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Application of Reference Materials in the Analysis of Medicinal Plant Raw Materials and Herbal Medicinal Products

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Reference Materials in Measurement and Technology (RMMT 2022)

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Abstract

In order to improve the standardization of medicinal plant raw materials and herbal medicinal products, new approaches to the analysis of plant objects are required. We substantiate the use of reference materials (RMs) in the development of assay procedures using a number of plant raw materials as an example. Biologically active compounds contained in these materials are studied in terms of their chemical composition, stability, and physicochemical properties. Active substances were determined by HPLC-UV. The results were processed using WinASPECT and Microsoft Excel 2016. Assay procedures were developed and validated for determining syringin in Syringa vulgaris bark and Eleutherococcus senticosus rhizomes and roots; rosavin and salidroside in Rhodiola rosea rhizomes and roots; arbutin in Arctostaphylos uva-ursi and Vaccinium vitis-idaea leaves; isosalipurposide in Helichrysum arenarium flowers; anthracene derivatives in Aloe arborescens leaves. Spectrophotometric methods for determining the amount of biologically active phenylpropanoids in terms of eleutheroside B (syringin) in medicinal plant raw materials and herbal medicinal products of Eleutherococcus senticosus and the amount of aralosides in Aralia mandschurica roots were proposed. The feasibility of using the RMs of syringin, rosavin and salidroside, araloside ammonium salts, arbutin, aloins A and B mixtures in assay procedures was substantiated.

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Notes

  1. 1.

    FS.3.4.0009.18 Eleutherococcus prickly rhizomes and roots liquid extract. Available via Pharmacopoeia RF. https://pharmacopoeia.ru/fs-2-5-0053-15-eleuterokokka-kolyuchego-kornevishha-i-korni/. Accessed 26 August 2022 (In Russ.).

  2. 2.

    FS.2.5.0007.1 Sand immortelle flowers. Available via Pharmacopoeia RF. https://pharmacopoeia.ru/fs-2-5-0007-15-bessmertnika-peschanogo-tsvetki/. Accessed 26 August 2022 (In Russ.).

  3. 3.

    OFS.1.2.1.2.0001.15 Chromatography. Available via Pharmacopoeia RF. https://pharmacopoeia.ru/ofs-1-2-1-2-0001-15-hromatografiya/. Accessed 26 August 2022 (In Russ.).

  4. 4.

    OFS.1.1.0013.15 Statistical processing of the results of chemical experiments. Available via Pharmacopoeia RF. https://pharmacopoeia.ru/wp-content/uploads/2016/11/OFS.1.1.0013.15-Statisticheskaya-obrabotka-rezultatov-eksperimenta.pdf. Accessed 26 August 2022 (In Russ.).

  5. 5.

    OFS.1.1.0012.15 Validation of analytical methods. Available via Pharmacopoeia RF. https://pharmacopoeia.ru/ofs-1-1-0012-15-validatsiya-analiticheskih-metodik/. Accessed 26 August 2022 (In Russ.).

Abbreviations

BACs:

Biologically active compounds

HPLC:

High performance liquid chromatography

MPRM:

Medicinal plant raw material

HMP:

Herbal medicinal product

RM:

Reference material

References

  1. Samylina IA, Kurkin VA, Yakovlev GP (2016) Scientific basis of the development and standardization of herbal medicines. Bull Sci Centre Expert Eval Med Prod Regul Res Med Eval 1:41–44 (in Russian)

    Google Scholar 

  2. Volkova RA, Fadeikina OV, Ustinnikova OB, Sakanyan EI, Merkulov VA, Movsesyants AA et al (2020) Current problems with the standard samples of medicines in the Russian Federation. Farmatsiya 69(2):5–11 (in Russian). https://doi.org/10.29296/25419218-2020-02-01

  3. Voronin AV, Malkova AV (2020) Methodology for the study of some multicomponent objects of analytical control in forensic chemical expertise and pharmaceutical analysis: monograph. Insoma-press, Samara, 328 p (in Russian)

