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Patient Stratification Based on Fast Simulation of Cardiac Electrophysiology on Digital Twins

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Statistical Atlases and Computational Models of the Heart. Regular and CMRxRecon Challenge Papers (STACOM 2023)

Abstract

After a myocardial infarction, electrophysiologists must assess the risk of the patient to develop a lethal arrhythmia. A cardiac magnetic resonance can help to evaluate the infarcted region, and provide insights into the electrically remodeled regions. However, it is not possible to evaluate the heart function or predict the behavior of slow conduction channels without an electrophysiology study. In this paper, we present a fully automatic screening approach based on fast simulation of cardiac electrophysiology, to determine arrhythmogeneity of myocardial infarction on patients. We show the accuracy and potential of the computer based approach, by comparing CathLab and simulation protocols to induce VT in 16 patients, obtaining a match between them.

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References

  1. Arevalo, H.J., et al.: Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models. Nat. Commun. 7, 11437 (2016). https://doi.org/10.1038/ncomms11437

  2. Aronis, K.N., et al.: Characterization of the electrophysiologic remodeling of patients with ischemic cardiomyopathy by clinical measurements and computer simulations coupled with machine learning. Front. Physiol. 12, 684149 (2021). https://doi.org/10.3389/fphys.2021.684149

    Article  Google Scholar 

  3. Barber, F., et al.: Estimation of personalized minimal Purkinje systems from human electro-anatomical maps. IEEE Trans. Med. Imaging 40(8), 2182–2194 (2021)

    Article  Google Scholar 

  4. Cronin, E.M., et al.: 2019 hrs/ehra/aphrs/lahrs expert consensus statement on catheter ablation of ventricular arrhythmias: executive summary. J. Arrhythm. 36(1), 1–58 (2020). https://doi.org/10.1002/joa3.12264

    Article  Google Scholar 

  5. Deng, D., Prakosa, A., Shade, J., Nikolov, P., Trayanova, N.A.: Characterizing conduction channels in postinfarction patients using a personalized virtual heart. Biophys. J . 117(12), 2287–2294 (2019). https://doi.org/10.1016/j.bpj.2019.07.024

    Article  Google Scholar 

  6. Doste, R., et al.: A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts. Int. J. Numer. Method Biomed. Eng. 35(4), e3185 (2019). https://doi.org/10.1002/cnm.3185

    Article  Google Scholar 

  7. Godoy, E.J., et al.: Atrial fibrosis hampers non-invasive localization of atrial ectopic foci from multi-electrode signals: a 3D simulation study. Front. Physiol. 9, 404 (2018). https://doi.org/10.3389/fphys.2018.00404

    Article  Google Scholar 

  8. Lopez-Perez, A., Sebastian, R., Izquierdo, M., Ruiz, R., Bishop, M., Ferrero, J.M.: Personalized cardiac computational models: from clinical data to simulation of infarct-related ventricular tachycardia. Front. Physiol. 10, 580 (2019). https://doi.org/10.3389/fphys.2019.00580

    Article  Google Scholar 

  9. Maleckar, M.M., et al.: Combined in-silico and machine learning approaches toward predicting arrhythmic risk in post-infarction patients. Front. Physiol. 12, 745349 (2021). https://doi.org/10.3389/fphys.2021.745349

    Article  Google Scholar 

  10. Serra, D., et al.: An automata-based cardiac electrophysiology simulator to assess arrhythmia inducibility. Mathematics 10(8), 1293 (2022)

    Article  Google Scholar 

  11. Soto-Iglesias, D., et al.: Cardiac magnetic resonance-guided ventricular tachycardia substrate ablation. JACC Clin. Electrophysiol. 6(4), 436–447 (2020). https://doi.org/10.1016/j.jacep.2019.11.004

  12. Sung, E., Etoz, S., Zhang, Y., Trayanova, N.A.: Whole-heart ventricular arrhythmia modeling moving forward: mechanistic insights and translational applications. Biophys. Rev. (Melville) 2(3) (2021). https://doi.org/10.1063/5.0058050

  13. Trayanova, N.A., Doshi, A.N., Prakosa, A.: How personalized heart modeling can help treatment of lethal arrhythmias: a focus on ventricular tachycardia ablation strategies in post-infarction patients. Wiley Interdiscip. Rev. Syst. Biol. Med. 12(3), e1477 (2020). https://doi.org/10.1002/wsbm.1477

    Article  Google Scholar 

  14. Zhou, S., et al.: Feasibility study shows concordance between image-based virtual-heart ablation targets and predicted ECG-based arrhythmia exit-sites. Pacing Clin. Electrophysiol. 44(3), 432–441 (2021). https://doi.org/10.1111/pace.14181

    Article  Google Scholar 

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Correspondence to Rafael Sebastian .

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Serra, D. et al. (2024). Patient Stratification Based on Fast Simulation of Cardiac Electrophysiology on Digital Twins. In: Camara, O., et al. Statistical Atlases and Computational Models of the Heart. Regular and CMRxRecon Challenge Papers. STACOM 2023. Lecture Notes in Computer Science, vol 14507. Springer, Cham. https://doi.org/10.1007/978-3-031-52448-6_4

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  • DOI: https://doi.org/10.1007/978-3-031-52448-6_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-52447-9

  • Online ISBN: 978-3-031-52448-6

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