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Proteases and Their Receptors in Inflammation pp 253–274Cite as

Proteases and Inflammatory Pain

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Inflammation mediators are known to signal neurons and provoke pain. In this context, proteases can signal sensory neurons at the site of inflammation and modulate pain transmission. In this chapter, we will perform an overview of the multiple mechanisms whereby proteases can signal nerve endings. Proteases can directly activate proteases activated receptor at the membrane of the nerve endings to modulate pain signaling. They can not only be implicated in the secretion of molecules implicated in pain modulation by the nerve endings such as substance P or CGRP but also by other cell type such as fibroblast able to secrete opioid under protease stimulation. Proteases act on pain signal by cleaving proteins implicated in pain sensation, e.g., kalikreins can convert kininogen in bradykinin which acts on pain modulation. Proteins of nerve can be cleaved by proteases and provoke an increase in pain sensation following inflammation. These different mechanisms are explained in this chapter in the context of inflammatory pain.

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Abbreviations

APN:

AminoPeptidase N

ASIC:

Acid-sensing ion channels

B1R B2R:

Bradykinin receptor 1, 2

BK:

BradyKinin

CCI:

Chronic constriction injury

CD13:

Cluster of differentiation

CGRP:

Calcitonin gene-related peptide

CNS:

Central nervous system

COX:

CycloOXygenase

DAG:

DiAcylGlycerol

DRG:

Dorsal root ganglia

GABA:

Gamma-aminobutyric acid

GCP:

Glutamate carboxypeptidase

HEK:

Human embryonic kidney

IBS:

Irritable Bowel syndrome

IL:

InterLeukin

KLP:

Kallidin-like peptide

LPA:

LysoPhosphAtidic acid

MAG:

Myelin-associated glycoprotein

mGlu:

Metabotropic glutamate

MPO:

MyeloPerOxidase

NAAG:

N-AcetylAspartylGlutamate

NFL:

Neurofilament light chain

NK:

NeuroKinin

NMDA:

N-Methyl-d-aspartic acid

PAR:

Protease-activated receptor

PIP2:

Phosphatidyl Inositol 4,5-bisPhosphate

PKC:

Protein kinase C

PLC:

PhosphoLipase C

PMPA:

Phosphonomethyl pentanedioic acid

SP:

Substance P

TNF:

Tumor necrosis factor

TRP:

Transient receptor potential

TRPA:

Transient receptor potential ankyrin

TRPV:

Transient receptor potential vanilloid

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Authors and Affiliations

  1. INSERM, U1043, 31024, Toulouse, France

    Nicolas Cenac

  2. CNRS, U5282, 31024, Toulouse, France

    Nicolas Cenac

  3. Université de Toulouse, UPS, 31300, Toulouse, France

    Nicolas Cenac

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  1. Nicolas Cenac
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Correspondence to Nicolas Cenac .

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  1. CHU Purpan, INSERM U 563, BP 3028, Toulouse Cedex, 31024, France

    Nathalie Vergnolle

  2. Institut Pasteur, Unite de Defense Innee et Inflammation, INSERM U 874, Rue du Dr. Roux 25, Paris Cedex 15, 75724, France

    Michel Chignard

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Cenac, N. (2011). Proteases and Inflammatory Pain. In: Vergnolle, N., Chignard, M. (eds) Proteases and Their Receptors in Inflammation. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0157-7_11

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