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Galanin pp 113–131Cite as

Neurochemical Modulation of Central Cardiovascular Control: The Integrative Role of Galanin

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Part of the book series: Experientia Supplementum ((EXS,volume 102))

Abstract

Galanin (GAL) is a peptide involved in multiple functions, including central cardiovascular control. In this review, the role of GAL and its fragments in the modulation of cardiovascular neuronal networks in the nucleus of the solitary tract is presented, including its interaction with the classical neurotransmitters and other neuropeptides involved in cardiovascular responses in this nucleus. First, we describe the cardiovascular responses of GAL and the pathway involved in these responses. Then we summarize findings obtained in our laboratory on how GAL, through its receptors, interacts with two other neuropeptides – Neuropeptide Y and Angiotensin II and their receptors – as they have particularly conspicuous cardiovascular effects. All these results strengthen the role of GAL in central cardiovascular control and indicate the existence of interactions among GAL receptor subtypes and α2-adrenergic receptors, AT1, and Y1 receptor subtypes. These interactions are crucial for understanding the integrative mechanisms responsible for the organization of the cardiovascular responses from the NTS.

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Acknowledgments

This study was supported by Spanish DGCYT BFI2008-3369 and SEJ01323.

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Authors and Affiliations

  1. Department of Physiology, University of Málaga, Málaga, Spain

    Zaida Díaz-Cabiale, Manuel Narváez, Carmelo Millón & José Angel Narváez

  2. Department of Histology, University of Málaga, Málaga, Spain

    Concepción Parrado

  3. Department of Psychobiology, University of Málaga, Málaga, Spain

    Araceli Puigcerver

  4. Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

    Kjell Fuxe

Authors
  1. Zaida Díaz-Cabiale
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  2. Concepción Parrado
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  3. Manuel Narváez
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  4. Carmelo Millón
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  5. Araceli Puigcerver
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  6. Kjell Fuxe
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  7. José Angel Narváez
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Correspondence to José Angel Narváez .

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Editors and Affiliations

  1. Dept. Neuroscience, Karolinska Institute, Retzius vaeg 8, Stockholm, 171 77, Sweden

    Tomas Hökfelt

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Díaz-Cabiale, Z. et al. (2010). Neurochemical Modulation of Central Cardiovascular Control: The Integrative Role of Galanin. In: Hökfelt, T. (eds) Galanin. Experientia Supplementum, vol 102. Springer, Basel. https://doi.org/10.1007/978-3-0346-0228-0_9

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