    Google Scholar 

  4. Leontiev DA, Podpruzhnikov YV, Volovyk NV (2016) The role of reference standards in quality assurance for medicines: regulatory and metrological aspects. Drug Dev Registration 3:180–188 (in Russian)

    Google Scholar 

  5. Sakanyan EI, Kovaleva EL, Frolova LN, Shelestova VV (2018) Current requirements for the quality of herbal medicinal products. Bull Sci Centre Expert Eval Med Products 8(3):170–178 (in Russian). https://doi.org/10.30895/1991-2919-2018-8-3-170-178

  6. Sokol’skaya TA, Shemeryankina TB, Dargaeva TD (2011) Use of reference standards for the analysis of herbal medicines. Bull Sci Centre Expert Eval Med Prod 2:43–46 (in Russian)

    Google Scholar 

  7. Shemeryankina TB, Sakanyan EI, Merkulov VA, Bunyatyan ND, Kovalyova EL, Mit’kina LI et al (2014) The requirements for methods of analysis and the quality of pharmacopoeia reference standards for herbal medicines. Bull Sci Centre Expert Eval Med Prod 1:51–54 (in Russian)

    Google Scholar 

  8. Kurkin VA, Avdeeva EV, Kurkina AV, Pravdivtseva OE et al (2016) The actual aspects of the standardization of medicinal plant materials and phytopharmaceuticals. In: Modern problems of pharmacognosy. Collection of materials of the I Interuniversity student scientific and practical conference, dedicated to the 45th anniversary of the pharmaceutical faculty of the Samara State Medical University, 22 Oct 2016, Samara, Russia. SamSMU, Samara, pp 123–127 (in Russian)

    Google Scholar 

  9. Olennikov DN, Zilfikarov IN, Ibragimov TA (2010) Study of the chemical composition of Aloe Arborescens Mill. Khimiya Rastitel’nogo Syr’ya 3:77–82 (in Russian)

    Google Scholar 

  10. State Pharmacopoeia of the Russian Federation, XIV edn., 4 vols. Moscow (2018). Available via Ministry of Health of the Russian Federation. https://minzdrav.gov.ru/poleznye-resursy/xiv-izdanie-gosudarstvennoy-farmakopei-rossiyskoy-federatsii. Accessed 26 Aug 2022 (in Russian)

  11. European Pharmacopoeia, 10th edn. Available via Council of Europe. https://pheur.edqm.eu/home. Accessed 26 Aug 2022

  12. American Herbal Pharmacopoeia Botanical Pharmacognosy. CRC Press, Boca Raton, American Herbal Medicine Association, Florida, USA, 733 p (2011)

    Google Scholar 

  13. Moiseev DV (2011) Determination of arbutine in cowberry leaves by HPLC. Vestnik farmatsii 1(51):40–45 (in Russian)

    Google Scholar 

  14. Fedoseeva LM (2003) Analysis of arbutin in underground and aboveground vegetative organs of the thick-leaved bergenia (Bergenia crassifolia (L.) Fitsch.) Growing in Altai. Khimiya rastitel’nogo syr’ya 1:73–77 (in Russian)

    Google Scholar 

  15. Chemical information review document for arbutin [CAS No. 497-76-7] and extracts from Arctostaphylos uva-ursi. Available via Semantic Scholar. https://www.semanticscholar.org/paper/Chemical-Information-Review-Document-for-Arbutin/0d65672d2e6f910a0d9351786424f32cff65c089. Accessed 26 Aug 2022

  16. (2012) EMA/HMPC/573462/2009 Rev.1 committee on herbal medicinal products (HMPC) Arctostaphylos uva-ursi (L.) Spreng., folium

    Google Scholar 

  17. Kurkin VA, Ryazanova TK (2018) Quantitative determination of total saponins in Aralia mandshurica plant raw material. Pharm Chem J 52(5):455–458. https://doi.org/10.1007/s11094-018-1838-x

    Article  Google Scholar 

  18. Kurkin VA, Zapesochnaya GG, Kiryanov AA et al (1989) On the quality of raw materials of Rhodiola rosea. Pharm Chem J 11:1364–1367 (in Russian)

