Abstract
T CELL-MEDIATED IMMUNITY is an adaptive process of developing antigen (Ag)-specific T LYMPHOCYTES to eliminate viral, bacterial, or parasitic infections or malignant cells. T CELL-MEDIATED IMMUNITY can also involve aberrant recognition of self-Ag, leading to autoimmune inflammatory diseases. The Ag SPECIFICITY of T LYMPHOCYTES is based on recognition through the T CELL RECEPTOR (TCR) of unique antigenic peptides presented by MHC molecules on Ag-presenting cells (APC). T CELL-MEDIATED IMMUNITY is the central element of the adaptive immune system and includes a primary response by naive T cells, effector functions by activated T cells, and persistence of Ag-specific memory T cells. T CELL-MEDIATED IMMUNITY is part of a complex and coordinated immune response that includes other EFFECTOR CELLS such as MACROPHAGES, NATURAL KILLER CELLS, MAST CELLS, BASOPHILS, EOSINOPHILS, and NEUTROPHILS.
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© 2011 Birkhäuser Basel
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Broere, F., Apasov, S.G., Sitkovsky, M.V., van Eden, W. (2011). A2 T cell subsets and T cell-mediated immunity. In: Nijkamp, F., Parnham, M. (eds) Principles of Immunopharmacology. Birkhäuser Basel. https://doi.org/10.1007/978-3-0346-0136-8_2
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DOI: https://doi.org/10.1007/978-3-0346-0136-8_2
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