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Regional predisposition to atherosclerosis – An interplay between local hemodynamics, endothelial cells and resident intimal dendritic cells

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Endothelial Dysfunction and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Atherosclerosis develops in regions of the arterial tree with disturbed hemodynamics, but the underlying mechanisms of regional susceptibility to atherosclerosis are not fully understood. In this review, we summarize studies on intimal gene expression and cellular composition in atherosclerosis-susceptible regions of the normal mouse aorta, and discuss the implications to atherogenesis. Low-grade inflammation and accumulation of bone marrow-derived subendothelial resident intimal dendritic cells (RIDC) are unique features of atherosclerosis-susceptible regions. Upon induction of hypercholesterolemia, the RIDC rapidly accumulate intracellular lipid and become the initial foam cells of nascent atherosclerotic lesions, a step that precedes accelerated monocyte recruitment. Thus, unique regional intimal microenvironments established in the normal aorta play key roles in atherogenesis.

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Authors and Affiliations

  1. Toronto General Research Institute, Cell and Molecular Biology Division, University Health Network, Toronto, Ontario, M5G 2C4, Canada

    Jenny Jongstra-Bilen & Myron I. Cybulsky

  2. Department of Immunology, University of Toronto, Toronto, Canada

    Jenny Jongstra-Bilen

  3. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

    Jenny Jongstra-Bilen & Myron I. Cybulsky

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  1. Jenny Jongstra-Bilen
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Editors and Affiliations

  1. BC Cancer Research Center, West 10th Avenue 675, Vancouver, V5Z 1L3, British Columbia, Canada

    Shauna Dauphinee

  2. BC Cancer Research Centre, West 10th Avenue 675, Vancouver, V5Z 1L3, British Columbia, Canada

    Aly Karsan

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Jongstra-Bilen, J., Cybulsky, M.I. (2010). Regional predisposition to atherosclerosis – An interplay between local hemodynamics, endothelial cells and resident intimal dendritic cells. In: Dauphinee, S., Karsan, A. (eds) Endothelial Dysfunction and Inflammation. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0346-0168-9_10

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  • DOI: https://doi.org/10.1007/978-3-0346-0168-9_10

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