    Google Scholar 

  19. Kiryanov AA, Bondarenko LT, Kurkin VA et al (1989) Dynamics of accumulation of rosavidin and salidroside in the rhizomes of Rhodiola rosea. Pharmaceutical Chemistry Journaln 23(4):449–452 (in Russian)

    Google Scholar 

  20. Kurkin VA (2003) Phenylpropanoids of medicinal plants. Distribution, classification, structural analysis, biological activity. Chem Nat Compd 2:87–110 (in Russian)

    Google Scholar 

  21. Kurkina AV (2012) Flavonoids of pharmacopoeial plants: monograph Etching, Samara State Medical University of the Ministry of Health and Social Development of Russia, Samara, 290 p (in Russian)

    Google Scholar 

  22. Kurkina AV (2011) Actual aspects of standardization of medicinal plant materials containing flavonoids. Bull Siberian Med 5:150–153 (in Russian). https://doi.org/10.20538/1682-0363-2011-5-150-154

  23. Kurkina AV, Ryzhov VM (2011) Assay of isosalipurposide in raw material and drugs from the dwarf everlast (Helichrysum arenarium). Farmatsiya 1:12–14 (in Russian)

    Google Scholar 

  24. The United States Pharmacopeia and The National Formulary (USP 38-NF 33), The United States Pharmacopeial Convention. Inc.: Rockville, MD (2015)

    Google Scholar 

  25. Japanese Pharmacopoeia, 18th edn. The Ministry of Health, Labour and Welfare (2021)

    Google Scholar 

  26. Sergunova EV, Sorokina AA (2019) Study of the quality indicators of arborescent aloe (aloearborescens) leaves subjected to different preservation procedures. Farmatsiya 7(68):21–25 (in Russian). https://doi.org/10.29296/25419218-2019-07-04

  27. Olennikov D, Rokhin A, Zilfikarov I (2008) Method for determining content of phenolic compounds in Aloe arborescens. Chem Nat Compd 44:715–718

    Article  Google Scholar 

  28. Zilfikarov IN, Olennikov D, Ibragimov TA, Chelombit’ko VA, Vandyshev VV (2013) Modern aspects of pharmacognostic and biochemical study of succulent raw material of Aloe arborescens and Callisia fragrans. Publisher Marchotin P. Yu., Moscow Region, Schyolkovo

    Google Scholar 

  29. Kurkin VA, Ryazanova TK, Platonov IA, Pavlova LV (2015) Quantitative determination of arbutin in the leaves of Arctostaphylos uva-ursi (L.) Spreng. Khimija Rastitel’nogo Syr’ja 1:95–100 (in Russian)

    Google Scholar 

  30. Kurkin VA, Ryazanova TK, Platonov IA, Pavlova LV (2017) Determination of arbutin in Vaccinium vitis-idaea L. leaves. Pharmaceut Chem J 51(4):34–37 (in Russian)

    Google Scholar 

  31. Kurkin VA, Ryazanova TK, Serebryakova AD (2021) Development of approaches to standardization of bark of Syringa vulgaris L. Probl Biol Med Pharmaceut Chem 24(7):37–44 (in Russian). https://doi.org/10.29296/25877313-2021-07-06

  32. Kurkin VA, Ryazanova TK, Shmygareva AA, Glushchenko SN (2021) HPLC determination of aloenin in leaves and preparations of Aloe arborescens Mill. Pharmaceut Chem J 55(5):13–18 (in Russian). https://doi.org/10.30906/0023-1134-2021-55-5-13-18

  33. Kurkin VA, Ryazanova TK (2021) Current aspects of standardization of Rhodiola rosea L. rhizomes and roots. Pharmaceut Chem J 55(8):40–44 (in Russian). https://doi.org/10.30906/0023-1134-2021-55-8-40-44

