Skip to main content

Towards Industry 4.0: An IoT-Enabled Data-Driven Architecture for Predictive Maintenance in Pharmaceutical Manufacturing

  • Conference paper
  • First Online:
International Conference on Advanced Intelligent Systems for Sustainable Development (AI2SD’2023) (AI2SD 2023)

Abstract

In recent years, there has been a surge in the adoption of Predictive Maintenance (PdM) systems. This is primarily due to their ability to restrict maintenance expenses, reduce unscheduled downtime, and enhance the dependability of equipment. The implementation of Predictive Maintenance (PdM) systems holds significant importance in the pharmaceutical industry, where equipment downtime can have severe implications for product quality and patient safety. The present study puts forth a system architecture for PdM in the pharmaceutical sector, with a particular emphasis on the cyclotron as a case study. Several novel characteristics distinguish our predictive maintenance architecture from prior techniques. We start with advanced machine learning techniques that can handle complex and dynamic cyclotron data patterns. Second, we combine realtime sensor data from many sources for precise health monitoring and fault diagnosis. Our design also uses a data-driven prognostic model to predict breakdowns and suggest maintenance. These innovative parts create a full, proactive cyclotron maintenance system. The implementation of a PdM system has the potential to enhance operational efficiency, ensure safety, and improve product quality by anticipating equipment malfunctions prior to their occurrence. The proposed architecture for predictive maintenance makes a significant contribution to the field of cyclotron maintenance. By leveraging advanced machine learning techniques, real-time sensor data integration, and proactive fault prediction, our solution addresses the critical challenges associated with ensuring cyclotrons operate without interruption. Our research opens up novel possibilities for optimizing predictive maintenance for complex, high-stakes systems such as cyclotrons.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Tannoury, M., Attieh, Z.: The influence of emerging markets on the pharmaceutical industry. Curr. Ther. Res. 86, 19–22 (2017)

    Article  Google Scholar 

  2. Witty, A.: New strategies for innovation in global health: a pharmaceutical industry perspective. Health Aff. 30(1), 118–126 (2011)

    Article  Google Scholar 

  3. Garrett, L.: The challenge of global health. Foreign Affairs, 14–38 (2007)

    Google Scholar 

  4. Temin, P.: Technology, regulation, and market structure in the modern pharmaceutical industry. Bell J. Econ. 429–446 (1979)

    Google Scholar 

  5. Modgil, S., Sharma, S.: Total productive maintenance, total quality management and operational performance: an empirical study of indian pharmaceutical industry. J. Qual. Maint. Eng. 22(4), 353–377 (2016)

    Article  Google Scholar 

  6. Jezzini, A., Ayache, M., Elkhansa, L., Makki, B., Zein, M.: Effects of predictive maintenance (pdm), proactive maintenace (pom) & preventive maintenance (pm) on minimizing the faults in medical instruments. In: 2013 2nd International Conference on Advances in Biomedical Engineering, pp. 53–56. IEEE (2013)

    Google Scholar 

  7. Wang, Y., Deng, C., Wu, J., Wang, Y., Xiong, Y.: A corrective maintenance scheme for engineering equipment. Eng. Fail. Anal. 36, 269–283 (2014)

    Article  Google Scholar 

  8. Basri, E.I., Razak, I.H.A., Ab-Samat, H., Kamaruddin, S.: Preventive maintenance (pm) planning: a review. J. Qual. Maint. Eng. 23(2), 114–143 (2017)

    Article  Google Scholar 

  9. Skilton, M., Hovsepian, F.: The 4th Industrial Revolution. Springer (2018)

    Google Scholar 

  10. Reinhardt, I.C., Oliveira, J.C., Ring, D.T.: Current perspectives on the development of industry 4.0 in the pharmaceutical sector. J. Indust. Inform. Integrat. 18, 100131 (2020)

