccharide

IL:

Interleukin

MAC1:

Macrophage receptor 1

MADCAM1:

Mucosal vascular addressin cell-adhesion molecule 1

MCP-1:

Monocyte chemotactic protein-1

MFG-E8:

Milk fat globule-EGF factor 8 protein

MIP:

Macrophage inflammatory protein

MMP:

Matrix metalloproteinase

MT1-MMP:

Membrane type-1 MMP

NADPH:

Nicotinamide adenine dinucleotide phosphate

NET:

Neutrophils extracellular trap

PAF:

Platelet-activating factor

PAR:

Protease-activated receptor

PGE2:

Prostaglandin E2

PLA2:

Phospholipase A2

PMN:

Polymorphonuclear neutrophils

PS:

Phosphatidylserine

PSGL1:

P-selectin glycoprotein ligand 1

PSR:

PS receptor

RANTES:

Regulated on activation normal T expressed and secreted

ROS:

Reactive oxygen species

SAA:

Serum amyloid A

SDF-1:

Stromal cell-derived factor-1

SHP2:

Src homology region 2 domain-containing phosphatase-1

SR-A:

Scavenger A

TIM-4:

T cell immunoglobulin mucin-4

TNFα:

Tumor necrosis factor

TNFR:

TNFα receptor

VCAM:

Vascular cell-adhesion molecule 1

VLA4:

Very late activation antigen-4

XIAP:

X-linked Inhibitor of apoptosis protein

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  1. Immunology-Hematology Department, INSERM U1016, Institut Cochin, Université Paris Descartes Paris, 27, rue du faubourg Saint Jacques, 75014, Paris, France

    Magali Pederzoli-Ribeil, Julie Gabillet & Véronique Witko-Sarsat

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  1. Magali Pederzoli-Ribeil
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  3. Véronique Witko-Sarsat
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  1. CHU Purpan, INSERM U 563, BP 3028, Toulouse Cedex, 31024, France

    Nathalie Vergnolle

  2. Institut Pasteur, Unite de Defense Innee et Inflammation, INSERM U 874, Rue du Dr. Roux 25, Paris Cedex 15, 75724, France

    Michel Chignard

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Pederzoli-Ribeil, M., Gabillet, J., Witko-Sarsat, V. (2011). Proteases from Inflammatory Cells: Regulation of Inflammatory Response. In: Vergnolle, N., Chignard, M. (eds) Proteases and Their Receptors in Inflammation. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0157-7_4

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