  34. Kurkin VA, Ryazanova TK, Shmygareva AA, Glushchenko SN (2021) The development of methods for determination the total of anthracene derivatives in raw materials and preparations of Aloe arborescens Mill. Khimiya rastitel'nogo syr'ya 3:153–161 (in Russian). https://doi.org/10.14258/jcprm.2021039221

  35. Kurkin VA, Ryazanova TK (2021) Standardization problems of medicinal preparations from Rhodiola rosea L. Pharmacy Pharmacol 9(3):185–194 (in Russian). https://doi.org/10.19163/2307-9266-2021-9-3-185-194

  36. Kurkin VA, Ryazanova TK (2022) Methodological approaches to standardization of rhizomes and roots of Eleutherococcus senticosus. Pharmaceut Chem J 56(3):34–41 (in Russian). https://doi.org/10.30906/0023-1134-2022-56-3-34-41

  37. Ryazanova TK, Kurkina AV, Kurkin VA (2022) Development of approaches to standardization of raw materials and preparations of Helichrysum arenarium. In: From plant biochemistry to human biochemistry. International scientific conference. Moscow, pp 237–241

    Google Scholar 

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Acknowledgements

The study was carried out within the project “Development of national approaches to the standardization of herbal medicinal products, medicinal plant raw materials and phytobiotechnological products” under the financial government support in the form of a Scholarship of the President of the Russian Federation for young scientists and postgraduates carrying out promising research and development on priority directions of Russian economy modernization. The authors are grateful to the reviewers for their valuable recommendations and constructive attitude.

Contribution of the Authors

Ryazanova T.K.—conducting research, development of a methodology, formal analysis, validation, writing a draft of the article; Kurkin V. A.—development of the research concept, interpretation of 1H-NMR, 13C-NMR spectra, mass spectra and UV spectra of isolated BACs, revision of the text.

Conflict of Interest

The article was prepared on the basis of a report presented at the V International Scientific Conference “Reference Materials in Measurement and Technology” (Yekaterinburg, September 13–16, 2022). The article was admitted for publication after the abstract was revised, the article was formalized, and the review procedure was carried out.

The version in the Russian language is published in the journal “Measurement Standards. Reference Materials” 2023;19(2):47–60. (In Russ.). https://doi.org/10.20915/2077.1177.2023.19.2-47-60.

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Authors and Affiliations

  1. Samara State Medical University of the Ministry of Health of the Russian Federation, Samara, Russia

    Tatyana K. Ryazanova & Vladimir A. Kurkin

Authors
  1. Tatyana K. Ryazanova
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  2. Vladimir A. Kurkin
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Correspondence to Tatyana K. Ryazanova .

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Editors and Affiliations

  1. UNIIM—Affiliated Branch of the D. I. Mendeleyev Institute for Metrology, Yekaterinburg, Russia

    Egor P. Sobina

  2. UNIIM—Affiliated Branch of the D. I. Mendeleyev Institute for Metrology, Yekaterinburg, Russia

    Sergey V. Medvedevskikh

  3. UNIIM—Affiliated Branch of the D. I. Mendeleyev Institute for Metrology, Yekaterinburg, Russia

    Olga N. Kremleva

  4. All-Russian Scientific Research Institute for Optical and Physical Measurements, Moscow, Russia

    Ivan S. Filimonov

  5. All-Russian Scientific Research Institute for Metrological Service, Moscow, Russia

    Elena V. Kulyabina

  6. D. I. Mendeleyev Institute for Metrology, Saint Petersburg, Russia

    Anna V. Kolobova

  7. Saint Petersburg State University, PetroAnalytica LLC, Saint Petersburg, Russia

    Andrey V. Bulatov

  8. All-Russian Scientific Research Institute of Physicotechnical and Radio Engineering Measurements, Moscow, Russia

    Vladimir I. Dobrovolskiy

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Ryazanova, T.K., Kurkin, V.A. (2024). Application of Reference Materials in the Analysis of Medicinal Plant Raw Materials and Herbal Medicinal Products. In: Sobina, E.P., et al. Reference Materials in Measurement and Technology . RMMT 2022. Springer, Cham. https://doi.org/10.1007/978-3-031-49200-6_8

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