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Gene therapy for diabetes

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Gene Therapy for Autoimmune and Inflammatory Diseases

Part of the book series: Milestones in Drug Therapy ((MDT))

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Abstract

Diabetes mellitus is a devastating disease and the World Health Organization expects that the number of diabetic patients will increase to 300 million by the year 2025. Intensive glycemic control with insulin therapy to both Type 1 and Type 2 diabetic patients can reduce the risk of diabetic complications, but also increase the incidence of hypoglycemia. Many studies have shown the possibility of gene therapy for treatment of diabetes. Gene therapy can be successfully applied to treat Type 1 diabetes (T1D) and to facilitate the replacement of insulin-producing cells by islet transplantation, by differentiation of stem/progenitor cells, or by reversible immortalization in rodent models. Here we review potential approaches for the development of gene therapies for diabetes.

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Authors and Affiliations

  1. Regenerative Research Islet Cell Transplant Program, Baylor All Saints Medical Center, Baylor Research Institute, 1400 8th Avenue, Fort Worth, TX, 76104, USA

    Hirofumi Noguchi

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  1. Hirofumi Noguchi
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Editors and Affiliations

  1. Bone and Joint Research Unit Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK

    Yuti Chernajovsky

  2. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Paul D. Robbins

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Noguchi, H. (2010). Gene therapy for diabetes. In: Chernajovsky, Y., Robbins, P.D. (eds) Gene Therapy for Autoimmune and Inflammatory Diseases. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-0346-0165-8_3

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