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Molecular Definition of Inflammasomes

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The Inflammasomes

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Inflammasomes are crucial actors of the innate immunity. They consist of cytoplasmic multiprotein complexes controlling the biological activities of the inflammatory cytokines IL-1β and IL-18. Inflammasome assembly depends on protein domain interactions. In this chapter, we focus on the biochemical aspects characterizing the components of the inflammasomes and their assembly into a high molecular weight proteolytic complex.

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Authors and Affiliations

  1. Université de Lyon, Université Lyon 1, F-69000, Lyon, France

    Virginie Pétrilli

  2. Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000, Lyon, France

    Virginie Pétrilli

  3. CNRS5286, Centre de Recherche en Cancérologie de Lyon, F-69000, Lyon, France

    Virginie Pétrilli

  4. Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066, Epalinges, Switzerland

    Fabio Martinon

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  1. Virginie Pétrilli
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  2. Fabio Martinon
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Correspondence to Virginie Pétrilli .

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Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orléans CX 2, 45071, France

    Isabelle Couillin

  2. CNRS UMR 5201, Labo. Génétique et Cancer, Université de Lyon I, rue Laënnec 28, Lyon, 69008, France

    Virginie Pétrilli

  3. Dept. Immunology & Infectious, Diseases, Harvard School of Public Health, Huntington Ave. 651, Boston, 02115-6017, Massachusetts, USA

    Fabio Martinon

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Pétrilli, V., Martinon, F. (2011). Molecular Definition of Inflammasomes. In: Couillin, I., Pétrilli, V., Martinon, F. (eds) The Inflammasomes. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0148-5_1

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  • DOI: https://doi.org/10.1007/978-3-0348-0148-5_1

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