Abstract
Laser photothermal therapy utilizes gold nanorods/nanoshells embedded in tumors to enhance laser energy absorption in tumors via minimizing laser absorption in superficial tissue regions. The objective of this study is to develop a theoretical model to determine temperature elevations in a 10 mm diameter spherical tumor embedded inside a human breast model and to design a treatment protocol using laser photothermal therapy. Using the Pennes bioheat equation, we simulate temperature fields inside the tumor and its surrounding tissue before and during laser heating. Theoretical simulations show that using a laser intensity of 24000 W/m2 at the skin surface with a laser spot of 10 mm in diameter, the maximal and minimal temperatures in the tumor are 65 ℃ and 47 ℃, respectively. Equivalent minutes at 43 ℃ (EM43) are used to assess accumulated thermal damage within the tissue during the heating. Results illustrate that the heating time for causing irreversible thermal damage to the entire tumor is 916 s using the selected laser intensity and spot size. Although cold-water droplets are sprayed at the skin surface to protect skin and its surrounding healthy tissue, it is found that collateral thermal damage to the healthy tissue near the tumor (up to 2 mm) is inevitable. We conclude that theoretical simulation is a useful tool to evaluate temperature field during laser photothermal therapy and to design effective and safe heating protocols in clinical applications.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hirsch, L.R., et al.: Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc. Natl. Acad. Sci. U.S.A. 100(23), 13549–13554 (2003)
El-Sayed, I.H., Huang, X., El-Sayed, M.A.: Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles. Cancer Lett. 239(1), 129–135 (2006)
Jain, P.K., Lee, K.S., El-Sayed, I.H., El-Sayed, M.A.: Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J. Phys. Chem. B 110(14), 7238–7248 (2006)
Skrabalak, S.E., Chen, J., Au, L., Lu, X., Li, X., Xia, Y.: Gold nanocages for biomedical applications. Adv. Mater. 19, 3177–3184 (2007)
Khlebtsov, B., Zharov, V., Melnikov, A., Tuchin, V., Khlebtsov, N.: Optical amplification of photothermal therapy with gold nanoparticles and nanoclusters. Nanotechnology 17, 5167–5179 (2006)
Manuchehrabadi, N., et al.: MicroCT imaging and in vivo temperature elevations in implanted prostatic tumors in laser photothermal therapy using gold nanorods. ASME J. Nanotechnol. Eng. Med. 3, 021003(1–7) (2012)
Manuchehrabadi, N., et al.: Tumor shrinkage studies and histological analyses after laser photothermal therapy using gold nanorods. J. Biomed. Eng. Technol. 12, 157–175 (2013)
Pennes, H.H.: Analysis of tissue and arterial blood temperature in the resting human forearm. J. Appl. Phys. 1, 93–122 (1948)
Manuchehrabadi, N., Chen, Y., Lebrun, A., Ma, R., Zhu, L.: Computational simulation of temperature elevations in tumors using Monte Carlo method and comparison to experimental measurements in laser photothermal therapy. J. Biomech. Eng. 135, 121007(1–11) (2013)
Manuchehrabadi, N., Zhu, L.: Development of a computational simulation tool to design a protocol for treating prostate tumours using transurethral laser photothermal therapy. Int. J. Hyperth. 30(6), 349–361 (2014)
Mourant, J.R., Fuselier, T., Boyer, J., Johnson, T.M., Bigio, I.J.: Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms. Appl. Opt. 36(4), 949–957 (1997)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Quinn, E., Singh, M., Zhu, L. (2024). Simulation-Based Treatment Protocol Design for Damaging Breast Tumor Using Laser Photothermal Therapy. In: Skalli, W., Laporte, S., Benoit, A. (eds) Computer Methods in Biomechanics and Biomedical Engineering II. CMBBE 2023. Lecture Notes in Computational Vision and Biomechanics, vol 39. Springer, Cham. https://doi.org/10.1007/978-3-031-55315-8_11
Download citation
DOI: https://doi.org/10.1007/978-3-031-55315-8_11
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-55314-1
Online ISBN: 978-3-031-55315-8
eBook Packages: EngineeringEngineering (R0)