    Google Scholar 

  11. Mobley, R.K.: An Introduction to Predictive Maintenance. Elsevier (2002)

    Google Scholar 

  12. Malerba, F., Orsenigo, L.: The evolution of the pharmaceutical industry. Bus. Hist. 57(5), 664–687 (2015)

    Article  Google Scholar 

  13. Schuchat, A.: Human vaccines and their importance to public health. Procedia Vaccinol. 5, 120–126 (2011)

    Article  Google Scholar 

  14. Comanor, W.S.: The political economy of the pharmaceutical industry. J. Econ. Literat. 24(3), 1178–1217 (1986)

    Google Scholar 

  15. Ostwald, D., Cramer, M., Albu, N., Tesch, J.: The global economic impact of the 18 pharmaceutical industry. Economic Footprint, 2021–2022 (2020)

    Google Scholar 

  16. Rodionova, O.Y., Sokovikov, Y.V., Pomerantsev, A.: Quality control of packed raw materials in pharmaceutical industry. analytica chimica acta 642(1–2), 222– 227 (2009)

    Google Scholar 

  17. Shaw, B., Whitney, P.: Ethics and compliance in global pharmaceutical industry marketing and promotion: the role of the ifpma and self-regulation. Pharmac. Policy Law 18(1–4), 199–206 (2016)

    Google Scholar 

  18. C¸ oban, S., G¨okalp, M.O., G¨okalp, E., Eren, P.E., Ko¸cyi˘git, A.: [wip] predictive maintenance in healthcare services with big data technologies. In: 2018 IEEE 11th Conference on Service-Oriented Computing and Applications (SOCA), pp. 93–98. IEEE (2018)

    Google Scholar 

  19. Hao, Q., Xue, Y., Shen, W., Jones, B., Zhu, J.: A decision support system for integrating corrective maintenance, preventive maintenance, and condition-based maintenance. In: Construction Research Congress 2010: Innovation for Reshaping Construction Practice, pp. 470–479 (2010)

    Google Scholar 

  20. Garmaroodi, M.S.S., Farivar, F., Haghighi, M.S., Shoorehdeli, M.A., Jolfaei, A.: Detection of anomalies in industrial iot systems by data mining: study of christ osmotron water purification system. IEEE Internet Things J. 8(13), 10280–10287 (2020)

    Article  Google Scholar 

  21. Calzavara, G., Oliosi, E., Ferrari, G.: A time-aware data clustering approach to predictive maintenance of a pharmaceutical industrial plant. In: 2021 International Conference on Artificial Intelligence in Information and Communication (ICAIIC), pp. 454–458. IEEE (2021)

    Google Scholar 

  22. Mannavarapu, K., Sivaji, V.K.: Implementation of iot-based predictive maintenance in pharmaceutical industry (2020)

    Google Scholar 

  23. Oliosi, E., Calzavara, G., Ferrari, G.: On sensor data clustering for machine status monitoring and its application to predictive maintenance. IEEE Sens. J. (2023)

    Google Scholar 

  24. Zurcher, P., Badr, S., Knuppel, S., Sugiyama, H.: Data-driven approach toward long-term equipment condition assessment in sterile drug product manufacturing. ACS Omega 7(41), 36415–36426 (2022)

    Article  Google Scholar 

  25. Stamatis, D.H.: Failure Mode and Effect Analysis: FMEA from Theory to Execution. Quality Press (2003)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Oumaima Manchadi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Manchadi, O., Ben-BOUAZZA, FE., Dehbi, Z.E.O., Said, Z., Jioudi, B. (2024). Towards Industry 4.0: An IoT-Enabled Data-Driven Architecture for Predictive Maintenance in Pharmaceutical Manufacturing. In: Ezziyyani, M., Kacprzyk, J., Balas, V.E. (eds) International Conference on Advanced Intelligent Systems for Sustainable Development (AI2SD’2023). AI2SD 2023. Lecture Notes in Networks and Systems, vol 905. Springer, Cham. https://doi.org/10.1007/978-3-031-52385-4_4

Download citation

Publish with us

Policies and ethics